Investigation of Acquired Von Willebrand Syndrome in Children with Hypothyroidism: Reversal after Treatment with Thyroxine
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Özgür Olukman
ABSTRACT
Background: Acquired von Willebrand Syndrome (AvWS) is a rare bleeding disorder associated with various underlying conditions. Many case reports have been published so far on bleeding tendency in hypothyroidism resembling AvWS.
Objective: This study was designed to define the relationship between hypothyroidism and AvWS and to investigate the effects of L-thyroxine treatment.
Subjects: Twenty four hypothyroid patients were included in the study. Nineteen patients were evaluated during treatment, 5 patients were evaluated before hormone replacement.
Methods: Complete coagulation screening tests including levels of von Willebrand Factor antigen (vWF:Ag) and functional activity (vWF:RCo) were measured by thrombocyte aggregometer.
Results: We demonstrated low vWF:Ag and vWF:RCo in 13 patients. Two of the 13 patients were diagnosed as AvWS, while another 2 patients were diagnosed as hereditary vWD Type 1. The remaining patients are still being followed-up.
Conclusion: We would like to attract the attention of paediatricians to the possibility of bleeding due to decreased activity of vWF in hypothyroid children.
© Freund Publishing House Ltd.
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- Soy as an Endocrine Disruptor: Cause for Caution?
- Mass Ascites in Mulibrey Nanism
- Delayed Gastric Emptying in Patients with Prader Willi Syndrome
- Age and Sex Differences in Fat Distribution in Non-Obese Japanese Children
- Premature Thelarche in Taiwanese Girls
- Growth Hormone, Insulin Like Growth Factor-1, and Insulin-like Growth Factor-Binding Protein-3 Levels in the Neonatal Period: A Preliminary Study
- Bone Maturation in 1788 Children and Adolescents with Diabetes Mellitus Type 1
- Serum Thyroid Hormone Levels in Preterm Infants Born before 33 Weeks of Gestation and Association of Transient Hypothyroxinemia with Postnatal Characteristics
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