Association between anthropometric measures and insulin resistance in Brazilian adolescents: data from the national study of cardiovascular risk factors in adolescents – ERICA

Daiane Cristina Pazin; Sandro Silva da Matta; José Rocha Faria-Neto; Katia Vergetti Bloch

doi:10.1515/jpem-2021-0191

Article

Association between anthropometric measures and insulin resistance in Brazilian adolescents: data from the national study of cardiovascular risk factors in adolescents – ERICA

Daiane Cristina Pazin , Sandro Silva da Matta , José Rocha Faria-Neto and Katia Vergetti Bloch

Published/Copyright: June 28, 2021

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From the journal Journal of Pediatric Endocrinology and Metabolism Volume 34 Issue 8

Abstract

Objectives

To evaluate anthropometric measures (AM) and insulin resistance (IR) association in adolescents aged 12–17 years and investigates how body mass index (BMI) interrelates with specific indicators of fat distribution in this association.

Methods

This analysis is from the Study of Cardiovascular Risks in Adolescents (ERICA) study, a national, cross-sectional study. AM was categorized by quartiles, and their means and 95% confidence intervals (95% CI) were estimated. The prevalence of IR was estimated for each AM according to the quartiles. The associations between AM and homeostatic model assessment of insulin resistance (HOMA-IR) levels were analyzed using Poisson models.

Results

37,892 adolescents were included. IR prevalence tended to increase as quartiles increased for each AM. The association of BMI with IR persisted with the adjustment for others AM. The greatest reduction in the association’s strength was achieved with the adjustment by the waist circumference (WC) and the waist-to-height ratio (WHtR). Most other AM were also associated with IR.

Conclusion

AM has a positive association with the prevalence of IR, and the joint effect of BMI and central adiposity measures should be considered in cardiometabolic risk evaluation in adolescents.

Keywords: adolescent; anthropometric measures; body mass index; cross-sectional studies; insulin resistance; public health

Corresponding author: Daiane Cristina Pazin, School of Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155, Curitiba, PR, Brasil, E-mail: daiane.pazin@pucpr.br

Funding source: Brazilian Ministry of Health

Acknowledgments

The authors appreciate the efforts of the research team members and participants. BLOCH KV was in the Central Coordination of the Study of Cardiovascular Risk in Adolescents – ERICA. She did the statistical analysis of this research. PAZIN DC and DA MATTA SS were involved with the whole execution of this article: literature review, data analysis, and article production. The final review, approval, and general supervision were conducted for FARIA-NETO JR and BLOCH KV.

Research funding: The Study of Cardiovascular Risk in Adolescents – ERICA – was supported by the Brazilian Ministry of Health.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: The authors declare that they have no competing interests.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2021-0191).

Received: 2021-03-16

Accepted: 2021-05-31

Published Online: 2021-06-28

Published in Print: 2021-08-26

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Keywords for this article

adolescent; anthropometric measures; body mass index; cross-sectional studies; insulin resistance; public health