Growth Hormone, Insulin Like Growth Factor-1, and Insulin-like Growth Factor-Binding Protein-3 Levels in the Neonatal Period: A Preliminary Study
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Selim Kurtoğlu
ABSTRACT
Background: Growth hormone (GH), insulin-like growth factor-1 (IGF-1), and IGF-binding protein-3 (IGFBP-3) are used in the neonatal period for evaluation of diseases such as GH deficiency, intrauterine growth restriction, and hypoglycemia. However, GH level has been reported as a single value during the neonatal period. In this study, we attempted to determine the changes of GH, IGF-1, and IGFBP-3 in the neonatal period for each week.
Methods: One hundred and two appropriate-for-gestational age (AGA) term neonates who did not have any diseases that would interfere with GH-IGF axis were included in this cross-sectional study. Blood samples were collected and serum GH, IGF-1 and IGFBP-3 levels were measured by immunoradiometric analysis (IRMA) and weekly values were obtained for the first postnatal four weeks. Results: We showed that GH level [median (1st-3rd quartile)] decreases from the first to the fourth postnatal week [25.1 (18.5-37.4); 17.2 (13.2-22.8); 17.6 (12.2-20.2); 14.4 (6.60-19.8) ng/mL, respectively)], IGF-1 and IGFBP-3 levels [median (1st-3rd quartile)] increase [41.7 (18.0-70.0); 55.9 (39.0-103); 53.0 (40.0-97.7); 71.7 (44.3-137) and 1852 (1597-2451); 2430 (1645-2838); 2841 (2280-3675); 3018 (2151-4189) ng/mL, respectively)].
Conclusions: GH, IGF-1 and IGFBP-3 values can be evaluated for each week separately instead of for the entire neonatal period.
© Freund Publishing House Ltd.
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- The Soy That Surrounds Us: An Endless Debate
- Soy as an Endocrine Disruptor: Cause for Caution?
- Mass Ascites in Mulibrey Nanism
- Delayed Gastric Emptying in Patients with Prader Willi Syndrome
- Age and Sex Differences in Fat Distribution in Non-Obese Japanese Children
- Premature Thelarche in Taiwanese Girls
- Growth Hormone, Insulin Like Growth Factor-1, and Insulin-like Growth Factor-Binding Protein-3 Levels in the Neonatal Period: A Preliminary Study
- Bone Maturation in 1788 Children and Adolescents with Diabetes Mellitus Type 1
- Serum Thyroid Hormone Levels in Preterm Infants Born before 33 Weeks of Gestation and Association of Transient Hypothyroxinemia with Postnatal Characteristics
- Birth Length is a Predictor of Adiponectin Levels in Japanese Young Children
- Genotype-Phenotype Correlation in CAH Patients with Severe CYP21A2 Point Mutations in the Republic of Macedonia
- Benign Transient Hyperphosphatasemia of Infancy. A Common Benign Scenario, a Big Concern for a Pediatrician
- Scarcity Despite Wealth: Osteopetrorickets
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- Insulin Resistance and the Metabolic Syndrome in Obese Children Referred to an Obesity Center
- Severe Dietary Protein Sensitivity and Hyperinsulinemic Hypoglycemia in a Patient with Heterozygous Mutation in HADH Gene
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