The effects of delivery route and anesthesia type on early postnatal weight loss in newborns: the role of vasoactive hormones
-
Nurullah Okumus
,
Berrin Gunaydin
Abstract
Objective: To investigate the effects of delivery route and maternal anesthesia type and the roles of vasoactive hormones on early postnatal weight loss in term newborns.
Methods: Ninety-four term infants delivered vaginally (group 1, n=31), cesarean section (C/S) with general anesthesia (GA) (group 2, n=29), and C/S with epidural anesthesia (EA) (group 3, n=34) were included in this study. All infants were weighed at birth and on the second day of life and intravenous (IV) fluid infused to the mothers for the last 6 h prior to delivery was recorded. Serum electrolytes, osmolality, N-terminal proANP (NT-proANP), brain natriuretic peptide (BNP), aldosterone and plasma antidiuretic hormone (ADH) concentrations were measured at cord blood and on the second day of life.
Results: Our research showed that postnatal weight loss of infants was higher in C/S than vaginal deliveries (5.7% vs. 1.3%) (p<0.0001) and in EA group than GA group (6.8% vs. 4.3%) (p<0.0001). Postnatal weight losses were correlated with IV fluid volume infused to the mothers for the last 6 h prior to delivery (R=0.814, p=0.000) and with serum NT-proANP (R=0.418, p=0.000), BNP (R=0.454, p=0.000), and ADH (R=0.509, p=0.000) but not with aldosterone concentrations (p>0.05).
Conclusion: Large amounts of IV fluid given to the mothers who were applied EA prior to the delivery affect their offsprings’ postnatal weight loss via certain vasoactive hormones.
©2011 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Publisher's Note
- Publisher's Note
- Editorial
- Sex steroid priming for growth hormone (GH) provocative tests: an endless debate with insufficient solution
- Not ready for prime time
- Commentary
- Sex hormone priming
- Pros of priming in the diagnosis of growth hormone deficiency
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- Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents
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