Home Medicine Effect of third trimester maternal vitamin D levels on placental weight to birth weight ratio in uncomplicated pregnancies
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Effect of third trimester maternal vitamin D levels on placental weight to birth weight ratio in uncomplicated pregnancies

  • Mehmet Mete Kirlangic ORCID logo EMAIL logo , Osman Sertac Sade ORCID logo and Mefkure Eraslan Sahin ORCID logo
Published/Copyright: December 13, 2022
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 51 Issue 5

Abstract

Objectives

Vitamin D has critical role for the fetal and placental development. Today, placental weight (PW), fetal birth weight (BW), and the PW/BW ratio are used as markers of fetal development. The aim of this study is to evaluate the relationship between vitamin D levels and these markers in uncomplicated pregnancies.

Methods

This study included 108 women with uncomplicated pregnancies, defined as full-term and healthy pregnancies without perinatal complications. Vitamin D levels <12 ng/mL were classified as deficient, 12–20 ng/mL as insufficient, and >20 ng/mL as normal. Postnatal BW and PW were compared according to maternal serum vitamin D levels.

Results

Maternal age, maternal height, maternal weight, body mass index, nulliparity, gestational age at delivery, mode of delivery, and fetal gender were similar between groups. Postnatal BW, PW, fetal height at birth, and fetal head circumference parameters were similar between the groups. The PW/BW ratio was 21.77±2.20 in the vitamin D deficient group, 21.20±2.40 in the insufficient group, and 19.98±2.37 in the normal group (p=0.012). In addition, there was a significant negative correlation between vitamin D level and the PW/BW ratio (p=0.012, r=0.031).

Conclusions

Our results indicated that PW/BW ratio which is the marker for prediction adverse perinatal outcomes were significantly increased in the presence of vitamin D deficiency and insufficiency.

Keywords: birth weight; placental weight; PW/BW ratio; uncomplicated pregnancies; vitamin D
Corresponding author: Mehmet Mete Kirlangic, Department of Obstetrics and Gynecology, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Soğanlık Yeni neighborhood, Aheste Street, Çukurova Balkon apartment, B Block No.50 Kartal, Istanbul, Turkiye, Phone: +905064641819, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: This study is designed as prospective and cross-sectional. Approval was obtained from the Marmara University Faculty of Medicine Ethics Committee for the study (approval no: 09.2021.98). It was conducted in accordance with the Helsinki declaration.

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Received: 2022-09-04
Accepted: 2022-11-14
Published Online: 2022-12-13
Published in Print: 2023-06-27

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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  25. Letters to the Editor
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  27. Pregnancy associated plasma protein-A for the prediction of small for gestational age
  28. Reply to: Pregnancy associated plasma protein-A for the prediction of small for gestational age
https://doi.org/10.1515/jpm-2022-0432
Keywords for this article
birth weight; placental weight; PW/BW ratio; uncomplicated pregnancies; vitamin D

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Disquiet concerning cesarean birth
  4. Prenatal care and pregnancy outcome among incarcerated pregnant individuals in the United States: a systematic review and meta-analysis
  5. Corner of Academy
  6. Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology?
  7. Original Articles – Obstetrics
  8. Did the first wave of the COVID-19 pandemic impact the cesarean delivery rate? A retrospective cohort study at a primary care center in Switzerland
  9. Hypertensive disorders of pregnancy and severe acute respiratory syndrome coronavirus-2 infection
  10. Hidden in plain sight in the delivery room – the Apgar score is biased
  11. Comparison of phase rectified signal averaging and short term variation in predicting perinatal outcome in early onset fetal growth restriction
  12. Serum levels of kynurenine in pregnancies with fetal growth restriction and oligohydramnios
  13. Effect of third trimester maternal vitamin D levels on placental weight to birth weight ratio in uncomplicated pregnancies
  14. One-third of patients with eclampsia at term do not have an abnormal angiogenic profile
  15. Chorioangioma: a single tertiary care center retrospective study
  16. A prospective cohort study: can advanced ultrasonography replace magnetic resonance imaging in the diagnosis of placental adhesion disorders?
  17. Original Articles – Fetus
  18. Fetal left brachiocephalic vein diameters in normal and growth restricted fetuses
  19. Functional assessment of atrial wall excursion and foramen ovale flap tracings in 3rd trimester as predictor of short-term hemodynamic stability in congenital heart defects fetuses
  20. Original Articles – Neonates
  21. Developing a new pediatric extracorporeal membrane oxygenation (ECMO) program
  22. Patterns of placental injury in various types of fetal congenital heart disease
  23. Short Communication
  24. Prenatal care in the era of economic collapse
  25. Letters to the Editor
  26. Does fetus feel stress or pain on uterine contraction?
  27. Pregnancy associated plasma protein-A for the prediction of small for gestational age
  28. Reply to: Pregnancy associated plasma protein-A for the prediction of small for gestational age
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