Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns
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Penelope D. Manta-Vogli
Abstract
Objectives
Medium-chain (MCA) and long-chain acylcarnitine (LCA) blood concentrations play a significant role in the fatty acid (FA) oxidation process, especially during the first days of life. Identification of their abnormal concentrations, via expanded newborn screening, can lead to the diagnosis of FA oxidation disorders. This study aimed to demonstrate MCA and LCA concentrations in Dried Blood Spots (DBS) of full-term breastfed infants, in relation to their birth weight (BW) perinatally.
Methods
Breastfed full-term infants (n = 12,000, 6,000 males, 6,000 females) with BW 2,000–3,999 g were divided into four equal groups: Group A, 2,000–2,499 g, B 2,500–2,999 g, C 3,000–3,499 g, and D 3,500–3,999 g. Samples were collected as DBS and acylcarnitines were determined via a liquid chromatography tandem mass spectrometry method.
Results
MCA and LCA blood concentrations were determined significantly lower in group A (low birth weight infants) in both sexes. Infants with BW > 3,500 g (group D), were characterized by lower levels of C10, C10:1, C14, C14:1 acylcarnitines and higher levels of C16 and C18:1 acylcarnitines, as compared to the other groups of this study.
Conclusions
Concentration patterns in full-term breastfed newborns in relation to sex and mainly BW found in this study could be very helpful for neonatologists, especially for newborns of group A.
Acknowledgments
Not applicable.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: Not applicable.
Employment or leadership: None declared.
Honorarium: None declared.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns
- Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator
- Short Communication
- Transient neonatal hyperinsulinism: early predictors of duration
- Case Reports
- An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes
- Different clinical entities of the same mutation: a case report of three sisters with Wolfram syndrome and efficacy of dipeptidyl peptidase-4 inhibitor therapy
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Artikel in diesem Heft
- Frontmatter
- Original Articles
- Clinical characteristics and treatment patterns with histrelin acetate subcutaneous implants vs. leuprolide injections in children with precocious puberty: a real-world study using a US claims database
- High serum neurotensin level in obese adolescents is not associated with metabolic parameters, hyperphagia or food preference
- Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus
- Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto’s thyroiditis: a single-center experience
- Evaluation of children with type 1 diabetes mellitus in terms of overweight/obesity in tertiary care hospital
- Association between anthropometric measures and insulin resistance in Brazilian adolescents: data from the national study of cardiovascular risk factors in adolescents – ERICA
- Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche
- Molecular and clinical findings of Turkish patients with hereditary fructose intolerance
- Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns
- Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator
- Short Communication
- Transient neonatal hyperinsulinism: early predictors of duration
- Case Reports
- An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes
- Different clinical entities of the same mutation: a case report of three sisters with Wolfram syndrome and efficacy of dipeptidyl peptidase-4 inhibitor therapy
- Short report: craniosynostosis, a late complication of nutritional rickets
- Childhood obesity as a safeguarding issue: positive experiences with the “new home” environment as a treatment for weight management
