Startseite Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study
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Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study

  • Rafael A. Caparros-Gonzalez ORCID logo EMAIL logo , Cecilia Essau , Jean-Philippe Gouin , Andres Pemau , Alejandra Galvez-Merlin und Alejandro de la Torre-Luque
Veröffentlicht/Copyright: 19. Juni 2023
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 51 Heft 9

Abstract

Objectives

Asthma is a common chronic and burdensome disease which typically begins in childhood. The aim of this study was to assess perinatal and obstetric factors which may increase the risk of developing asthma in the offspring.

Methods

Data from five consecutive waves (n=7,073 children, from birth to 15 years old) from a nationally-representative birth cohort of people born in the United Kingdom between 2000 and 2002, the Millennium Cohort Study (MCS), were used. The Kaplan–Meier survival curve was used to graphically display the risk of developing asthma from early childhood to adolescence. The Z-based Wald test was used to prove significant covariate loading.

Results

Cox regression analyzing the influence of covariates on asthma development risk showed a significant likelihood ratio test, χ2(18)=899.30, p<0.01. A parent with asthma (OR=2.02, p<0.01), a younger maternal age at delivery (OR=0.98, p<0.05), and the use of assisted reproductive technology (OR=1.43, p<0.05) were associated with an increased risk of developing asthma in the offspring.

Conclusions

Perinatal factors (a younger maternal age, assisted reproductive technology) and a parental factor (a parent with asthma) increased the risk for developing asthma in the offspring.

Keywords: assisted reproductive technology; asthma; delivery; perinatal factors; pregnancy
Corresponding author: Rafael A. Caparros-Gonzalez, PhD, Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain, Phone: +34 958 244052, Fax: +34 958248904, E-mail:

  1. Research funding: This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  2. Author contributions: ATL designed the study. RCG conducted the literature review and prepared the Introduction, and Methods section. ATL designed and conducted the analytic strategy and wrote the results section. CE and JPG helped interpreting the findings. AP and AGM drafted the discussion. All the authors reviewed and approved the final version of this manuscript. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no competing of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: All the protocols conducted in the MCS were approved by an Ethical Committee for human research. Reference: Shepherd P, Gilbert E (2019) Millennium Cohort Study. Ethical review and consent. London. https://cls.ucl.ac.uk › 2017/07PDFMillennium Cohort Study – Ethical review and consent.

References

1. Stern, J, Pier, J, Litonjua, AA. Asthma epidemiology and risk factors. seminars in immunopathology. Berlin: Springer Berlin Heidelberg; 2020.10.1007/s00281-020-00785-1Suche in Google Scholar PubMed

2. Murray, C, Foden, P, Lowe, L, Durrington, H, Custovic, A, Simpson, A. Diagnosis of asthma in symptomatic children based on measures of lung function: an analysis of data from a population-based birth cohort study. Lancet Child Adolesc Health 2017;1:114–23. https://doi.org/10.1016/s2352-4642(17)30008-1.Suche in Google Scholar

3. Han, Y, Jia, Q, Jahani, PS, Hurrel, P, Pan, C, Huang, P, et al.. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nat Commun 2020;15:1–3. https://doi.org/10.1038/s41467-020-15649-3.Suche in Google Scholar PubMed PubMed Central

4. Morales, E, Alcantara-Lopez, M, Cabezas-Herrera, J, de Diego, T, Hernandez-Caselles, T, Jimenez-Guerrero, P, et al.. On behalf of the NELA study group. The nutrition in early life and asthma (NELA) birth cohort study: rationale, design, and methods. Paediatr Perinat Epidemiol 2022;36:310–24. https://doi.org/10.1111/ppe.12826.Suche in Google Scholar PubMed

5. Silver, JD, Sutherland, MF, Johnston, FH, Lampugnani, E, McCarthy, M, Jacobs, S, et al.. Seasonal asthma in Melbourne, Australia, and some observations on the occurrence of thunderstorm asthma and its predictability. PLoS One 2018;13:e0194929. https://doi.org/10.1371/journal.pone.0194929.Suche in Google Scholar PubMed PubMed Central

