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Delivery factors and neonatal thyroid hormone levels: a systematic review

  • Fahimeh Ramezani Tehrani ORCID logo und Sima Nazarpour ORCID logo EMAIL logo
Veröffentlicht/Copyright: 22. April 2021
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 34 Heft 7

Abstract

Postnatal thyroid hormone changes enable the neonate to be adapted for postnatal life. Several factors can affect this adaption. In this review, we summarized the studies that reported the association among the delivery factors and neonatal thyroid hormones and thyroid stimulating hormone. A comprehensive literature search was performed in PubMed, Web of Science, and Scopus up to March 2020, to identify the studies investigating the relationship between delivery factors, especially the mode of delivery and labor pain, and neonatal thyroid hormones and TSH. Finally, in this review study, of 157 articles obtained in the initial search, 25 eligible studies were reviewed. Various maternal, fetal/neonatal, and obstetric factors affected neonatal TSH and thyroid hormones. Among various influencing factors, mode of delivery, labor pains, and duration of labor have a strong relationship with neonatal thyroid hormones and need to be considered for interpretation of neonatal thyroid status. The majority of the studies revealed that vaginal deliveries (instrumental or natural) lead to higher levels of cord TSH compared to elective cesarean section. This can be explained by the increased secretion of catecholamine during labor. It has been suggested that blood TSH and thyroid hormone levels are affected by perinatal stress events such as maternal anxiety, labor pains, fetal distress, and other stimulants of the catecholamine response. These changes may act as the trigger to increase thyroid hormone levels for adapting of neonates in the first hours after birth. This assumption needs to be re-evaluated by performing comprehensive and well-designed studies.

Keywords: cesarean section; delivery; neonatal; thyroid hormones; vaginal delivery
Corresponding author: Sima Nazarpour, Assistant Professor, Department of Midwifery, College of Medical Sciences, Varamin-Pishva Branch, Islamic Azad University, Tehran, Iran; and Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24 Parvaneh, Yaman Street, Velenjak, P.O. Box: 19395-4763, 1985717413 Tehran, Iran, Phone: +98 21 22 43 25 00, Fax: +98 21 22 43 97 84, E-mail:

Acknowledgments

The authors would like to thank all authors of the primary studies included in this review.

  1. Research funding: None declared.

  2. Author contributions: Research idea and study design: S.N. and F.R.T.; data acquisition: S.N.; supervision: F.R.T.; Writing – original draft, S.N.; Writing – review & editing, F.R.T. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Informed consent: Not applicable. This study is a systematic review.

  5. Ethical approval: This study was approved by the ethics committee of the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences (Approval code: IR.SBMU.ENDOCRINE.REC.1399.010).

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2020-0740).

Received: 2020-12-26
Accepted: 2021-03-28
Published Online: 2021-04-22
Published in Print: 2021-07-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Delivery factors and neonatal thyroid hormone levels: a systematic review
  4. Original Articles
  5. Birth prevalence of tetrahydrobiopterin deficiency in China: data from the national newborn screening program, 2013–2019
  6. Analysis of the CAG tract length in the Androgen Receptor gene in Mexican patients with nonsyndromic cryptorchidism
  7. Pituitary hypoplasia is the best MRI predictor of the severity and type of growth hormone deficiency in children with congenital growth hormone deficiency
  8. Urinary gonadotropin measurements by enhanced luminometric assays (LIA) for the evaluation of pubertal development
  9. Challenges in management of transient hyperinsulinism – a retrospective analysis of 36 severely affected children
  10. Who should return for an oral glucose tolerance test? A proposed clinical pathway based on retrospective analysis of 332 children
  11. Investigation of the prevalence of cardiovascular risk factors in obese patients diagnosed with metabolic syndrome in childhood and examination of left ventricular function by echocardiography
  12. Effect of l-carnitine supplementation on children and adolescents with nonalcoholic fatty liver disease (NAFLD): a randomized, triple-blind, placebo-controlled clinical trial
  13. Management of patients with X-linked hypophosphatemic rickets during Covid-19 pandemic lockdown
  14. Evaluation of the pathophysiological role of Fetuin A levels in adolescents with polycystic ovary syndrome
  15. Gonadotropins for testicular descent in cryptorchid congenital hypogonadotropic hypogonadism males beyond infancy
  16. Clinical characteristics and outcome of hospitalized children and adolescent patients with type 1 diabetes during the COVID-19 pandemic: data from a single center surveillance study in Egypt
  17. Letter to the Editor
  18. Revisiting the effect of GnRH analogue treatment on bone mineral density in young adolescents with gender dysphoria
  19. Case Reports
  20. Pulmonary and cutaneous mucormycosis in two children with diabetes mellitus type 1
  21. Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis
  22. Barth syndrome with severe dilated cardiomyopathy and growth hormone resistance: a case report
  23. The utility of reverse phenotyping: a case of lysinuric protein intolerance presented with childhood osteoporosis
https://doi.org/10.1515/jpem-2020-0740
Schlagwörter für diesen Artikel
cesarean section; delivery; neonatal; thyroid hormones; vaginal delivery

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Delivery factors and neonatal thyroid hormone levels: a systematic review
  4. Original Articles
  5. Birth prevalence of tetrahydrobiopterin deficiency in China: data from the national newborn screening program, 2013–2019
  6. Analysis of the CAG tract length in the Androgen Receptor gene in Mexican patients with nonsyndromic cryptorchidism
  7. Pituitary hypoplasia is the best MRI predictor of the severity and type of growth hormone deficiency in children with congenital growth hormone deficiency
  8. Urinary gonadotropin measurements by enhanced luminometric assays (LIA) for the evaluation of pubertal development
  9. Challenges in management of transient hyperinsulinism – a retrospective analysis of 36 severely affected children
  10. Who should return for an oral glucose tolerance test? A proposed clinical pathway based on retrospective analysis of 332 children
  11. Investigation of the prevalence of cardiovascular risk factors in obese patients diagnosed with metabolic syndrome in childhood and examination of left ventricular function by echocardiography
  12. Effect of l-carnitine supplementation on children and adolescents with nonalcoholic fatty liver disease (NAFLD): a randomized, triple-blind, placebo-controlled clinical trial
  13. Management of patients with X-linked hypophosphatemic rickets during Covid-19 pandemic lockdown
  14. Evaluation of the pathophysiological role of Fetuin A levels in adolescents with polycystic ovary syndrome
  15. Gonadotropins for testicular descent in cryptorchid congenital hypogonadotropic hypogonadism males beyond infancy
  16. Clinical characteristics and outcome of hospitalized children and adolescent patients with type 1 diabetes during the COVID-19 pandemic: data from a single center surveillance study in Egypt
  17. Letter to the Editor
  18. Revisiting the effect of GnRH analogue treatment on bone mineral density in young adolescents with gender dysphoria
  19. Case Reports
  20. Pulmonary and cutaneous mucormycosis in two children with diabetes mellitus type 1
  21. Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis
  22. Barth syndrome with severe dilated cardiomyopathy and growth hormone resistance: a case report
  23. The utility of reverse phenotyping: a case of lysinuric protein intolerance presented with childhood osteoporosis
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