Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
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Ahmed S. S. A. Rashwan
,
Mohamed el-sharkawy
Abstract
Objectives
To evaluate the effect of altering vaginal pH on induction of labor in full-term pregnancies using Misoprostol.
Methods
This randomized controlled trial was conducted at Kasralainy Hospital, Cairo University, Egypt and Algezeera Hospital, Egypt. A total of 218 healthy term primigravida pregnant women who were scheduled for pregnancy termination were recruited in the study. The included patients were divided into three groups; Group A: Those who received normal saline vaginal wash (0.9% NaCl), Group B: those who received alkaline vaginal wash (5% sodium bicarbonate) and Group C: those who received acidic vaginal wash (5% acetic acid). Patients received 25 μg of Misoprostol E1 (Vagiprost® Adwia Pharmaceuticals, Egypt) every 6 h for a maximum of 24 h (total of four potential doses).
Results
The ‘acid’ group participants took a mean time of 20.46 h to reach active stage of labor, followed by the ‘normal saline’ group with 21.45 h and the ‘alkaline’ group with 22.59 h. The difference between the groups was statistically significant, with a p-value of 0.013.
Conclusions
Douching the vagina with acidic solution seems to supplement the effect of Misoprostol on inducing labor in full-term pregnancies, as evidenced by having the shortest mean time needed to reach active stage of labor.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The study was conducted after getting approval from an Institutional Review Board (IRB). The study conforms to the provisions of the Declaration of Helsinki.
References
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Global approach of the cesarean section rates
- Review
- Cesarean section one hundred years 1920–2020: the Good, the Bad and the Ugly
- Original Articles – Obstetrics
- Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation
- Retrospective study of maternal and neonatal outcomes after induction compared to spontaneous start of labour in women with one previous birth in uncomplicated pregnancies ≥ 41+3
- Management of labor after external cephalic version
- Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth
- Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
- Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology
- Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
- Serum kallistatin level is decreased in women with preeclampsia
- An observational study to assess Italian obstetrics providers’ knowledge about preventive practices and diagnosis of congenital cytomegalovirus
- Predictive values of clinical parameters and biophysical and biochemical markers in the first trimester for the detection of small-for-gestational age fetuses
- Original Articles – Newborns
- Antenatal and perinatal outcomes of refugees in high income countries
- Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight
- Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial
- Erratum
- Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
- Acknowledgment
- Acknowledgment
Articles in the same Issue
- Frontmatter
- Editorial
- Global approach of the cesarean section rates
- Review
- Cesarean section one hundred years 1920–2020: the Good, the Bad and the Ugly
- Original Articles – Obstetrics
- Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation
- Retrospective study of maternal and neonatal outcomes after induction compared to spontaneous start of labour in women with one previous birth in uncomplicated pregnancies ≥ 41+3
- Management of labor after external cephalic version
- Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth
- Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial
- Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology
- Obstetric outcomes of pregnancy complicated by urolithiasis: a retrospective cohort study
- Serum kallistatin level is decreased in women with preeclampsia
- An observational study to assess Italian obstetrics providers’ knowledge about preventive practices and diagnosis of congenital cytomegalovirus
- Predictive values of clinical parameters and biophysical and biochemical markers in the first trimester for the detection of small-for-gestational age fetuses
- Original Articles – Newborns
- Antenatal and perinatal outcomes of refugees in high income countries
- Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight
- Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial
- Erratum
- Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
- Acknowledgment
- Acknowledgment