6. Brzozowska, A, Podlecka, D, Jankowska, A, Król, A, Kaleta, D, Trafalska, E, et al.. Maternal diet during pregnancy and risk of allergic diseases in children up to 7–9 years old from polish mother and child cohort study. Environ Res 2022;208:112682. https://doi.org/10.1016/j.envres.2022.112682.Suche in Google Scholar PubMed

7. Morales, E, Strachan, D, Asher, I, Ellwood, P, Pearce, N, Garcia-Marcos, L. Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: ISAAC phase III. Thorax 2019;74:531–8. https://doi.org/10.1136/thoraxjnl-2018-212668.Suche in Google Scholar PubMed

8. Greenough, A, Milner, AD. Early origins of respiratory disease. J Perinat Med 2023;51:11–9. https://doi.org/10.1515/jpm-2022-0257.Suche in Google Scholar PubMed

9. Barker, DJ. Fetal origins of coronary heart disease. BMJ 1995;311:171–4. https://doi.org/10.1136/bmj.311.6998.171.Suche in Google Scholar PubMed PubMed Central

10. Caparros-Gonzalez, RA, Alderdice, F. The COVID-19 pandemic and perinatal mental health. J Reprod Infant Psychol 2020;38:223–5. https://doi.org/10.1080/02646838.2020.1786910.Suche in Google Scholar PubMed

11. Glover, V. Annual research review: prenatal stress and the origins of psychopathology: an evolutionary perspective. J Child Psychol Psychiatry 2011;52:356–67. https://doi.org/10.1111/j.1469-7610.2011.02371.x.Suche in Google Scholar PubMed

12. Fernandez-Rodriguez, B, Gomez, AR, Jimenez Moreno, B, De Alba, C, Galindo, A, Villalain, C, et al.. Smoking influence on early and late fetal growth. J Perinat Med 2022;50:200–6. https://doi.org/10.1515/jpm-2021-0226.Suche in Google Scholar PubMed

13. Glover, V. Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol 2014;28:25–35. https://doi.org/10.1016/j.bpobgyn.2013.08.017.Suche in Google Scholar PubMed

14. Duijts, L. Fetal and infant origins of asthma. Eur J Epidemiol 2012;27:5–14. https://doi.org/10.1007/s10654-012-9657-y.Suche in Google Scholar PubMed PubMed Central

15. Rakers, F, Rupprecht, S, Dreiling, M, Bergmeier, C, Witte, OW, Schwab, M. Transfer of maternal psychosocial stress to the fetus. Neurosci Biobehav Rev 2020;117:185–97. https://doi.org/10.1016/j.neubiorev.2017.02.019.Suche in Google Scholar PubMed

16. Hyppönen, E. Intergenerational BMI association: is there a role for fetal programming? Int J Epidemiol 2019;49:244–5. https://doi.org/10.1093/ije/dyz186.Suche in Google Scholar PubMed

17. Von Hertzen, LC. Maternal stress and T-cell differentiation of the developing immune system: possible implications for the development of asthma and atopy. J Allergy Clin Immunol 2002;109:923–8. https://doi.org/10.1067/mai.2002.124776.Suche in Google Scholar PubMed

18. MacArthur, J, Bowler, E, Cerezo, M, Gil, L, Hall, P, Hastings, E, et al.. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res 2017;45:D896–901. https://doi.org/10.1093/nar/gkw1133.Suche in Google Scholar PubMed PubMed Central

19. Zacharasiewicz, A. Maternal smoking in pregnancy and its influence on childhood asthma. ERJ Open Research 2016;2:1–9. https://doi.org/10.1183/23120541.00042-2016.Suche in Google Scholar PubMed PubMed Central

20. Cookson, H, Granell, R, Joinson, C, Ben-Shlomo, Y, Henderson, AJ. Mothers’ anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol 2009;123:847–53. https://doi.org/10.1016/j.jaci.2009.01.042.Suche in Google Scholar PubMed PubMed Central

