Modeling fetal cortical development by quantile regression for gestational age and head circumference: a prospective cross sectional study
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Maria Chiara Marra
,
Daniele Di Mascio
,
Francesco D’Antonio
Abstract
Objectives
To develop charts for fetal brain cortical structures following a proposed standardized methodology and using quantile regression.
Methods
Prospective cross-sectional study including 344 low-risk singleton pregnancies between 19 and 34 weeks of gestation. The depth of Sylvian (SF), Parieto-occipital (POF) and Calcarine fissures (CF) were measured on ultrasound images using a standardized technique and their changes were evaluated by quantile regression as a function of gestational age (GA) interval or head circumference (HC).
Results
The measurements of SF, POF and CF depth significantly increased with gestation. Linear models better described the changes of cortical variables with GA and HC. When the fit of sulci depth with GA and HC were compared, a close relationship was highlighted for the latter variable.
Conclusions
We provided prospective charts of fetal cortical development using quantile regression and following a strict standardized methodology These new charts may help in better identifying cases at higher risk of abnormal cortical neurodevelopment.
Funding source: Italian Ministry of University and Research
Award Identifier / Grant number: PE00000006 MNESYS PNRR
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Research ethics: The study was approved by our Institutional Ethical Board (May. 31st 2022 Protocol n° 110/2022).
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Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.
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Author contributions: All Authors provided a substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no competing of interest.
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Research funding: The study was supported by a grant of the Italian Ministry of University and Research (MUR PE00000006 MNESYS PNRR).
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Data availablity: Data available on reasonable request.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/jpm-2023-0176).
© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Obituary
- A tribute to Professor Moshe Mazor, M.D.
- Mini Review
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- Opinion Paper
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- An analysis of factors affecting survival in prenatally diagnosed omphalocele
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- Original Articles – Fetus
- Embryonic and fetal tiny pericardial fluid collections at less than 12 weeks of gestation
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- The effect of 50 GR oral glucose tolerance test on fetal celiac artery and superior mesenteric artery Doppler parameters in healthy pregnancies
- Original Articles – Neonates
- Carboxyhaemoglobin levels in infants with hypoxic ischaemic encephalopathy
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- Letter to the Editor
- Cutting of the strangulated double nuchal umbilical cord in a release of the severe shoulder dystocia: forensically justified or controversial procedure
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Artikel in diesem Heft
- Frontmatter
- Obituary
- A tribute to Professor Moshe Mazor, M.D.
- Mini Review
- Systematic review of the long-term effects of postnatal corticosteroids
- Opinion Paper
- The proposal of the novel fetal shoulder dystocia graduation: a clinical-based opinion
- Corner of Academy
- Prenatal diagnosis of bilobate placenta: incidence, risk factors and impact on pregnancy outcomes
- Original Articles – Obstetrics
- High mobility group box 1 in women with unexplained recurrent pregnancy loss
- Velamentous cord insertion in monochorionic twin pregnancies: a step forward in screening for twin to twin transfusion syndrome and birthweight discordance?
- Advanced maternal age (AMA) and 75 g oGTT glucose levels are pedictors for insulin therapy in women with gestational diabetes (GDM)
- Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study
- Increased risk of severe COVID-19 in pregnancy in a multicenter propensity score-matched study
- Comparative clinical and placental pathologic characteristics in pregnancies with and without SARS-CoV-2 infection
- An analysis of factors affecting survival in prenatally diagnosed omphalocele
- The impact of abnormal maternal body mass index during pregnancy on perinatal outcomes: a registry-based study from Qatar
- Original Articles – Fetus
- Embryonic and fetal tiny pericardial fluid collections at less than 12 weeks of gestation
- Modeling fetal cortical development by quantile regression for gestational age and head circumference: a prospective cross sectional study
- The effect of 50 GR oral glucose tolerance test on fetal celiac artery and superior mesenteric artery Doppler parameters in healthy pregnancies
- Original Articles – Neonates
- Carboxyhaemoglobin levels in infants with hypoxic ischaemic encephalopathy
- Exploring professionals’ views regarding prenatal counselling in congenital diaphragmatic hernia
- Letter to the Editor
- Cutting of the strangulated double nuchal umbilical cord in a release of the severe shoulder dystocia: forensically justified or controversial procedure
- Retraction
- Retraction of: Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial
- Retraction of: Lidocaine vs. tramadol vs. placebo wound infiltration for post-cesarean section pain relief: a randomized controlled trial
