Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
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Mehmet Akif Büyükavcı
und
Ismail Dundar
Abstract
Objectives
Congenital hypothyroidism (CH) is still one of the most common causes of preventable cognitive impairment in children, and its early detection and treatment prevent irreversible neurodevelopmental delay. Depending on the underlying cause, cases with CH may be transient or permanent. This study aimed to compare the developmental evaluation results of transient and permanent CH patients and to reveal any differences.
Methods
A total of 118 patients with CH, who were followed up jointly in pediatric endocrinology and developmental pediatrics clinics, were included. The patients’ progress was evaluated per the International Guide for Monitoring Child Development (GMCD).
Results
Of the cases, 52 (44.1%) were female, and 66 (55.9%) were male. While 20 (16.9%) cases were diagnosed with permanent CH, 98 (83.1%) were diagnosed with transient CH. According to the results of the developmental evaluation made with GMCD, the development of 101 (85.6%) children was compatible with their age, while 17 (14.4%) children had delays in at least one developmental area. All 17 patients had a delay in expressive language. Developmental delay was detected in 13 (13.3%) of those with transient CH and 4 (20%) with permanent CH.
Conclusions
There is difficulty in expressive language in all cases of CH with developmental delay. No significant difference was found between the developmental evaluations of permanent and transient CH cases. The results revealed the importance of developmental follow-up, early diagnosis and interventions in those children. GMCD is thought to be an important guide to help monitoring the development of patients with CH.
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Research funding: None declared.
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Author contributions: Surgical and Medical Practices: MAB, İD. Concept: MAB, İD. Design: MAB, İD. Data Collection or Processing: MAB, İD. Analysis or Interpretation: MAB, İD. Literature Search: MAB, İD. Writing: MAB, İD. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was not obtained as it was a retrospective study.
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Ethical approval: The study was approved by the Institutional Ethics Committee of Malatya Training and Research Hospital (document number: 23536505-604.02).
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Peer-review: Externally and internally peer-reviewed.
References
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- Approach to nutritional rickets
- Subclinical hyperthyroidism in children
- Original Articles
- Can thyroid elastography with ultrasound be used to stage children with Hashimoto’s thyroiditis?
- Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism
- Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
- Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes
- Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
- The WHO-5 well-being questionnaire in type 1 diabetes: screening for depression in pediatric and young adult subjects
- Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without autoimmune thyroiditis
- Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty
- Case Reports
- ALG11-CDG: novel variant and review of the literature
- Betamethasone cream to treat diapers rash causing Cushing syndrome
- Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome – neuro-endocrine tumours (ROHHAD-NET): case series and learning points
- Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability
- Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1
Artikel in diesem Heft
- Frontmatter
- Reviews
- Approach to nutritional rickets
- Subclinical hyperthyroidism in children
- Original Articles
- Can thyroid elastography with ultrasound be used to stage children with Hashimoto’s thyroiditis?
- Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism
- Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
- Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes
- Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
- The WHO-5 well-being questionnaire in type 1 diabetes: screening for depression in pediatric and young adult subjects
- Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without autoimmune thyroiditis
- Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty
- Case Reports
- ALG11-CDG: novel variant and review of the literature
- Betamethasone cream to treat diapers rash causing Cushing syndrome
- Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome – neuro-endocrine tumours (ROHHAD-NET): case series and learning points
- Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability
- Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1