21. Van de Loo, KFE, Van Gelder, MM, Roukema, J, Roeleveld, N, Merkus, PJ, Verhaak, CM. Prenatal maternal psychological stress and childhood asthma and wheezing: a meta-analysis. Eur Respir J 2016;47:133–46. https://doi.org/10.1183/13993003.00299-2015.Suche in Google Scholar PubMed

22. Al-Hussainy, A, Raihan, M. Consequences of maternal psychological stress during pregnancy for the risk of asthma in the offspring. Scand J Immunol 2021;93:e12919. https://doi.org/10.1111/sji.12919.Suche in Google Scholar PubMed

23. Magnus, MC, Wright, RJ, Røysamb, E, Parr, CL, Karlstad, Ø, Page, CM, et al.. Association of maternal psychosocial stress with increased risk of asthma development in offspring. Am J Epidemiol 2018;187:1199–209. https://doi.org/10.1093/aje/kwx366.Suche in Google Scholar PubMed PubMed Central

24. Huizink, AC, Bartels, M, Rose, RJ, Pulkkinen, L, Eriksson, CJ, Kaprio, J. Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring. J Epidemiol Community Health 2008;62:e5. https://doi.org/10.1136/jech.2007.060350.Suche in Google Scholar PubMed PubMed Central

25. Khashan, AS, Abel, KM, McNamee, R, Pedersen, M, Webb, R, Baker, P, et al.. Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatr 2008;65:146–52. https://doi.org/10.1001/archgenpsychiatry.2007.20.Suche in Google Scholar PubMed

26. Martin, C, Jones, C, Marshall, CA, Huang, C, Reeve, J, Felming, M, et al.. Fear of childbirth measurement: appraisal of the content overlap of four instruments. J Reprod Infant Psychol 2020;24:1–3. https://doi.org/10.1080/02646838.2020.1861226.Suche in Google Scholar PubMed

27. Reyman, M, Van Houten, MA, Baarle, D, Bosch, A, Man, W, Chu, M, et al.. Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life. Nat Commun 2019;10:1–12. https://doi.org/10.1038/s41467-019-13014-7.Suche in Google Scholar PubMed PubMed Central

28. Thompson, AL. Caesarean delivery, immune function and inflammation in early life among Ecuadorian infants and young children. J Dev Orig Health Dis 2019;10:555–62. https://doi.org/10.1017/s2040174419000047.Suche in Google Scholar PubMed PubMed Central

29. Wong, E, Lui, K, Day, AS, Leach, ST. Manipulating the neonatal gut microbiome: current understanding and future perspectives. Arch Dis Child Fetal Neonatal 2022;107:346–50. https://doi.org/10.1136/archdischild-2021-321922.Suche in Google Scholar PubMed PubMed Central

30. Rusconi, F, Zugna, D, Annesi-Maesano, I, Baïz, N, Barros, H, Correia, S, et al.. Mode of delivery and asthma at school age in 9 European birth cohorts. Am J Epidemiol 2017;185:465–73. https://doi.org/10.1093/aje/kwx021.Suche in Google Scholar PubMed

31. Thursby, E, Juge, N. Introduction to the human gut microbiota. Biochem J 2017;474:1823–36. https://doi.org/10.1042/bcj20160510.Suche in Google Scholar PubMed PubMed Central

32. Rutayisire, E, Huang, K, Liu, Y, Tao, F. The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants’ life: a systematic review. BMC Gastroenterol 2016;16:1–12. https://doi.org/10.1186/s12876-016-0498-0.Suche in Google Scholar PubMed PubMed Central

33. Green, CA, Yeates, D, Goldacre, A, Sande, C, Parslow, R, McShane, P, et al.. Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma. Arch Dis Child 2016;101:140–6. https://doi.org/10.1136/archdischild-2015-308723.Suche in Google Scholar PubMed PubMed Central

