Startseite Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
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Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study

  • Emily K. Clennon ORCID logo EMAIL logo , Bharti Garg , Brian D. Duty und Aaron B. Caughey
Veröffentlicht/Copyright: 18. August 2020
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 49 Heft 1

Abstract

Objectives

Evaluate the association between urolithiasis during pregnancy and obstetric outcomes outside the context of urological intervention.

Methods

We conducted a retrospective cohort study of singleton, non-anomalous gestations delivered at 23–42 weeks in California from 2007 to 2011. Maternal outcomes (preterm delivery [early (<32 weeks) and late (<37 weeks)], preeclampsia, gestational diabetes, cesarean deliveries, urinary tract infection [UTI] at delivery, chorioamnionitis, endomyometritis, and maternal sepsis) and newborn outcomes (seizure, respiratory distress syndrome, hypoglycemia, jaundice, and neonatal abstinence syndrome [NAS]) were compared using χ2-tests and multivariable logistic regression.

Results

A total of 2,013,767 pregnancies met inclusion criteria, of which 5,734 (0.28%) were complicated by urolithiasis. Stone disease during pregnancy was associated with 30% greater odds of each early (aOR 1.30; 95% CI 1.19–1.43) and late (aOR 1.29; 95% CI 1.18–1.41) preterm delivery. Cesarean delivery, UTI at delivery, gestational hypertension, gestational diabetes, preeclampsia, and sepsis were all significantly positively associated with urolithiasis. Odds of NAS (aOR 2.11; 95% CI 1.27–3.51) and jaundice were significantly greater in the neonates of stone-forming patients (aOR 1.08; 95% CI 1.01–1.16).

Conclusions

Urolithiasis during pregnancy was associated with 30% greater odds of preterm delivery and increased risk of myriad metabolic, hypertensive, and infectious disorders of gestation. Neonates born to stone-forming patients were more than twice as likely to develop neonatal abstinence syndrome but did not have significantly greater odds of complications of prematurity.

Keywords: nephrolithiasis; obstetric; pregnancy; stone disease; urolithiasis
Corresponding author: Emily K. Clennon, MD, MPH, Oregon Health & Science University, Department of Urology, Portland, OR, USA, Phone: 217-369-5880, Fax: 503-494-2391, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: We obtained human subjects approval from the Oregon Health and Science University Institutional Review Board, the California Office of Statewide Health Planning and Development, and the California Committee for the Protection of Human Subjects.

  5. Disclosure: The views expressed in this article are the authors’ own and do not represent any official positions of Oregon Health and Science University.

References

1. Butler, EL, Cox, SM, Eberts, EG, Cunningham, FG. Symptomatic nephrolithiasis complicating pregnancy. Obstet Gynecol 2000;96:753–6. https://doi.org/10.1097/00006250-200011000-00020.Suche in Google Scholar

2. Lewis, DF, Robichaux, AG, Jaekle, RK, Marcum, NG, Stedman, CM. Urolithiasis in pregnancy: diagnosis, management, and pregnancy outcome. Obstet Gynecol Surv 2003;58:446–447. https://doi.org/10.1097/01.OGX.0000074323.48257.83.Suche in Google Scholar

3. Stothers, L, Lee, LM. Renal colic in pregnancy. J Urol 1992;148:1383–7. https://doi.org/10.1016/s0022-5347(17)36917-3.Suche in Google Scholar PubMed

4. Swartz, MA, Lydon-Rochelle, MT, Simon, D, Wright, JL, Porter, MP. Admission for nephrolithiasis in pregnancy and risk of adverse birth outcomes. Obstet Gynecol 2007;109:1099–104. https://doi.org/10.1097/01.aog.0000259941.90919.c0.Suche in Google Scholar

5. Rosenberg, E, Sergienko, R, Abu-Ghanem, S, Wiznitzer, A, Romanowsky, I, Neulander, EA, et al. Nephrolithiasis during pregnancy: characteristics, complications, and pregnancy outcome. World J Urol 2011;29:743–7. https://doi.org/10.1007/s00345-011-0719-7.Suche in Google Scholar PubMed

6. Tangren, JS, Powe, CE, Ecker, J, Bramham, K, Ankers, E, Karumanchi, SA, et al. Metabolic and hypertensive complications of pregnancy in women with nephrolithiasis. Clin J Am Soc Nephrol 2018;13:612–9. https://doi.org/10.2215/cjn.12171017.Suche in Google Scholar

7. Drescher, M, Blackwell, RH, Patel, PM, Kuo, PC, Turk, TMT, Baldea, KG. Antepartum nephrolithiasis and the risk of preterm delivery. Urolithiasis 2019;47:441–8. https://doi.org/10.1007/s00240-018-1085-3.Suche in Google Scholar PubMed

8. Sohlberg, EM, Brubaker, WD, Zhang, CA, Anderegg, LDL, Dallas, KB, Song, S, et al. Urinary stone disease in pregnancy: a claims based analysis of 1.4 million patients. J Urol 2020;203:957–61. https://doi.org/10.1097/ju.0000000000000657.Suche in Google Scholar PubMed

