Bone Maturation in 1788 Children and Adolescents with Diabetes Mellitus Type 1
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Axel Dost
ABSTRACT
Diabetes mellitus type 1 might interfere with pubertal development. Particularly, longterm metabolic control and intensity of insulin treatment have been reported to contribute to a delay in pubertal onset. Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes. Bone age was retarded by -0.27 ± 1.1 years in the whole group, but particularly in the adolescents at the end of puberty (>16 years; -0.76±1.29y). Bone age delay was more pronounced in boys, and in children with longterm median HbA1c levels of 7.5 – 9.0%. No associations were found with current HbA1c levels or the intensity of insulin treatment. Bone age determinations in diabetic children should only be performed when clinical signs of impaired somatic development are present. In addition, the potential influence of diabetes on bone development needs to be considered in the interpretation of carpograms.
© Freund Publishing House Ltd.
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- Mass Ascites in Mulibrey Nanism
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- Bone Maturation in 1788 Children and Adolescents with Diabetes Mellitus Type 1
- Serum Thyroid Hormone Levels in Preterm Infants Born before 33 Weeks of Gestation and Association of Transient Hypothyroxinemia with Postnatal Characteristics
- Birth Length is a Predictor of Adiponectin Levels in Japanese Young Children
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- Benign Transient Hyperphosphatasemia of Infancy. A Common Benign Scenario, a Big Concern for a Pediatrician
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