Startseite Serum kallistatin level is decreased in women with preeclampsia
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Serum kallistatin level is decreased in women with preeclampsia

  • Onur Güralp EMAIL logo , Nevin Tüten , Koray Gök , Kübra Hamzaoglu , Huri Bulut , Meike Schild-Suhren , Eduard Malik und Abdullah Tüten
Veröffentlicht/Copyright: 31. August 2020
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 49 Heft 1

Abstract

Objectives

To evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE).

Methods

The clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus.

Results

Mean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.

Conclusions

Serum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.

Keywords: early-onset preeclampsia; hypertension; kallikrein inhibitor; nitric-oxide; serpinA4
Corresponding author: Onur Güralp, MD, Senior Consultant, University Hospital of Obstetrics and Gynecology, Klinikum Oldenburg, AöR Carl von Ossietzky Oldenburg University, Rahel-Strauß-Str. 10, 26133, Oldenburg, Germany. Phone: 0049 441 403 2288, E-mail:

Acknowledgments

We would like to thank our beloved nurse Medine Eltutan from our pregnancy outpatient clinic for her kind support and dedication during the patient recruitment.

  1. Research funding: This study was financed by Istanbul Cerrahpasa University, Istanbul, Turkey, and Carl von Ossietzky University Oldenburg, University Hospital for Obstetrics and Gynecology in Klinikum Oldenburg AöR, Oldenburg, Germany.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study protocol was approved by the Ethics Committee of Istanbul Cerrahpasa University, School of Medicine and informed consent was obtained from all women participating our study. We have complied with the World Medical Association Declaration of Helsinki regarding ethical conduct of research involving human subjects and/or animals.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2020-0142).

Received: 2020-03-31
Accepted: 2020-07-30
Published Online: 2020-08-31
Published in Print: 2021-01-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Global approach of the cesarean section rates
  4. Review
  5. Cesarean section one hundred years 1920–2020: the Good, the Bad and the Ugly
  6. Original Articles – Obstetrics
  7. Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation
  8. Retrospective study of maternal and neonatal outcomes after induction compared to spontaneous start of labour in women with one previous birth in uncomplicated pregnancies ≥ 41+3
  9. Management of labor after external cephalic version
  10. Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth
  11. Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
  12. Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology
  13. Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
  14. Serum kallistatin level is decreased in women with preeclampsia
  15. An observational study to assess Italian obstetrics providers’ knowledge about preventive practices and diagnosis of congenital cytomegalovirus
  16. Predictive values of clinical parameters and biophysical and biochemical markers in the first trimester for the detection of small-for-gestational age fetuses
  17. Original Articles – Newborns
  18. Antenatal and perinatal outcomes of refugees in high income countries
  19. Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight
  20. Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial
  21. Erratum
  22. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
  23. Acknowledgment
  24. Acknowledgment
https://doi.org/10.1515/jpm-2020-0142
Schlagwörter für diesen Artikel
early-onset preeclampsia; hypertension; kallikrein inhibitor; nitric-oxide; serpinA4

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Global approach of the cesarean section rates
  4. Review
  5. Cesarean section one hundred years 1920–2020: the Good, the Bad and the Ugly
  6. Original Articles – Obstetrics
  7. Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation
  8. Retrospective study of maternal and neonatal outcomes after induction compared to spontaneous start of labour in women with one previous birth in uncomplicated pregnancies ≥ 41+3
  9. Management of labor after external cephalic version
  10. Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth
  11. Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
  12. Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology
  13. Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
  14. Serum kallistatin level is decreased in women with preeclampsia
  15. An observational study to assess Italian obstetrics providers’ knowledge about preventive practices and diagnosis of congenital cytomegalovirus
  16. Predictive values of clinical parameters and biophysical and biochemical markers in the first trimester for the detection of small-for-gestational age fetuses
  17. Original Articles – Newborns
  18. Antenatal and perinatal outcomes of refugees in high income countries
  19. Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight
  20. Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial
  21. Erratum
  22. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
  23. Acknowledgment
  24. Acknowledgment
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