Home The relationship of salivary and cord blood cortisol inpreterm infants
Article
Licensed
Unlicensed Requires Authentication

The relationship of salivary and cord blood cortisol inpreterm infants

  • I-Ching Chou , Han-Chung Lien , Hung-Chih Lin , Jachih J.C. Fu , Chia-Hung Kao , Chang-Hai Tsai , Pao-Hsuan Lin and Fuu-Jen Tsai EMAIL logo
Published/Copyright: March 16, 2011
Journal of Pediatric Endocrinology and Metabolism
From the journal Volume 24 Issue 1-2

Abstract

Recent studies reveal that salivary cortisol measurements accurately reflect blood cortisol levels in older children and adults; yet, the relationship between the two values in premature infants has not been established. This study explores the use of salivary cortisol as an accurate measure of adrenal steroid concentrations in premature infants to provide a reliable and less invasive tool for investigating hormonal stress response. Premature infants (n=51) were recruited, with saliva and blood collected immediately after birth, and cortisol levels measured by radioimmunoassay. A linear relationship emerged between cord plasma and salivary cortisol values in the 102 paired samples [(salivary cortisol)=0.546+0.192×(plasma cortisol), r=0.481 and p=0.0003]. Findings demonstrated that salivary and plasma cortisol levels were correlated in premature infants. This information will be useful in future studies that assess use of salivary cortisol to evaluate neonatal stress axis function.

Keywords: cortisol; preterm; saliva; stress
Corresponding author: Fuu-Jen Tsai, MD, PhD, Departments of Pediatrics and Medical Genetics, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung, Taiwan Phone: +886-4-22052121 Ext 2066, Fax: +886-4-22032798
Published Online: 2011-03-16
Published in Print: 2011-03-01

©2011 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. Publisher's Note
  2. Publisher's Note
  3. Editorial
  4. Sex steroid priming for growth hormone (GH) provocative tests: an endless debate with insufficient solution
  5. Not ready for prime time
  6. Commentary
  7. Sex hormone priming
  8. Pros of priming in the diagnosis of growth hormone deficiency
  9. Images in Pediatric Endokrinology
  10. Images in pediatric endocrinology: vitamin D deficiency rickets and other nutritional deficiencies in a 12-month-old infant
  11. Original Contributions
  12. The influence of an educational program on the HbA1c-level of adolescents with type 1 diabetes mellitus: a retrospective study
  13. Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents
  14. Hyperphosphatemic tumoral calcinosis: a 10-year follow-up
  15. Vitamin D deficiency and insulin resistance in obese African- American adolescents
  16. Evaluation of children with nutritional rickets
  17. The effects of delivery route and anesthesia type on early postnatal weight loss in newborns: the role of vasoactive hormones
  18. Abdominal obesity is associated with cardiovascular risk in Japanese children and adolescents
  19. PPAR-γ2 Pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity
  20. The relationship between pubertal gynecomastia, prostate specific antigen, free androgen index, SHBG and sex steroids
  21. Severe hypercalcemia associated with Williams syndrome successfully treated with pamidronate infusion therapy
  22. The subtle signs of Wolfram (DIDMOAD) syndrome: not all juvenile diabetes is type 1 diabetes
  23. The frequency of Hashimoto thyroiditis in children and the relationship between urinary iodine level and Hashimoto thyroiditis
  24. The relationship between serum phosphate levels with childhood obesity and insulin resistance
  25. The relationship of salivary and cord blood cortisol inpreterm infants
  26. A comparison of referral patterns to the pediatric endocrine clinic before and after FDA approval of growth hormonefor idiopathic short stature
  27. Benign transient hyperphosphatasemia in infants and children: a prospective cohort
  28. Carotid arterial stiffness in overweight and obese Indian children
  29. Association study in Taiwanese girls with precocious puberty
  30. Patient Report Letters
  31. A homozygous recurring mutation in WISP3 causing progressive pseudorheumatoid arthropathy
  32. Two pediatric patients with Von Hippel-Lindau disease type 2b: from patient to screening, from screening to patient
  33. Hot Topic
  34. Growth hormone and mortality: the anatomy of a global scare
  35. Meetings
  36. Meetings Calendar
https://doi.org/10.1515/jpem.2011.119
Keywords for this article
cortisol; preterm; saliva; stress

Articles in the same Issue

  1. Publisher's Note
  2. Publisher's Note
  3. Editorial
  4. Sex steroid priming for growth hormone (GH) provocative tests: an endless debate with insufficient solution
  5. Not ready for prime time
  6. Commentary
  7. Sex hormone priming
  8. Pros of priming in the diagnosis of growth hormone deficiency
  9. Images in Pediatric Endokrinology
  10. Images in pediatric endocrinology: vitamin D deficiency rickets and other nutritional deficiencies in a 12-month-old infant
  11. Original Contributions
  12. The influence of an educational program on the HbA1c-level of adolescents with type 1 diabetes mellitus: a retrospective study
  13. Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents
  14. Hyperphosphatemic tumoral calcinosis: a 10-year follow-up
  15. Vitamin D deficiency and insulin resistance in obese African- American adolescents
  16. Evaluation of children with nutritional rickets
  17. The effects of delivery route and anesthesia type on early postnatal weight loss in newborns: the role of vasoactive hormones
  18. Abdominal obesity is associated with cardiovascular risk in Japanese children and adolescents
  19. PPAR-γ2 Pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity
  20. The relationship between pubertal gynecomastia, prostate specific antigen, free androgen index, SHBG and sex steroids
  21. Severe hypercalcemia associated with Williams syndrome successfully treated with pamidronate infusion therapy
  22. The subtle signs of Wolfram (DIDMOAD) syndrome: not all juvenile diabetes is type 1 diabetes
  23. The frequency of Hashimoto thyroiditis in children and the relationship between urinary iodine level and Hashimoto thyroiditis
  24. The relationship between serum phosphate levels with childhood obesity and insulin resistance
  25. The relationship of salivary and cord blood cortisol inpreterm infants
  26. A comparison of referral patterns to the pediatric endocrine clinic before and after FDA approval of growth hormonefor idiopathic short stature
  27. Benign transient hyperphosphatasemia in infants and children: a prospective cohort
  28. Carotid arterial stiffness in overweight and obese Indian children
  29. Association study in Taiwanese girls with precocious puberty
  30. Patient Report Letters
  31. A homozygous recurring mutation in WISP3 causing progressive pseudorheumatoid arthropathy
  32. Two pediatric patients with Von Hippel-Lindau disease type 2b: from patient to screening, from screening to patient
  33. Hot Topic
  34. Growth hormone and mortality: the anatomy of a global scare
  35. Meetings
  36. Meetings Calendar
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 15.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/jpem.2011.119/html
Scroll to top button