To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study
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Reetu Hooda
and
Samander Kaushik
Abstract
Objectives
i) To compare the placental human papilloma virus (HPV) deoxynucleic acid (DNA) status of preterm deliveries with full term deliveries and to identify high risk (HR) genotypes (HPV 16 and 18); and ii) To compare the perinatal outcomes of HPV positive with HPV negative pregnant women.
Methods
A case control study was carried out on 100 antenatal women with singleton live pregnancies admitted in labor ward of a tertiary care teaching hospital from April 2017 to March 2018. The two study groups were i) spontaneous preterm deliveries between 24 and 36 + 6 weeks (n=50) and ii) full term deliveries ≥37 weeks (n=50). The placental tissue was analysed for HPV DNA and HR HPV genotypes were detected by type specific primers. A comparative analysis of perinatal outcomes between HPV positive and negative women was done.
Results
An overall placental tissue HPV prevalence of 12% (12/100) was observed in study cohort which was not significantly different between preterm and full term deliveries (16 vs. 8%, p=0.218). HPV 16 was significantly associated with preterm births (p=0.04). Both HPV affected and non-affected women were comparable in terms of mode of delivery and neonatal outcomes. However, a statistically significant association of preterm neonatal intensive care admissions with HR HPV 16 genotype was observed (p=0.04).
Conclusions
Spontaneous preterm births can be attributed to placental HPV infection, specifically HR HPV 16 genotype. This association identifies a potentially preventable cause of prematurity and its associated complications, in wake of availability of an effective vaccine.
Acknowledgments
The authors acknowledge the patients who participated in the study.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The research has complied with all the relevant national regulations, institutional policies, and in accordance with the Helsinki declaration and has been approved by the Institutional Ethical Committee.
References
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- WAPM Guideline
- The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine foundation
- Corner of Academy
- Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of the late preterm delivery regardless of the membrane status
- Original Articles – Obstetrics
- Comparison of cardiac morphology and function in small for gestational age fetuses and fetuses with late-onset fetal growth retardation
- Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study
- One year into the SARS-CoV-2 pandemic: perinatal outcome and data on the transmission of 116 pregnant women
- Adverse perinatal outcomes of chlamydia infections: an ongoing challenge
- Pregnancy outcomes with differences in grain consumption: a randomized controlled trial
- Who needs prenatal counselling with a pediatric surgeon? Experience from a large tertiary care university hospital
- To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study
- Placental characteristics of selective intrauterine growth restriction with changing patterns in umbilical artery Doppler flow in monochorionic diamniotic twins
- Association between cesarean section rate and maternal age in twin pregnancies
- Maternal and neonatal outcomes associated with delivery techniques for impacted fetal head at cesarean section: a systematic review and meta-analysis
- Experience with direct oral anticoagulants in pregnancy – a systematic review
- Nasal bone in fetal aneuploidy risk assessment: are they independent markers in the first and second trimesters?
- Effects of music on sleep quality and comfort levels of pregnant women
- Original Articles – Fetus
- Rarity of fetal cells in exocervical samples for noninvasive prenatal diagnosis
- Original Articles – Neonates
- Effects of oral stimulation with breast milk in preterm infants oral feeding: a randomized clinical trial
- Perinatal factors associated with admission to neonatal intensive care unit following cesarean delivery in Kano, northern Nigeria
- Letter to the Editor
- Intrapartal fetal decapitation after shoulder dystocia – a forensically acceptable or unacceptable complication?
Articles in the same Issue
- Frontmatter
- WAPM Guideline
- The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine foundation
- Corner of Academy
- Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of the late preterm delivery regardless of the membrane status
- Original Articles – Obstetrics
- Comparison of cardiac morphology and function in small for gestational age fetuses and fetuses with late-onset fetal growth retardation
- Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study
- One year into the SARS-CoV-2 pandemic: perinatal outcome and data on the transmission of 116 pregnant women
- Adverse perinatal outcomes of chlamydia infections: an ongoing challenge
- Pregnancy outcomes with differences in grain consumption: a randomized controlled trial
- Who needs prenatal counselling with a pediatric surgeon? Experience from a large tertiary care university hospital
- To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study
- Placental characteristics of selective intrauterine growth restriction with changing patterns in umbilical artery Doppler flow in monochorionic diamniotic twins
- Association between cesarean section rate and maternal age in twin pregnancies
- Maternal and neonatal outcomes associated with delivery techniques for impacted fetal head at cesarean section: a systematic review and meta-analysis
- Experience with direct oral anticoagulants in pregnancy – a systematic review
- Nasal bone in fetal aneuploidy risk assessment: are they independent markers in the first and second trimesters?
- Effects of music on sleep quality and comfort levels of pregnant women
- Original Articles – Fetus
- Rarity of fetal cells in exocervical samples for noninvasive prenatal diagnosis
- Original Articles – Neonates
- Effects of oral stimulation with breast milk in preterm infants oral feeding: a randomized clinical trial
- Perinatal factors associated with admission to neonatal intensive care unit following cesarean delivery in Kano, northern Nigeria
- Letter to the Editor
- Intrapartal fetal decapitation after shoulder dystocia – a forensically acceptable or unacceptable complication?
