Can thyroid elastography with ultrasound be used to stage children with Hashimoto’s thyroiditis?
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Serkan Bilge Koca
and
Turgut Seber
Abstract
Objectives
We aimed to evaluate the stiffness of the thyroid parenchyma with Shear wave elastography (SWE) in children with Hashimoto’s thyroiditis (HT) and healthy controls.
Methods
A total of 130 children with HT and 46 healthy controls were included in this study. The clinical and laboratory characteristics of the groups, thyroiditis stages in thyroid ultrasonography, and SWE scores which was obtained as kilopascal (kPa), were analysed.
Results
We observed that SWE scores were significantly higher in children with HT compared to healthy controls, and SWE scores increased significantly in HT group, as the thyroiditis stage increased (p<0.001). Median, 1st (Q1) and 3rd (Q3) quartiles of SWE scores were as follows; healthy control: 7.4 kPa (6–10.6), stage 1 HT: 9.6 kPa (7.4–11.2), stage 2 HT: 15.2 kPa (10.8–19.9), stage 3 HT: 17.9 kPa (13.7–25.8), (p<0.001). Children with HT were divided into subgroups according to serum TSH and free T4 levels as euthyroid (103; 79.2% of children), euthyroid but subclinical TSH elevation (7; 5.4% of children), hypothyroidism (11; 8.5% of children) and hyperthyroidism (9; 6.9% of children). The SWE scores were significantly higher in children with hypothyroidism with HT compared to healthy controls 17.9 kPa (13.6–27.5) vs. 7.4 kPa (6–10.6), and in euthyroid children with HT compared to healthy controls 11.5 kPa (9.2–15.6) vs. 7.4 kPa (6–10.6), (p=0.006 and p<0.001, respectively).
Conclusions
The SWE scores increase as the thyroiditis stage increases in children with HT. There was no significant difference in SWE scores between stage 2 and stage 3 thyroiditis.
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Research funding: The authors did not receive any financial support from any public or private source. The authors have no financial or proprietary interest in a product, method, or material described here.
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Author contribution: Serkan Bilge Koca: study design, literature research, statistics, writing and editing the article. Turgut Seber: study design, writing and editing the article. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Conflict of interest: The authors declare that they have no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The study was organized in accordance with the ethical standards settled by the Ethics Committee of Health Sciences University Kayseri City Hospital.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Approach to nutritional rickets
- Subclinical hyperthyroidism in children
- Original Articles
- Can thyroid elastography with ultrasound be used to stage children with Hashimoto’s thyroiditis?
- Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism
- Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
- Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes
- Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
- The WHO-5 well-being questionnaire in type 1 diabetes: screening for depression in pediatric and young adult subjects
- Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without autoimmune thyroiditis
- Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty
- Case Reports
- ALG11-CDG: novel variant and review of the literature
- Betamethasone cream to treat diapers rash causing Cushing syndrome
- Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome – neuro-endocrine tumours (ROHHAD-NET): case series and learning points
- Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability
- Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1
Articles in the same Issue
- Frontmatter
- Reviews
- Approach to nutritional rickets
- Subclinical hyperthyroidism in children
- Original Articles
- Can thyroid elastography with ultrasound be used to stage children with Hashimoto’s thyroiditis?
- Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism
- Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
- Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes
- Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
- The WHO-5 well-being questionnaire in type 1 diabetes: screening for depression in pediatric and young adult subjects
- Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without autoimmune thyroiditis
- Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty
- Case Reports
- ALG11-CDG: novel variant and review of the literature
- Betamethasone cream to treat diapers rash causing Cushing syndrome
- Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome – neuro-endocrine tumours (ROHHAD-NET): case series and learning points
- Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability
- Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1
