Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1

Joy Cui; Kelsee Halpin; Emily Paprocki

doi:10.1515/jpem-2022-0294

Article

Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1

Joy Cui , Kelsee Halpin and Emily Paprocki

Published/Copyright: November 24, 2022

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From the journal Journal of Pediatric Endocrinology and Metabolism Volume 36 Issue 4

Abstract

Objectives

Classic treatment for syndrome of inappropriate antidiuretic hormone (SIADH) is fluid restriction. However, this is not ideal for infants who need large fluid volumes to ensure adequate caloric intake for growth. The use of urea has not been thoroughly studied in children.

Case presentation

This infant had SIADH complicated by poor growth, solitary central incisor, and NF1. Following failed attempts to correct hyponatremia with fluid restriction and other therapeutics, urea normalized sodium levels and allowed liberalization of formula volumes, which resulted in improved weight gain.

Conclusions

Urea is a safe, cost-effective, long-term treatment for SIADH in infants who are unable to fluid restrict due to caloric goals.

Keywords: SIADH; solitary central incisor; urea

Corresponding author: Emily Paprocki, DO, Division of Endocrinology, Children’s Mercy Kansas City, 3101 Broadway Blvd. Suite 900 Kansas City, MO 64111, USA; and School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA, Phone: 816 960 8892, E-mail: epaprocki@cmh.edu

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent obtained.
Ethical approval: Not applicable.

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Received: 2022-06-10

Accepted: 2022-10-28

Published Online: 2022-11-24

Published in Print: 2023-04-25

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Articles in the same Issue

https://doi.org/10.1515/jpem-2022-0294

Keywords for this article

SIADH; solitary central incisor; urea