Umbilical cord blood hematological parameters in predicting early onset neonatal sepsis (EOS) – a prospective cohort study

Smrithi Marie Samson; Chandramohan Anandhi; Rathi Sharmila Ramar

doi:10.1515/jpm-2023-0100

Artikel

Umbilical cord blood hematological parameters in predicting early onset neonatal sepsis (EOS) – a prospective cohort study

Smrithi Marie Samson , Chandramohan Anandhi und Rathi Sharmila Ramar

Veröffentlicht/Copyright: 20. Oktober 2023

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Aus der Zeitschrift Journal of Perinatal Medicine Band 52 Heft 1

Abstract

Objectives

In low and middle income countries, there is a need for affordable and accurate biomarkers to identify neonates at risk of early onset neonatal sepsis (EOS). Cord blood hematological parameters if reliable and accurate for the detection of EOS are cost effective and can reduce the need for repeated venipuncture in the neonate.

Methods

In this prospective cohort study, the umbilical cord parameters of newborns with gestational age >34 weeks were collected. These neonates were followed up for 72 h and septic screen was employed in those babies who had risk factors or developed clinical features of sepsis. The cord blood parameters of the normal newborn and those who had sepsis were analyzed.

Results

A total of 513 neonates were enrolled for the study, 32 required septic screening of whom 13 neonates were found to meet the criteria for sepsis: either blood culture positive or sepsis screen positive with clinical features. Cord blood parameters were analyzed using independent t test. Red cell distribution width (RDW) and band cells were statistically significant (p 0.007 and 0.009 respectively) between the septic and normal neonates. Increased RDW had a sensitivity of 61.54 %, specificity of 54.60 %. Increased band cells with a cut off of >15 cells had a sensitivity of 7.7 % with specificity of 100 % with higher numbers in septic neonates. Increased RDW and band cells in combination had sensitivity of 61.54 % and specificity of 54.6 %.

Conclusions

RDW and band cell can be potential markers of EOS in cord blood but require further study in a larger population.

Keywords: early onset sepsis; umbilical cord blood; RDW; band cells

Corresponding author: Dr. Rathi Sharmila Ramar, Professor, Department of Pediatrics, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeet University, Pondicherry, 607402, India, E-mail: rathiramar@gmail.com

Research ethics: Approved by Institutional Human Ethics Committee (IHEC-MGMCRI/Res/01/2020/63/IHEC/286).
Informed consent: Informed consent was obtained from all individuals included in this study.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: The authors state no conflict of interest.
Research funding: None declared.
Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2023-03-05

Accepted: 2023-09-04

Published Online: 2023-10-20

Published in Print: 2024-01-29

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Artikel in diesem Heft

https://doi.org/10.1515/jpm-2023-0100

Schlagwörter für diesen Artikel

early onset sepsis; umbilical cord blood; RDW; band cells