Giant plurihormonal pituitary adenoma in a child – case study
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Elżbieta Moszczyńska
,
Wiesława Grajkowska
,
Maria Maksymowicz
,
Joanna Malicka
,
Mieczysław Szalecki
und
Monika Prokop-Piotrkowska
Abstract
Objectives
To describe the case of a 12-year-old girl with a rare plurihormonal pituitary macroadenoma secreting prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), and alpha subunit (α-SU).
Case presentation
The patient experienced recurrent headaches and progressing loss of vision in one eye. During the examination, abnormalities such as tall stature, coarse facial features, enlarged feet and hands, tachycardia, hand tremor, hyperhidrosis, galactorrhea, and goiter were observed. Head magnetic resonance imaging (MRI) revealed a solid tumor in the anterior and middle cranial fossa, measuring 80 × 50 × 55 mm. A stereotactic biopsy revealed plurihormonal Pit-1 positive pituitary adenoma secreting PRL, GH, and TSH. A pituitary hyperfunction with PRL, GH, TSH, and α-SU excess was diagnosed. The patient was successfully treated pharmacologically with dopamine agonists and somatostatin analogue, and a decrease of tumor volume (30%) was achieved.
Conclusions
When neurosurgery is not possible, long-term pharmacological treatment of plurihormonal pituitary macroadenoma can be a safe and relatively effective alternative.
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Research funding: None declared.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Competing interests: The authors declare no conflict of interests.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: We hereby state that the subject and her parent gave their written informed consent to publish their cases.
References
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
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- Original Articles
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- The effect of GnRH stimulation on AMH regulation in central precocious puberty and isolated premature thelarche
- Association of the apoptotic marker APO1/Fas with children’s predisposing factors for metabolic syndrome and with mean platelet volume
- Serum adiponectin, body adiposity and metabolic parameters in obese Egyptian children with Down syndrome
- Urinary iodine and thyroglobulin are useful markers in infants suspected of congenital hypothyroidism based on newborn screening
- Comparison of plasmapheresis with medical apheresis in terms of efficacy and cost in the acute treatment of hypertriglyceridemia in children with lipoprotein lipase deficiency
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