34. Davidson, R, Roberts, SE, Wotton, CJ, Goldacre, MJ. Influence of maternal and perinatal factors on subsequent hospitalisation for asthma in children: evidence from the Oxford record linkage study. BMC Pulm Med 2010;10:1–8. https://doi.org/10.1186/1471-2466-10-14.Suche in Google Scholar PubMed PubMed Central

35. Joshi, H, Fitzsimons, E. The UK Millennium Cohort Study: the making of a multi-purpose resource for social science and policy in the UK. Longit Life Course Stud 2016;7:409–30.10.14301/llcs.v7i4.410Suche in Google Scholar

36. Connelly, R, Platt, L. Cohort profile: UK Millennium cohort study (mcs). Int J Epidemiol 2014;43:1719–25. https://doi.org/10.1093/ije/dyu001.Suche in Google Scholar PubMed

37. Therneau, TM, Lumley, T. Survival: survival analysis. In: R packag version 239-4. The R Foundation; 2016:128 p.Suche in Google Scholar

38. Mirzakhani, H, Carey, VJ, McElrath, TF, Qiu, W, Hollis, B, O`Connor, G, et al.. Impact of preeclampsia on the relationship between maternal asthma and offspring asthma. An observation from the VDAART clinical trial. Am J Respir Crit Care Med 2019;199:32–42. https://doi.org/10.1164/rccm.201804-0770oc.Suche in Google Scholar PubMed PubMed Central

39. Lim, RH, Lester, K, Morten, D. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS One 2010;5:e10134. https://doi.org/10.1371/journal.pone.0010134.Suche in Google Scholar PubMed PubMed Central

40. Arshad, SH, Karmaus, W, Zhang, H, Holloway, JW. Multigenerational cohorts in patients with asthma and allergy. J Allergy Clin Immunol 2017;139:415–21. https://doi.org/10.1016/j.jaci.2016.12.002.Suche in Google Scholar PubMed PubMed Central

41. Fall, CHD, Singh, SH, Osmond, C, Restrepo-Mendez, M, Victoria, C, Martorell, R, et al.. Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). Lancet Global Health 2015;3:e366–77. https://doi.org/10.1016/s2214-109x(15)00038-8.Suche in Google Scholar

42. Geier, DA, Janet, KK, Mark, RG. Demographic and neonatal risk factors for childhood asthma in the USA. J Matern Fetal Neonatal Med 2019;32:833–7. https://doi.org/10.1080/14767058.2017.1393068.Suche in Google Scholar PubMed

43. Bergh, C, Ulla-Britt, W. Long-term health of children conceived after assisted reproductive technology. Ups J Med Sci 2020;125:152–7. https://doi.org/10.1080/03009734.2020.1729904.Suche in Google Scholar PubMed PubMed Central

44. Källén, B, Finnström, O, Nygren, KG, Olausson, PO. Asthma in Swedish children conceived by in vitro fertilisation. Arch Dis Child 2013;98:92–6. https://doi.org/10.1136/archdischild-2012-301822.Suche in Google Scholar PubMed

45. Carson, C, Sacker, A, Kelly, Y, Redshaw, M, Kurinczuk, JJ, Quigley, MA. Asthma in children born after infertility treatment: findings from the UK millennium cohort study. Hum Reprod 2013;28:471–9. https://doi.org/10.1093/humrep/des398.Suche in Google Scholar PubMed PubMed Central

46. Bailey, A, Ellis-Caird, H, Croft, C. Living through unsuccessful conception attempts: a grounded theory of resilience among women undergoing fertility treatment. J Reprod Infant Psychol 2017;35:1–10. https://doi.org/10.1080/02646838.2017.1320366.Suche in Google Scholar PubMed

47. Toftager, M, Sylvest, R, Schmidt, L, Bogstad, J, Lossl, K, Praetorious, L, et al.. Quality of life and psychosocial and physical well-being among 1,023 women during their first assisted reproductive technology treatment: secondary outcome to a randomized controlled trial comparing gonadotropin-releasing hormone (GnRH) antagonist and GnRH agonist protocols. Fertil Steril 2018;109:154–64. https://doi.org/10.1016/j.fertnstert.2017.09.020.Suche in Google Scholar PubMed

