The association between maternal colonization with Group B Streptococcus and infectious morbidity following transcervical Foley catheter-assisted labor induction

Alon Ben-David; Raanan Meyer; Shali Mazaki-Tovi

doi:10.1515/jpm-2023-0212

Article

The association between maternal colonization with Group B Streptococcus and infectious morbidity following transcervical Foley catheter-assisted labor induction

Alon Ben-David , Raanan Meyer and Shali Mazaki-Tovi

Published/Copyright: October 18, 2023

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From the journal Journal of Perinatal Medicine Volume 52 Issue 1

Abstract

Objectives

To determine whether maternal colonization with Group B Streptococcus increases the risk for infectious morbidity following transcervical Foley catheter-assisted cervical ripening.

Methods

A retrospective cohort study comparing infectious morbidity and other clinical outcomes by Group B Streptococcus colonization status between all women with singleton pregnancies who underwent Foley catheter-assisted cervical ripening labor induction at a single tertiary medical center during 2011–2021. Multivariable logistic regression explored the relationship between Group B Streptococcus colonization to adverse outcomes while adjusting for relevant clinical variables.

Results

A total of 4,409 women were included of whom 886 (20.1 %) were considered Group B Streptococcus carriers and 3,523 (79.9 %) were not. Suspected neonatal sepsis rate was similar between Group B Streptococcus carriers and non-carriers (5.2 vs. 5.0 %, respectively, p=0.78). Neonatal sepsis was confirmed in 7 (0.02 %) cases, all born to non-carriers. Group B Streptococcus carriers had a higher rate of maternal bacteremia compared to non-carriers (1.2 vs. 0.5 %, respectively, p=0.01). Group B Streptococcus colonization was independently associated with maternal bacteremia (adjusted odds ratio 3.05; 95 %CI 1.39, 6.66).

Conclusions

Group B Streptococcus colonization among women undergoing Foley catheter-assisted cervical ripening does not seem to increase the risk for neonatal infection. However, higher rates of maternal bacteremia were detected.

Keywords: Group B Streptococcus; neonatal sepsis; maternal infection; transcervical Foley catheter; cervical ripening

Corresponding author: Alon Ben-David, MD, MPH, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer 52621, Ramat Gan, Israel; and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Phone: +972 3 5302773, Fax: +972 3 5302932, E-mail: Alon.BenDavid@sheba.health.gov.il

Research ethics: The study was conducted in accordance with the decleration of Helsinki (as revised in 2013), and has been approved by the authors’ Institutional Review Board (7415-20-SMC).
Informed consent: Not applicaple.
Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: The authors state no conflict of interest.
Research funding: None declared.
Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2023-05-24

Accepted: 2023-09-12

Published Online: 2023-10-18

Published in Print: 2024-01-29

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Articles in the same Issue

https://doi.org/10.1515/jpm-2023-0212

Keywords for this article

Group B Streptococcus; neonatal sepsis; maternal infection; transcervical Foley catheter; cervical ripening