Response surface methodology optimization and antimicrobial activity of berberine modified trimethoprim carboxymethyl cellulose
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Gui Fu
,
Yingping Qi
Abstract
In order to solve the problem of bacterial resistance, increase the antibacterial performance and delay the aging of paper, the berberine modified trimethoprim carboxymethyl cellulose was prepared using trimethoprimethylate carboxymethyl cellulose as raw material and trimethoprimethylate lactate (TMP) as antibacterial modifier by Schiff Base reaction. At the same time, berberine (BBR) was used as graft monomer to prepare a multifunctional protective solution integrating strengthening, antibacterial and good biocompatibility. The optimal process conditions were determined by single factor experiment and response surface method. The structure and properties of the product were characterized by FT-IR, XRD, TG and SEM and the antibacterial properties were evaluated by AGAR disk diffusion method. The results showed that when the mass ratio of dialdehyde carboxymethyl cellulose and modified berberine was 7:15, reaction temperature was 40 °C, and pH was 6.0, the optimum synthetic conditions was obtained. And the minimum inhibitory concentration of the product against Staphylococcus aureus and Escherichia coli were 0.2 mg/mL, minimum diameter of antibacterial zone of 6.7 mm and 7.1 mm, respectively, with good antibacterial effect. This paper lays a foundation for further research on the safe and effective antiquities antibacterial agent, and provides a reference for its further development in paper protection.
Funding source: National Undergraduate Training Program for Innovation and Entrepreneurship
Award Identifier / Grant number: No202110459035
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This work was supported by National Undergraduate Training Program for Innovation and Entrepreneurship in 2021, No. 202110459035.
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Conflicts of interest: The authors declare no conflict of interest.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Biorefining
- Possible alternatives for using kraft lignin as activated carbon in pulp mills – a review
- Technical kraft lignin from coffee parchment
- Nitric acid-potassium hydroxide fractionation of rice straw: an integrated biorefinery initiative
- Paper technology
- The influence of fibrous suspension flow regimes on the formation of tissue paper manufactured from different furnish compositions
- Paper physics
- Assessment of paperboard large deformation at fold using digital image correlation technique
- Paper chemistry
- Response surface methodology optimization and antimicrobial activity of berberine modified trimethoprim carboxymethyl cellulose
- Packaging
- Addition of bentonite to cationic starch matrix for coating on kraftliner paper to improve grease resistance
- Recycling
- Changes in water-vapor-adsorption isotherms of pulp fibers and sheets during paper recycling, including drying of wet webs, and disintegration and sonication of dried sheets in water
- Determination of fines in recycled paper
- Disintegration of toilet papers used in shopping malls
- Nanotechnology
- Cryoslash as an effective pre-treatment to obtain nanofibrillated cellulose using ultra-fine friction grinder with kraft pulp
- Pre-treatment with calcium hydroxide and accelerated carbonation for cellulosic pulp fibrillation
- Chemical technology/modifications
- Study on manufacturing hot water-resistant PVOH coated paper by gas grafting palmitoyl chloride (II)–Control of palmitoyl chloride penetration by inorganic pigments coating
- Lignin
- Efficient and eco-friendly isolation and purification of lignin from black liquor with choline chloride-based deep eutectic solvents
- Misc
- Flocculation of alkyl ketene dimer and calcium carbonate on paper sizing and filling performance
Artikel in diesem Heft
- Frontmatter
- Biorefining
- Possible alternatives for using kraft lignin as activated carbon in pulp mills – a review
- Technical kraft lignin from coffee parchment
- Nitric acid-potassium hydroxide fractionation of rice straw: an integrated biorefinery initiative
- Paper technology
- The influence of fibrous suspension flow regimes on the formation of tissue paper manufactured from different furnish compositions
- Paper physics
- Assessment of paperboard large deformation at fold using digital image correlation technique
- Paper chemistry
- Response surface methodology optimization and antimicrobial activity of berberine modified trimethoprim carboxymethyl cellulose
- Packaging
- Addition of bentonite to cationic starch matrix for coating on kraftliner paper to improve grease resistance
- Recycling
- Changes in water-vapor-adsorption isotherms of pulp fibers and sheets during paper recycling, including drying of wet webs, and disintegration and sonication of dried sheets in water
- Determination of fines in recycled paper
- Disintegration of toilet papers used in shopping malls
- Nanotechnology
- Cryoslash as an effective pre-treatment to obtain nanofibrillated cellulose using ultra-fine friction grinder with kraft pulp
- Pre-treatment with calcium hydroxide and accelerated carbonation for cellulosic pulp fibrillation
- Chemical technology/modifications
- Study on manufacturing hot water-resistant PVOH coated paper by gas grafting palmitoyl chloride (II)–Control of palmitoyl chloride penetration by inorganic pigments coating
- Lignin
- Efficient and eco-friendly isolation and purification of lignin from black liquor with choline chloride-based deep eutectic solvents
- Misc
- Flocculation of alkyl ketene dimer and calcium carbonate on paper sizing and filling performance
