Adverse perinatal outcomes of chlamydia infections: an ongoing challenge
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Yael Eliner
,
Moti Gulersen
,
Amos Grunebaum
Abstract
Objectives
Chlamydia trachomatis is one of the most common sexually transmitted diseases in the world, but there are limited data on its impact on perinatal outcomes. Our objective was to investigate the association between chlamydia infections and adverse perinatal outcomes.
Methods
This is a retrospective analysis of the United States Centers for Disease Control and Prevention natality live birth database for the years 2016–2019. The rates of adverse perinatal outcomes were compared between patients with a chlamydia infection during pregnancy and patients without such infection, using Pearson’s chi-square test with the Bonferroni adjustment. A multivariate logistic regression was then used to adjust outcomes for potential confounders.
Results
Chlamydia infections were associated with small, but statistically significant, increased odds of preterm birth (<37 weeks), early preterm birth (<32 weeks), low birthweight (<2,500 g), congenital anomalies, low 5-min Apgar score (<7), neonatal intensive care unit admission, immediate neonatal ventilation, prolonged (>6 h) neonatal ventilation, and neonatal antibiotic treatment for suspected sepsis.
Conclusions
Chlamydia infections during pregnancy are associated with adverse perinatal outcomes. These results call for increased education regarding the potential risks of pregnancies with a chlamydia infection, as well as for increased antenatal surveillance and post-natal pediatric assessment in these pregnancies.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable. Informed consent was not required, as the de-identified data are publicly available through a data use agreement with the National Center for Health Statistics.
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Ethical approval: Not applicable. Institutional Review Board approval was not required, as the de-identified data are publicly available through a data use agreement with the National Center for Health Statistics.
References
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- WAPM Guideline
- The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine foundation
- Corner of Academy
- Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of the late preterm delivery regardless of the membrane status
- Original Articles – Obstetrics
- Comparison of cardiac morphology and function in small for gestational age fetuses and fetuses with late-onset fetal growth retardation
- Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study
- One year into the SARS-CoV-2 pandemic: perinatal outcome and data on the transmission of 116 pregnant women
- Adverse perinatal outcomes of chlamydia infections: an ongoing challenge
- Pregnancy outcomes with differences in grain consumption: a randomized controlled trial
- Who needs prenatal counselling with a pediatric surgeon? Experience from a large tertiary care university hospital
- To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study
- Placental characteristics of selective intrauterine growth restriction with changing patterns in umbilical artery Doppler flow in monochorionic diamniotic twins
- Association between cesarean section rate and maternal age in twin pregnancies
- Maternal and neonatal outcomes associated with delivery techniques for impacted fetal head at cesarean section: a systematic review and meta-analysis
- Experience with direct oral anticoagulants in pregnancy – a systematic review
- Nasal bone in fetal aneuploidy risk assessment: are they independent markers in the first and second trimesters?
- Effects of music on sleep quality and comfort levels of pregnant women
- Original Articles – Fetus
- Rarity of fetal cells in exocervical samples for noninvasive prenatal diagnosis
- Original Articles – Neonates
- Effects of oral stimulation with breast milk in preterm infants oral feeding: a randomized clinical trial
- Perinatal factors associated with admission to neonatal intensive care unit following cesarean delivery in Kano, northern Nigeria
- Letter to the Editor
- Intrapartal fetal decapitation after shoulder dystocia – a forensically acceptable or unacceptable complication?
Articles in the same Issue
- Frontmatter
- WAPM Guideline
- The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine foundation
- Corner of Academy
- Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of the late preterm delivery regardless of the membrane status
- Original Articles – Obstetrics
- Comparison of cardiac morphology and function in small for gestational age fetuses and fetuses with late-onset fetal growth retardation
- Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study
- One year into the SARS-CoV-2 pandemic: perinatal outcome and data on the transmission of 116 pregnant women
- Adverse perinatal outcomes of chlamydia infections: an ongoing challenge
- Pregnancy outcomes with differences in grain consumption: a randomized controlled trial
- Who needs prenatal counselling with a pediatric surgeon? Experience from a large tertiary care university hospital
- To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study
- Placental characteristics of selective intrauterine growth restriction with changing patterns in umbilical artery Doppler flow in monochorionic diamniotic twins
- Association between cesarean section rate and maternal age in twin pregnancies
- Maternal and neonatal outcomes associated with delivery techniques for impacted fetal head at cesarean section: a systematic review and meta-analysis
- Experience with direct oral anticoagulants in pregnancy – a systematic review
- Nasal bone in fetal aneuploidy risk assessment: are they independent markers in the first and second trimesters?
- Effects of music on sleep quality and comfort levels of pregnant women
- Original Articles – Fetus
- Rarity of fetal cells in exocervical samples for noninvasive prenatal diagnosis
- Original Articles – Neonates
- Effects of oral stimulation with breast milk in preterm infants oral feeding: a randomized clinical trial
- Perinatal factors associated with admission to neonatal intensive care unit following cesarean delivery in Kano, northern Nigeria
- Letter to the Editor
- Intrapartal fetal decapitation after shoulder dystocia – a forensically acceptable or unacceptable complication?