9. Lowry, PS, Jerde, TJ, Bjorling, DE, Maskel, JL, Nakada, SY. Obstruction alters the effect of prostaglandin estradiol (E2) on ureteral contractility. J Endourol 2005;19:183–7. https://doi.org/10.1089/end.2005.19.183.Suche in Google Scholar PubMed

10. Parulkar, BG, Hopkins, TB, Wollin, MR, Howard, PJJr, Lal, A. Renal colic during pregnancy: a case for conservative treatment. J Urol 1998;159:365–8. https://doi.org/10.1016/s0022-5347(01)63918-1.Suche in Google Scholar PubMed

11. Khoo, L, Anson, K, Patel, U. Success and short-term complication rates of percutaneous nephrostomy during pregnancy. J Vasc Interv Radiol 2004;15:1469–73. https://doi.org/10.1097/01.rvi.0000140639.57131.6d.Suche in Google Scholar PubMed

12. Cormier, CM, Canzoneri, BJ, Lewis, DF, Briery, C, Knoepp, L, Mailhes, JB. Urolithiasis in pregnancy: current diagnosis, treatment, and pregnancy complications. Obstet Gynecol Surv 2006;61:733–41. https://doi.org/10.1097/01.ogx.0000243773.05916.7a.Suche in Google Scholar PubMed

13. Semins, MJ, Trock, BJ, Brian, RM. The safety of ureteroscopy during pregnancy: a systematic review and meta-analysis. J Urol 2009;181:139–43. https://doi.org/10.1016/j.juro.2008.09.029.Suche in Google Scholar PubMed

14. Burgess, KL, Gettman, MT, Rangel, LJ, Krambeck, AE. Diagnosis of urolithiasis and rate of spontaneous passage during pregnancy. J Urol 2011;186:2280–4. https://doi.org/10.1016/j.juro.2011.07.103.Suche in Google Scholar PubMed

15. Song, Y, Fei, X, Song, Y. Diagnosis and operative intervention for problematic ureteral calculi during pregnancy. Int J Gynecol Obstet 2013;121:115–8. https://doi.org/10.1016/j.ijgo.2012.12.012.Suche in Google Scholar PubMed

16. Wang, Z, Xu, L, Su, Z, Yao, C, Chen, Z. Invasive management of proximal ureteral calculi during pregnancy. Urology 2014;83:745–9. https://doi.org/10.1016/j.urology.2013.11.031.Suche in Google Scholar PubMed

17. Venyo, AKG, Fatola, CO, Adegbite, D, Khan, AN. Nephrostomy in pregnancy a district general hospital experience over five years. J Biomed Graphics Comput 2015;5:1–10. https://doi.org/10.5430/jbgc.v5n1p1.Suche in Google Scholar

18. Stover, MW, Davis, JM. Opioids in pregnancy and neonatal abstinence syndrome. Semin Perinatol 2015;39:561–5. https://doi.org/10.1053/j.semperi.2015.08.013.Suche in Google Scholar PubMed PubMed Central

Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2020-0199).

Received: 2020-05-04
Accepted: 2020-07-30
Published Online: 2020-08-18
Published in Print: 2021-01-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Global approach of the cesarean section rates
  4. Review
  5. Cesarean section one hundred years 1920–2020: the Good, the Bad and the Ugly
  6. Original Articles – Obstetrics
  7. Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation
  8. Retrospective study of maternal and neonatal outcomes after induction compared to spontaneous start of labour in women with one previous birth in uncomplicated pregnancies ≥ 41+3
  9. Management of labor after external cephalic version
  10. Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth
  11. Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
  12. Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology
  13. Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
  14. Serum kallistatin level is decreased in women with preeclampsia
  15. An observational study to assess Italian obstetrics providers’ knowledge about preventive practices and diagnosis of congenital cytomegalovirus
  16. Predictive values of clinical parameters and biophysical and biochemical markers in the first trimester for the detection of small-for-gestational age fetuses
  17. Original Articles – Newborns
  18. Antenatal and perinatal outcomes of refugees in high income countries
  19. Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight
  20. Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial
  21. Erratum
  22. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
  23. Acknowledgment
  24. Acknowledgment
https://doi.org/10.1515/jpm-2020-0199
Schlagwörter für diesen Artikel
nephrolithiasis; obstetric; pregnancy; stone disease; urolithiasis

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Global approach of the cesarean section rates
  4. Review
  5. Cesarean section one hundred years 1920–2020: the Good, the Bad and the Ugly
  6. Original Articles – Obstetrics
  7. Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation
  8. Retrospective study of maternal and neonatal outcomes after induction compared to spontaneous start of labour in women with one previous birth in uncomplicated pregnancies ≥ 41+3
  9. Management of labor after external cephalic version
  10. Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth
  11. Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
  12. Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology
  13. Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
  14. Serum kallistatin level is decreased in women with preeclampsia
  15. An observational study to assess Italian obstetrics providers’ knowledge about preventive practices and diagnosis of congenital cytomegalovirus
  16. Predictive values of clinical parameters and biophysical and biochemical markers in the first trimester for the detection of small-for-gestational age fetuses
  17. Original Articles – Newborns
  18. Antenatal and perinatal outcomes of refugees in high income countries
  19. Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight
  20. Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial
  21. Erratum
  22. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
  23. Acknowledgment
  24. Acknowledgment
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