Hypertensive disorders of pregnancy and severe acute respiratory syndrome coronavirus-2 infection
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Cara S. Wetcher
,
Moti Gulersen
Abstract
Objectives
We aimed to determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with an increased risk of hypertensive disorders of pregnancy (HDP).
Methods
A multicenter retrospective cohort study of all pregnant patients who had SARS-CoV-2 testing and delivered in a large health system between March 2020 and March 2021. Cases were stratified into two groups: patients who tested positive for SARS-CoV-2 during pregnancy vs. patients who tested negative. The primary outcome of HDP, defined as a composite of gestational hypertension, preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP Syndrome), and eclampsia by standard criteria, was compared between the two groups. Statistical analysis included multivariable logistic regression to adjust for potential confounders such as maternal demographics and comorbidities. Patient ZIP codes were linked to neighborhood-level data from the US Census Bureau’s American Community Survey.
Results
Of the 22,438 patients included, 1,653 (7.4%) tested positive for SARS-CoV-2 infection. Baseline demographics such as age, body mass index, race, ethnicity, insurance type, neighborhood-built environmental and socioeconomic status, nulliparity, and pregestational diabetes differed significantly between the two groups. SARS-CoV- 2 infection in pregnancy was not associated with an increased risk of HDP compared to those without infection (14.9 vs. 14.8%; aOR 1.06 95% CI 0.90–1.24).
Conclusions
In this large cohort that included a universally-tested population with several socioeconomic indicators, SARS-CoV-2 infection in pregnancy was not associated with an increased risk of HDP.
Acknowledgments
We would like to acknowledge the contributions of the Northwell Health COVID 19 Research Consortium.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Disquiet concerning cesarean birth
- Prenatal care and pregnancy outcome among incarcerated pregnant individuals in the United States: a systematic review and meta-analysis
- Corner of Academy
- Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology?
- Original Articles – Obstetrics
- Did the first wave of the COVID-19 pandemic impact the cesarean delivery rate? A retrospective cohort study at a primary care center in Switzerland
- Hypertensive disorders of pregnancy and severe acute respiratory syndrome coronavirus-2 infection
- Hidden in plain sight in the delivery room – the Apgar score is biased
- Comparison of phase rectified signal averaging and short term variation in predicting perinatal outcome in early onset fetal growth restriction
- Serum levels of kynurenine in pregnancies with fetal growth restriction and oligohydramnios
- Effect of third trimester maternal vitamin D levels on placental weight to birth weight ratio in uncomplicated pregnancies
- One-third of patients with eclampsia at term do not have an abnormal angiogenic profile
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- A prospective cohort study: can advanced ultrasonography replace magnetic resonance imaging in the diagnosis of placental adhesion disorders?
- Original Articles – Fetus
- Fetal left brachiocephalic vein diameters in normal and growth restricted fetuses
- Functional assessment of atrial wall excursion and foramen ovale flap tracings in 3rd trimester as predictor of short-term hemodynamic stability in congenital heart defects fetuses
- Original Articles – Neonates
- Developing a new pediatric extracorporeal membrane oxygenation (ECMO) program
- Patterns of placental injury in various types of fetal congenital heart disease
- Short Communication
- Prenatal care in the era of economic collapse
- Letters to the Editor
- Does fetus feel stress or pain on uterine contraction?
- Pregnancy associated plasma protein-A for the prediction of small for gestational age
- Reply to: Pregnancy associated plasma protein-A for the prediction of small for gestational age
Articles in the same Issue
- Frontmatter
- Reviews
- Disquiet concerning cesarean birth
- Prenatal care and pregnancy outcome among incarcerated pregnant individuals in the United States: a systematic review and meta-analysis
- Corner of Academy
- Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology?
- Original Articles – Obstetrics
- Did the first wave of the COVID-19 pandemic impact the cesarean delivery rate? A retrospective cohort study at a primary care center in Switzerland
- Hypertensive disorders of pregnancy and severe acute respiratory syndrome coronavirus-2 infection
- Hidden in plain sight in the delivery room – the Apgar score is biased
- Comparison of phase rectified signal averaging and short term variation in predicting perinatal outcome in early onset fetal growth restriction
- Serum levels of kynurenine in pregnancies with fetal growth restriction and oligohydramnios
- Effect of third trimester maternal vitamin D levels on placental weight to birth weight ratio in uncomplicated pregnancies
- One-third of patients with eclampsia at term do not have an abnormal angiogenic profile
- Chorioangioma: a single tertiary care center retrospective study
- A prospective cohort study: can advanced ultrasonography replace magnetic resonance imaging in the diagnosis of placental adhesion disorders?
- Original Articles – Fetus
- Fetal left brachiocephalic vein diameters in normal and growth restricted fetuses
- Functional assessment of atrial wall excursion and foramen ovale flap tracings in 3rd trimester as predictor of short-term hemodynamic stability in congenital heart defects fetuses
- Original Articles – Neonates
- Developing a new pediatric extracorporeal membrane oxygenation (ECMO) program
- Patterns of placental injury in various types of fetal congenital heart disease
- Short Communication
- Prenatal care in the era of economic collapse
- Letters to the Editor
- Does fetus feel stress or pain on uterine contraction?
- Pregnancy associated plasma protein-A for the prediction of small for gestational age
- Reply to: Pregnancy associated plasma protein-A for the prediction of small for gestational age
