High serum neurotensin level in obese adolescents is not associated with metabolic parameters, hyperphagia or food preference
-
Gülten Cingöz
,
Gonca Özyurt
,
Hamide Uzun
,
Özlem Gürsoy Doruk
,
Tuncay Küme
,
Bumin Nuri Dündar
and
Gönül Çatlı
Abstract
Objectives
Obesity is often the result of a high-calorie and unbalanced diet for a long time and can sometimes be associated with hyperphagia and eating disorders. Neurotensin (NT) is an anorexigenic peptide, which is secreted from the central nervous system and intestines, and increases intestinal fat absorption. In the literature, conflicting results regarding serum NT level in obesity and the relation of NT with metabolic parameters were reported. Besides, there is no data regarding the relation of NT with eating disorders or food preference in obese individuals. We aimed to evaluate the relation of serum NT level with metabolic parameters, hyperphagia, binge eating disorder (BED) and food preference in obese adolescents.
Methods
The study included 65 obese adolescents and 65 healthy controls. Anthropometric measurements, biochemical analyzes and body fat analyzes were performed in all cases. Hyperphagia score, presence of BED and three-day food intake records were also evaluated.
Results
NT level was significantly higher in obese adolescents than in controls and it was not associated with metabolic parameters, hyperphagia or food preference. In the obese group, NT level was not significantly different according to the presence of BED.
Conclusions
Serum NT level is high in obese adolescents; however, it is not associated with metabolic parameters, hyperphagia, BED or food preference.
Funding source: Scientific Research Project of Izmir Katip Celebi University, Faculty of Medicine, Izmir
Award Identifier / Grant number: 194
Research funding: Yes, We received financial support that is Scientific Research Project of Izmir Katip Celebi University, Faculty of Medicine, Izmir Projesi/award number: 194 for the article.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission. Description information for each author: G.C. performed anthropometric measurements and filled out case report forms, G.O. diagnosed patients with binge eating disorders, G.Ç. and A.A participated in the planning of the work and supervised it, conducted the analysis of the SPSS, prepared the manuscript and designed the tables. H.U. conducted bioelectric impedance analysis. T. K. and Ö.G.Ç. measured serum neurotensin levels using the ELISA method, and B. N. D assisted in interpreting the results and worked on the manuscript. All authors discussed the results and commented on the article.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.
Disclosure summary: The authors have nothing to disclose. There were no grants or fellowships supporting the writing of the paper.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Articles
- Clinical characteristics and treatment patterns with histrelin acetate subcutaneous implants vs. leuprolide injections in children with precocious puberty: a real-world study using a US claims database
- High serum neurotensin level in obese adolescents is not associated with metabolic parameters, hyperphagia or food preference
- Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus
- Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto’s thyroiditis: a single-center experience
- Evaluation of children with type 1 diabetes mellitus in terms of overweight/obesity in tertiary care hospital
- Association between anthropometric measures and insulin resistance in Brazilian adolescents: data from the national study of cardiovascular risk factors in adolescents – ERICA
- Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche
- Molecular and clinical findings of Turkish patients with hereditary fructose intolerance
- Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns
- Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator
- Short Communication
- Transient neonatal hyperinsulinism: early predictors of duration
- Case Reports
- An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes
- Different clinical entities of the same mutation: a case report of three sisters with Wolfram syndrome and efficacy of dipeptidyl peptidase-4 inhibitor therapy
- Short report: craniosynostosis, a late complication of nutritional rickets
- Childhood obesity as a safeguarding issue: positive experiences with the “new home” environment as a treatment for weight management
Articles in the same Issue
- Frontmatter
- Original Articles
- Clinical characteristics and treatment patterns with histrelin acetate subcutaneous implants vs. leuprolide injections in children with precocious puberty: a real-world study using a US claims database
- High serum neurotensin level in obese adolescents is not associated with metabolic parameters, hyperphagia or food preference
- Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus
- Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto’s thyroiditis: a single-center experience
- Evaluation of children with type 1 diabetes mellitus in terms of overweight/obesity in tertiary care hospital
- Association between anthropometric measures and insulin resistance in Brazilian adolescents: data from the national study of cardiovascular risk factors in adolescents – ERICA
- Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche
- Molecular and clinical findings of Turkish patients with hereditary fructose intolerance
- Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns
- Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator
- Short Communication
- Transient neonatal hyperinsulinism: early predictors of duration
- Case Reports
- An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes
- Different clinical entities of the same mutation: a case report of three sisters with Wolfram syndrome and efficacy of dipeptidyl peptidase-4 inhibitor therapy
- Short report: craniosynostosis, a late complication of nutritional rickets
- Childhood obesity as a safeguarding issue: positive experiences with the “new home” environment as a treatment for weight management
