Cancer during pregnancy – clinical characteristics, treatment outcomes and prognosis for mothers and infants
-
Katarina Jeremic
,
Aleksandar Stefanovic
Abstract
Objective:
To assess which obstetrical characteristics and treatment improved outcomes and prognosis of pregnant women with malignancy.
Methods:
A prospective study, undertaken between 2005 and 2014, involving 35 pregnant women who were diagnosed with malignant tumors during pregnancy. Patients were followed-up for 1 year after delivery. The pregnancy course and outcome and parameters that could influence the condition of mother and fetus were evaluated.
Results:
Most malignancies were hematological, diagnosed in the second trimester and treated with combined therapy (surgery/adjuvant) after pregnancy. Most fetuses were in good state throughout pregnancy, but were delivered by caesarean section (CS) before term. Adjuvant therapy during pregnancy mostly caused transitory deterioration of fetal conditions. The majority of both mothers and infants were in a good state 12 months postpartum, although numerous mothers were still ill and on therapy. Surviving pregnancy and preventing tumors progression during pregnancy were the best predictors of mothers’ future condition (P=0.022). High birthweight and term delivery were the most important factors for good outcome of the infants (P=0.001).
Conclusions:
If the tumor is not progressing, pregnancy should be continued as long as possible to obtain adequate birthweight of the infant. Second trimester surgery is safe, while other therapies should preferably be applied after delivery.
Acknowledgment
This work was supported by research Grant No 41023 for period 2011–2015 issued by the Ministry of Science of the Republic of Serbia.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
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- Letter to the Editor
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Articles in the same Issue
- Frontmatter
- Review article
- The assessment of labor: a brief history
- Original articles – Obstetrics
- The combined exposure to intra-amniotic inflammation and neonatal respiratory distress syndrome increases the risk of intraventricular hemorrhage in preterm neonates
- Uterine artery Doppler pulsatility index at 11–38 weeks in ICSI pregnancies with egg donation
- Violence before pregnancy and the risk of violence during pregnancy
- Cancer during pregnancy – clinical characteristics, treatment outcomes and prognosis for mothers and infants
- The effect of attending a prenatal childbirth preparedness course on labor duration and outcomes
- Serum fibrinogen levels could be an index of successful use of balloon tamponade in postpartum hemorrhage
- Impact factors on cervical dilation rates in the first stage of labor
- Feasibility and acceptability of text messaging to support antenatal healthcare in Iraqi pregnant women: a pilot study
- Clinical characteristics and outcome of twin pregnancies complicated by single intrauterine death
- Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review
- The association between pre-pregnancy obesity and screening results of depression for all trimesters of pregnancy, postpartum and 1 year after birth: a cohort study
- Original articles – Fetus
- Causes of intrauterine fetal death are changing in recent years
- Original articles – Newborn
- Proactive approach at the limits of viability improves the short-term outcome of neonates born after 23 weeks’ gestation
- Letter to the Editor
- Exact days of gestation necessary for infants at borderline viability: reply to Proactive approach at the limits of viability improves the short-term outcome of neonates born after 23weeks’ gestation. P. Šimják, J. Smíšek, M. Koucký, T. Lamberská, R. Plavka and Z. Hájek. J Perinat Med 2017
