A comparison of referral patterns to the pediatric endocrine clinic before and after FDA approval of growth hormonefor idiopathic short stature
-
Andrea K. Goldyn
,
Zeina M. Nabhan
Abstract
Background: Short stature is a common reason for referral to the pediatric endocrine clinic. In 2003, the US Food and Drug Administration (FDA) approved the use of growth hormone (GH) for the treatment of children with idiopathic short stature (ISS).
Objective: To explore if this indication changed referrals for short stature (SS).
Design/Methods: A retrospective chart review of children seen for SS in the pediatric endocrine clinic between July 1998 and June 1999 (interval one, n=138) and July 2005–June 2006 (interval two, n=268) was performed. Variables collected included age, gender, height (h), and parental heights.
Results: Average height standard deviation score (HT-SDS) was –2.11±0.9 in interval one and –2.14±0.83 in interval two (p=ns). No differences in age, gender distribution, relationship between child and parental heights, the proportion of subjects started on GH for ISS or in the HT-SDS of those treated between the two intervals were identified. Nearly half of all children referred in each interval did not meet the technical criteria for short stature.
Conclusions: No differences in referral patterns for SS in our area following FDA approval of GH for ISS were identified. Although referrals appear unchanged, additional investigation of GH prescribing patterns before and after this new indication is needed. Continued education of primary care physicians and the general public regarding the definition of SS and the eligibility for GH therapy should be pursued.
©2011 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Publisher's Note
- Publisher's Note
- Editorial
- Sex steroid priming for growth hormone (GH) provocative tests: an endless debate with insufficient solution
- Not ready for prime time
- Commentary
- Sex hormone priming
- Pros of priming in the diagnosis of growth hormone deficiency
- Images in Pediatric Endokrinology
- Images in pediatric endocrinology: vitamin D deficiency rickets and other nutritional deficiencies in a 12-month-old infant
- Original Contributions
- The influence of an educational program on the HbA1c-level of adolescents with type 1 diabetes mellitus: a retrospective study
- Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents
- Hyperphosphatemic tumoral calcinosis: a 10-year follow-up
- Vitamin D deficiency and insulin resistance in obese African- American adolescents
- Evaluation of children with nutritional rickets
- The effects of delivery route and anesthesia type on early postnatal weight loss in newborns: the role of vasoactive hormones
- Abdominal obesity is associated with cardiovascular risk in Japanese children and adolescents
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- Severe hypercalcemia associated with Williams syndrome successfully treated with pamidronate infusion therapy
- The subtle signs of Wolfram (DIDMOAD) syndrome: not all juvenile diabetes is type 1 diabetes
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- A comparison of referral patterns to the pediatric endocrine clinic before and after FDA approval of growth hormonefor idiopathic short stature
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- Meetings Calendar
