Uterine artery Doppler pulsatility index at 11–38 weeks in ICSI pregnancies with egg donation
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Annalisa Inversetti
Abstract
Background:
Uterine artery Doppler pulsatility index (UtA-PI) may be different in pregnancies with egg donation (ICSI-ED) as compared to conceptions with autologous intra-cytoplasmatic sperm injection (autologous ICSI) and to spontaneous conceptions (SC).
Methods:
One hundred and ninety-four pregnant women with different modes of conception (MC) were prospectively evaluated: 53 ICSI-ED, 36 autologous ICSI and 105 SC. To evaluate the effects of different MC on PI, multivariable linear regression (MLR) models predicting UtA-PI were fitted after adjustment for maternal age, body mass index, race, parity, smoking status and gestational age.
Results:
In the first trimester, at MLR, autologous ICSI was not associated with a significantly different UtA-PI [estimate (EST) 0.01; 95% confidence interval (CI) −0.19, 0.2; P=0.9] when compared to SC. Conversely, MC by ICSI-ED was associated with lower first trimester UtA-PI (EST −0.32; CI −0.55, −0.08; P=0.01) when compared to SC. At MLR, MC by autologous ICSI and by ICSI-ED were not associated with significant differences in the second and third trimester UtA-PI when compared to SC.
Conclusion:
ICSI-ED conception presented lower UtA-PI when compared to SC at 11+0–13+6 weeks but not at later assessments. Correction of UtA-PI measurement specifying the origin of oocyte may be useful in first trimester screening.
Acknowledgments
We acknowledge physicians, biologists and midwifes in Prenatal Diagnosis and Infertility Units of San Raffaele Hospital for their voluntary cooperation, which made possible this non-funded research.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Review article
- The assessment of labor: a brief history
- Original articles – Obstetrics
- The combined exposure to intra-amniotic inflammation and neonatal respiratory distress syndrome increases the risk of intraventricular hemorrhage in preterm neonates
- Uterine artery Doppler pulsatility index at 11–38 weeks in ICSI pregnancies with egg donation
- Violence before pregnancy and the risk of violence during pregnancy
- Cancer during pregnancy – clinical characteristics, treatment outcomes and prognosis for mothers and infants
- The effect of attending a prenatal childbirth preparedness course on labor duration and outcomes
- Serum fibrinogen levels could be an index of successful use of balloon tamponade in postpartum hemorrhage
- Impact factors on cervical dilation rates in the first stage of labor
- Feasibility and acceptability of text messaging to support antenatal healthcare in Iraqi pregnant women: a pilot study
- Clinical characteristics and outcome of twin pregnancies complicated by single intrauterine death
- Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review
- The association between pre-pregnancy obesity and screening results of depression for all trimesters of pregnancy, postpartum and 1 year after birth: a cohort study
- Original articles – Fetus
- Causes of intrauterine fetal death are changing in recent years
- Original articles – Newborn
- Proactive approach at the limits of viability improves the short-term outcome of neonates born after 23 weeks’ gestation
- Letter to the Editor
- Exact days of gestation necessary for infants at borderline viability: reply to Proactive approach at the limits of viability improves the short-term outcome of neonates born after 23weeks’ gestation. P. Šimják, J. Smíšek, M. Koucký, T. Lamberská, R. Plavka and Z. Hájek. J Perinat Med 2017