48. Grech, V, Miriam, G. Assisted reproductive technology and multiple pregnancy in Malta—a population based study. Early Hum Dev 2021;157:105378. https://doi.org/10.1016/j.earlhumdev.2021.105378.Suche in Google Scholar PubMed

49. Caparros-Gonzalez, RA, Romero-Gonzalez, B, Quesada-Soto, JM, Gonzalez-Perez, R, Marinas-Lirola, JC, Peralta-Ramírez, MI. Maternal hair cortisol levels affect neonatal development among women conceiving with assisted reproductive technology. J Reprod Infant Psychol 2019;37:480–98. https://doi.org/10.1080/02646838.2019.1578949.Suche in Google Scholar PubMed

50. Tsabouri, S, Lavasidis, G, Efstathiadou, A, Papasavva, M, Bellou, V, Bergantini, H, et al.. Association between childhood asthma and history of assisted reproduction techniques: a systematic review and meta-analysis. Eur J Pediatr 2021;180:2007–17. https://doi.org/10.1007/s00431-021-03975-7.Suche in Google Scholar PubMed

51. Van Sieleghem, S, Danckaerts, M, Rieken, R, Okkerse, J, Jonge, E, Bramer, W, et al.. Childbirth related PTSD and its association with infant outcome: a systematic review. Early Hum Dev 2022;174:105667. https://doi.org/10.1016/j.earlhumdev.2022.105667.Suche in Google Scholar PubMed

52. Hartman, CA, Richards, JS, Vrijen, C, Oldehinkel, J, Oerlemans, AM, Kretschmer, T, et al.. Cohort profile update: the tracking adolescents’ individual lives survey (TRAILS). Int J Epidemiol 2022;44:76–n. https://doi.org/10.1093/ije/dyu225.Suche in Google Scholar PubMed PubMed Central

53. Dalbye, R, Aursund, I, Volent, V, Eggebø, TM, Øian, P, Bernitz, S. Associations between duration of active second stage of labour and adverse maternal and neonatal outcomes: a cohort study of nulliparous women with spontaneous onset of labour. Sex Reprod Health 2021;30:100657. https://doi.org/10.1016/j.srhc.2021.100657.Suche in Google Scholar PubMed

54. Abalos, E, Oladapo, OT, Chamillard, M, Diaz, V, Pasquale, J, Bonet, M, et al.. Duration of spontaneous labour in ‘low-risk’women with ‘normal’perinatal outcomes: a systematic review. Eur J Obstet Gynecol Reprod Biol 2018;223:123–32. https://doi.org/10.1016/j.ejogrb.2018.02.026.Suche in Google Scholar PubMed PubMed Central

55. Xu, B, Pekkanen, J, Järvelin, MR. Obstetric complications and asthma in childhood. J Asthma 2000;37:589–94. https://doi.org/10.3109/02770900009090814.Suche in Google Scholar PubMed

