Article
Licensed
Unlicensed
Requires Authentication
Stroke in a child with Adams-Oliver syndrome and mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome
-
Benjamin U. Nwosu
,
Seema Adhami
Published/Copyright:
February 27, 2012
Abstract
Diabetes mellitus complicated by mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome presents a special challenge to physicians. There is no standard protocol for the management of mixed hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis in children. The commonest cause of neurological deterioration during an episode of diabetic ketoacidosis is cerebral edema, whereas hyperosmolality often leads to thrombosis. The risks for these complications are further increased in diseases associated with vasculopathies. We present the first case of complex cerebral arteriovenous thrombosis leading to stroke in a child with Adams-Oliver syndrome, a genetic condition that is associated with abnormal vasculogenesis. He presented with new-onset double diabetes complicated by a combination of diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome. Magnetic resonance imaging, magnetic resonance angiography, and magnetic resonance venography provided evidence for an ischemic stroke. Children and adolescents who present with a combination of hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis should be monitored for neurologic deficits and must be investigated for both stroke and cerebral edema in the event of neurological deterioration.
Keywords: Adams-Oliver syndrome; diabetic ketoacidosis; double diabetes; hyperglycemic hyperosmolar syndrome
Received: 2011-12-1
Accepted: 2012-1-4
Published Online: 2012-02-27
Published in Print: 2012-04-01
©2012 by Walter de Gruyter Berlin Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Review Articles
- Peptide YY in children: a review
- Brown adipose tissue: distribution and influencing factors on FDG PET/CT scan
- Mini Review
- Approach to the management of slipped capital femoral epiphysis and primary hyperparathyroidism
- Original Articles
- Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples
- Elevated serum ferritin and soluble transferrin receptor in infants with congenital hypothyroidism
- Implications of gastrointestinal hormones in the pathogenesis of obesity in prepubertal children
- Oxidative stress in obese children and its relation with insulin resistance
- Final height in elite male artistic gymnasts
- Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
- Evaluation of skeletal maturity score for Korean children and the standard for comparison of bone age and chronological age in normal children
- Children and adolescent acceptability of a new device system to administer human growth hormone – a pilot study
- The analysis of clinical manifestations and genetic mutations in Chinese boys with primary adrenal insufficiency
- Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns
- Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone
- Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression
- Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birth
- Patient Reports
- Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
- Palmoplantar keratoderma with growth hormone deficiency
- Propylthiouracil hepatitis: report of a case and extensive review of the literature
- Autonomous functioning thyroid nodule successfully treated with radioiodine in a 3 and a half-year-old boy
- Hashimoto thyroiditis associated with ataxia telangiectasia
- Improved long-term glucose control in neonatal diabetes mellitus after early sulfonylurea allergy
- Stroke in a child with Adams-Oliver syndrome and mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome
- A novel mutation of the insulin receptor gene in a preterm infant with Donohue syndrome and heart failure
- Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas
- Successful prospective management of neonatal citrullinemia
- A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene
- Warburg Micro syndrome
- Inguinal ovary as a rare diagnostic sign of Mayer-Rokitansky-Küster-Hauser syndrome
- Letters to the Editor
- Endocrine disruptors and fulminant type 1 diabetes: is there a link?
- The appropriate use of sensitive tests of hypothalamic-pituitary-adrenal-axis suppression
- Meetings
- Meetings Calendar
- Masthead
- Masthead
Keywords for this article
Adams-Oliver syndrome;
diabetic ketoacidosis;
double diabetes;
hyperglycemic hyperosmolar syndrome
Articles in the same Issue
- Review Articles
- Peptide YY in children: a review
- Brown adipose tissue: distribution and influencing factors on FDG PET/CT scan
- Mini Review
- Approach to the management of slipped capital femoral epiphysis and primary hyperparathyroidism
- Original Articles
- Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples
- Elevated serum ferritin and soluble transferrin receptor in infants with congenital hypothyroidism
- Implications of gastrointestinal hormones in the pathogenesis of obesity in prepubertal children
- Oxidative stress in obese children and its relation with insulin resistance
- Final height in elite male artistic gymnasts
- Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
- Evaluation of skeletal maturity score for Korean children and the standard for comparison of bone age and chronological age in normal children
- Children and adolescent acceptability of a new device system to administer human growth hormone – a pilot study
- The analysis of clinical manifestations and genetic mutations in Chinese boys with primary adrenal insufficiency
- Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns
- Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone
- Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression
- Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birth
- Patient Reports
- Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
- Palmoplantar keratoderma with growth hormone deficiency
- Propylthiouracil hepatitis: report of a case and extensive review of the literature
- Autonomous functioning thyroid nodule successfully treated with radioiodine in a 3 and a half-year-old boy
- Hashimoto thyroiditis associated with ataxia telangiectasia
- Improved long-term glucose control in neonatal diabetes mellitus after early sulfonylurea allergy
- Stroke in a child with Adams-Oliver syndrome and mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome
- A novel mutation of the insulin receptor gene in a preterm infant with Donohue syndrome and heart failure
- Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas
- Successful prospective management of neonatal citrullinemia
- A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene
- Warburg Micro syndrome
- Inguinal ovary as a rare diagnostic sign of Mayer-Rokitansky-Küster-Hauser syndrome
- Letters to the Editor
- Endocrine disruptors and fulminant type 1 diabetes: is there a link?
- The appropriate use of sensitive tests of hypothalamic-pituitary-adrenal-axis suppression
- Meetings
- Meetings Calendar
- Masthead
- Masthead
