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Children and adolescent acceptability of a new device system to administer human growth hormone – a pilot study
-
Anne-Marie Kappelgaard
,
Søren Mikkelsen
Veröffentlicht/Copyright:
10. Februar 2012
Abstract
Background: Growth hormone (GH) is used to treat growth failure in children and metabolic impairments in adults with GH deficiency (GHD). Treatment requires daily subcutaneous injections that may affect treatment outcomes, and subsequently efficacy outcomes. To enhance potential adherence, improved GH delivery device systems are being developed.
Objective: To compare patient acceptability and usability of Norditropin® FlexPro®/FlexPro® PenMate® with Norditropin NordiFlex®/NordiFlex PenMate® for GH administration in children/adolescents with GHD.
Methods: A multinational, open-label, uncontrolled study. Patients (n=50; 4–18 years) currently on GH therapy injected test medium into a foam pad. Ease-of-use and patient device preference were recorded by questionnaire.
Results: The majority (80%) of patients preferred FlexPro® PenMate® over NordiFlex PenMate® with 96% and 84%, respectively, reporting that they found the FlexPro® PenMate®system user-friendly and that they were highly confident using it.
Conclusion: The FlexPro system was well accepted by patients. This may facilitate greater adherence to treatment and improve patient outcomes.
Keywords: acceptability; FlexPro; growth hormone deficiency; Nordiflex; paediatrics; pen device; PenMate
Received: 2011-8-16
Accepted: 2011-12-10
Published Online: 2012-02-10
Published in Print: 2012-04-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
acceptability;
FlexPro;
growth hormone deficiency;
Nordiflex;
paediatrics;
pen device;
PenMate
Artikel in diesem Heft
- Review Articles
- Peptide YY in children: a review
- Brown adipose tissue: distribution and influencing factors on FDG PET/CT scan
- Mini Review
- Approach to the management of slipped capital femoral epiphysis and primary hyperparathyroidism
- Original Articles
- Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples
- Elevated serum ferritin and soluble transferrin receptor in infants with congenital hypothyroidism
- Implications of gastrointestinal hormones in the pathogenesis of obesity in prepubertal children
- Oxidative stress in obese children and its relation with insulin resistance
- Final height in elite male artistic gymnasts
- Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
- Evaluation of skeletal maturity score for Korean children and the standard for comparison of bone age and chronological age in normal children
- Children and adolescent acceptability of a new device system to administer human growth hormone – a pilot study
- The analysis of clinical manifestations and genetic mutations in Chinese boys with primary adrenal insufficiency
- Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns
- Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone
- Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression
- Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birth
- Patient Reports
- Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
- Palmoplantar keratoderma with growth hormone deficiency
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- Autonomous functioning thyroid nodule successfully treated with radioiodine in a 3 and a half-year-old boy
- Hashimoto thyroiditis associated with ataxia telangiectasia
- Improved long-term glucose control in neonatal diabetes mellitus after early sulfonylurea allergy
- Stroke in a child with Adams-Oliver syndrome and mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome
- A novel mutation of the insulin receptor gene in a preterm infant with Donohue syndrome and heart failure
- Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas
- Successful prospective management of neonatal citrullinemia
- A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene
- Warburg Micro syndrome
- Inguinal ovary as a rare diagnostic sign of Mayer-Rokitansky-Küster-Hauser syndrome
- Letters to the Editor
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