Received: 2022-11-09
Accepted: 2023-04-29
Published Online: 2023-06-19
Published in Print: 2023-11-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Obituary
  3. A tribute to Professor Moshe Mazor, M.D.
  4. Mini Review
  5. Systematic review of the long-term effects of postnatal corticosteroids
  6. Opinion Paper
  7. The proposal of the novel fetal shoulder dystocia graduation: a clinical-based opinion
  8. Corner of Academy
  9. Prenatal diagnosis of bilobate placenta: incidence, risk factors and impact on pregnancy outcomes
  10. Original Articles – Obstetrics
  11. High mobility group box 1 in women with unexplained recurrent pregnancy loss
  12. Velamentous cord insertion in monochorionic twin pregnancies: a step forward in screening for twin to twin transfusion syndrome and birthweight discordance?
  13. Advanced maternal age (AMA) and 75 g oGTT glucose levels are pedictors for insulin therapy in women with gestational diabetes (GDM)
  14. Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study
  15. Increased risk of severe COVID-19 in pregnancy in a multicenter propensity score-matched study
  16. Comparative clinical and placental pathologic characteristics in pregnancies with and without SARS-CoV-2 infection
  17. An analysis of factors affecting survival in prenatally diagnosed omphalocele
  18. The impact of abnormal maternal body mass index during pregnancy on perinatal outcomes: a registry-based study from Qatar
  19. Original Articles – Fetus
  20. Embryonic and fetal tiny pericardial fluid collections at less than 12 weeks of gestation
  21. Modeling fetal cortical development by quantile regression for gestational age and head circumference: a prospective cross sectional study
  22. The effect of 50 GR oral glucose tolerance test on fetal celiac artery and superior mesenteric artery Doppler parameters in healthy pregnancies
  23. Original Articles – Neonates
  24. Carboxyhaemoglobin levels in infants with hypoxic ischaemic encephalopathy
  25. Exploring professionals’ views regarding prenatal counselling in congenital diaphragmatic hernia
  26. Letter to the Editor
  27. Cutting of the strangulated double nuchal umbilical cord in a release of the severe shoulder dystocia: forensically justified or controversial procedure
  28. Retraction
  29. Retraction of: Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial
  30. Retraction of: Lidocaine vs. tramadol vs. placebo wound infiltration for post-cesarean section pain relief: a randomized controlled trial
https://doi.org/10.1515/jpm-2022-0543
Schlagwörter für diesen Artikel
assisted reproductive technology; asthma; delivery; perinatal factors; pregnancy

Artikel in diesem Heft

  1. Frontmatter
  2. Obituary
  3. A tribute to Professor Moshe Mazor, M.D.
  4. Mini Review
  5. Systematic review of the long-term effects of postnatal corticosteroids
  6. Opinion Paper
  7. The proposal of the novel fetal shoulder dystocia graduation: a clinical-based opinion
  8. Corner of Academy
  9. Prenatal diagnosis of bilobate placenta: incidence, risk factors and impact on pregnancy outcomes
  10. Original Articles – Obstetrics
  11. High mobility group box 1 in women with unexplained recurrent pregnancy loss
  12. Velamentous cord insertion in monochorionic twin pregnancies: a step forward in screening for twin to twin transfusion syndrome and birthweight discordance?
  13. Advanced maternal age (AMA) and 75 g oGTT glucose levels are pedictors for insulin therapy in women with gestational diabetes (GDM)
  14. Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study
  15. Increased risk of severe COVID-19 in pregnancy in a multicenter propensity score-matched study
  16. Comparative clinical and placental pathologic characteristics in pregnancies with and without SARS-CoV-2 infection
  17. An analysis of factors affecting survival in prenatally diagnosed omphalocele
  18. The impact of abnormal maternal body mass index during pregnancy on perinatal outcomes: a registry-based study from Qatar
  19. Original Articles – Fetus
  20. Embryonic and fetal tiny pericardial fluid collections at less than 12 weeks of gestation
  21. Modeling fetal cortical development by quantile regression for gestational age and head circumference: a prospective cross sectional study
  22. The effect of 50 GR oral glucose tolerance test on fetal celiac artery and superior mesenteric artery Doppler parameters in healthy pregnancies
  23. Original Articles – Neonates
  24. Carboxyhaemoglobin levels in infants with hypoxic ischaemic encephalopathy
  25. Exploring professionals’ views regarding prenatal counselling in congenital diaphragmatic hernia
  26. Letter to the Editor
  27. Cutting of the strangulated double nuchal umbilical cord in a release of the severe shoulder dystocia: forensically justified or controversial procedure
  28. Retraction
  29. Retraction of: Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial
  30. Retraction of: Lidocaine vs. tramadol vs. placebo wound infiltration for post-cesarean section pain relief: a randomized controlled trial
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