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Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns
-
Kelli K. Ryckman
,
Daniel E. Cook
Published/Copyright:
February 15, 2012
Abstract
Nationally, newborn screening programs use 17-hydroxyprogesterone (17-OHP) as the biomarker to detect the rare but potentially fatal inherited disease, congenital adrenal hyperplasia. However, this biomarker is highly variable, with a high false-positive rate of detection, particularly in neonates born preterm. Several studies have examined various clinical and genetic factors to explain the variability of 17-OHP in preterm infants. The purpose of this study was to replicate previous clinical and genetic associations with 17-OHP in a well-characterized cohort of 762 preterm infants. We replicated previous findings that respiratory distress syndrome (p=2×10–3) is associated with higher 17-OHP. Higher 17-OHP and false positives were significantly associated with lower gestational age and birth weight, as previously reported. Incorporating gestational age and birth weight together decreases the false-positive rate.
Received: 2011-11-20
Accepted: 2012-1-23
Published Online: 2012-02-15
Published in Print: 2012-04-01
©2012 by Walter de Gruyter Berlin Boston
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Keywords for this article
congenital adrenal hyperplasia;
hydroxyprogesterone;
respiratory distress syndrome
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- Original Articles
- Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples
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