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Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent

  • Sutopo Hadi EMAIL logo , Hidayatul Mustafidah , Yandri Yandri , Wasinton Simanjuntak and Tati Suhartati
Published/Copyright: February 16, 2024
Pure and Applied Chemistry
From the journal Pure and Applied Chemistry Volume 96 Issue 3

Abstract

In this work, three organotin (IV) derivatives namely dibutyltin(IV) di-2-hydroxybenzoate (DBT2-HBz) (2), dibutyltin(IV) di-3-hydroxybenzoate (DBT3-HBz) (3) and dibutyltin(IV) di-4-hydroxybenzoate (DBT4-HBz)) (4) were synthesized and tested as disinfectant against pathogenic bacteria, Staphylococcus aureus. Compounds 2–4 were prepared by reacting dibutyltin(IV) oxide (DBTO) (1) with 2-hydroxybenzoic acid (2-HHBz), 3-hydroxybenzoic acid (3-HHBz) and 4-hydroxybenzoic acid (4-HHBz). The synthesized compounds were characterized by spectroscopic techniques including UV–Vis, FT-IR, 1H NMR, and 13C NMR, and micro-elemental analyzer. The optical density (OD) of compounds was measured by UV–Vis at 600 nm, which showed good bioactivity against the S. aureus. The data obtained indicated that compound 4 has higher bioactivity than compound 2 and 3, and the positive control using a commercial disinfectant containing 5 % benzalkonium chloride. The optimum bioactivity of compound 4 was observed at a concentration of 5 × 10−4 M with a contact time of 10 min, as shown by the decrease in absorbance from 0.6092 to 0.4005. Compound 2 was optimal at a concentration of 5 × 10−4 M with a contact time of 10 min, and the absorbance decreased from 0.6092 to 0.4416. Compound 3 and positive control showed a smaller decrease in absorbance compared to compound 4 and 2. Overall, the results obtained indicated that the compounds synthesized have promising potential as disinfectant against pathogenic bacteria.

Keywords: Dibutyltin(IV) dihydroxybenzoate; disinfectant agent; optical density; S. aureus ; VCCA-2023
Corresponding author: Sutopo Hadi, Department of Chemistry, Universitas Lampung, Bandar Lampung, 35415, Indonesia, e-mail:
Article note: A collection of invited papers based on presentations at the Virtual Conference on Chemistry and its Applications 2023 (VCCA-2023).

Funding source: Direktorat Jenderal Pendidikan Tinggi

Award Identifier / Grant number: 027/E5/PG.02.00.PL/2023

Acknowledgments

We would like to thank some people who have to help us in the experimental part, Liza Aprilia and Tri Kiswantari for their help and for allowing us to use some spaces in the laboratory. We are grateful to the Institute of Research and Community Services, Universitas Lampung for giving us support in obtaining the research funding.

  1. Research ethics: Not applicable.

  2. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: No conflict of interest.

  4. Research funding: The authors’ gratitude to the Institute of Research and Community Services, Universitas Lampung as well as Directorate of Research and Community Services, The Ministry of Education, Cultural. Research and Technology, Indonesia. that gave access to funding the assignment carried out through Penelitian Dasar (Basic Research Grant Scheme) 2023 with agreement numbers of 027/E5/PG.02.00.PL/2023 on 12th April 2023 and 2192/UN26.21/PN/2023 on 17th April 2023.

  5. Data availability: The data are available from the corresponding author upon request and are included in the manuscript.

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Published Online: 2024-02-16
Published in Print: 2024-03-25

© 2024 IUPAC & De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Preface
  4. The virtual conference on chemistry and its applications, VCCA-2023, 7–11 August 2023
  5. Special topic papers
  6. Recovery of wipe sampling of urban surfaces contaminated with blistering chemical warfare agents
  7. Bioremediation of cadmium contaminated soil by tea waste and impact on the accumulation of Cd in Helianthus annuus
  8. Exploring the potential of Meldrum’s acid-bearing chain extenders for mechanical recycling of PET
  9. In silico and in vitro profiling of coumarins and flavonoids for anti-Alzheimer and antioxidant activity
  10. MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana
  11. Synthesis of some chalcones derivatives series and their antituberculosis activity
  12. Luminescence of silver, thulium and ytterbium doped oxyfluoride glasses
  13. Two new naturally dimers constituent from Indonesian Sesbania grandiflora plant and their bioactivity
  14. Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)
  15. Unraveling the influence of biomaterial’s functional groups in Cd biosorption: a density functional theory calculation
  16. Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent
  17. Computational investigation of thallium interactions with functionalized multi-walled carbon nanotubes for electrochemical sensing applications
  18. Conversion of elemental phosphorus under the electron beam irradiation
  19. Advances in understanding comproportionation and disproportionation in nickel catalysis
https://doi.org/10.1515/pac-2023-1102
Keywords for this article
Dibutyltin(IV) dihydroxybenzoate; disinfectant agent; optical density; S. aureus; VCCA-2023

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Preface
  4. The virtual conference on chemistry and its applications, VCCA-2023, 7–11 August 2023
  5. Special topic papers
  6. Recovery of wipe sampling of urban surfaces contaminated with blistering chemical warfare agents
  7. Bioremediation of cadmium contaminated soil by tea waste and impact on the accumulation of Cd in Helianthus annuus
  8. Exploring the potential of Meldrum’s acid-bearing chain extenders for mechanical recycling of PET
  9. In silico and in vitro profiling of coumarins and flavonoids for anti-Alzheimer and antioxidant activity
  10. MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana
  11. Synthesis of some chalcones derivatives series and their antituberculosis activity
  12. Luminescence of silver, thulium and ytterbium doped oxyfluoride glasses
  13. Two new naturally dimers constituent from Indonesian Sesbania grandiflora plant and their bioactivity
  14. Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)
  15. Unraveling the influence of biomaterial’s functional groups in Cd biosorption: a density functional theory calculation
  16. Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent
  17. Computational investigation of thallium interactions with functionalized multi-walled carbon nanotubes for electrochemical sensing applications
  18. Conversion of elemental phosphorus under the electron beam irradiation
  19. Advances in understanding comproportionation and disproportionation in nickel catalysis
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