Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice

Nyamsurendejid Delgersaikhan; Erdenezaya Odkhuu; Purevsuren Khaltar; Enkhbaatar Samdan; Uranchimeg Dugarsuren; Shine-Od Dalkhsuren; Amgalanbaatar Dorjkhuu; Dolgorsuren Aldartsogt; Avirmed Amgalanbaatar

doi:10.1515/jcim-2024-0316

Artikel

Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice

Nyamsurendejid Delgersaikhan , Erdenezaya Odkhuu , Purevsuren Khaltar , Enkhbaatar Samdan , Uranchimeg Dugarsuren , Shine-Od Dalkhsuren , Amgalanbaatar Dorjkhuu , Dolgorsuren Aldartsogt und Avirmed Amgalanbaatar

Veröffentlicht/Copyright: 11. November 2024

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Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 21 Heft 4

Abstract

Objectives

The Inonotus obliquus is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural Inonotus obliquus on alloxan-induced diabetic mice.

Methods

Alloxan monohydrate (200 mg/kg) was intraperitoneally single injected into C57BL/6 mice to induce diabetes. Alloxan-induced diabetic mice were orally given the water extract of inonotus obliquus (WEIO) at doses of 500 mg/kg and subcutaneously administered with insulatard 0.6 IU for 4 weeks. Subsequently, the levels of factors related to blood glucose, insulin and lipids were assessed.

Results

WEIO significantly restored body weight, reduced fasting blood glucose levels, improved glucose tolerance ability, and increased insulin levels compared to the control diabetic mice. WEIO also enhanced cholesterol transportation in the liver, correlated with increased HDL-C levels and decreased TC, TG and LDL-C levels. Histologic examinations revealed that WEIO alleviated alloxan-induced pancreatic tissue damage.

Conclusions

Natural Mongolian I. Obliquus water extracts have an antihyperglycemic effect and enhance islet cell function in alloxan-induced diabetic mice. It is a good candidate for a hypoglycemic functional food or medicine.

Keywords: antihyperglycemic; Inonotus obliquus; water extract; alloxan; diabetes

Corresponding author: Professor Avirmed Amgalanbaatar, MD, PhD, Department of Anatomy, 106188 School of Bio-Medicine, Mongolian National University of Medical Sciences , Ulaanbaatar 14210, Mongolia, E-mail: avirmed.a@mnums.edu.mn

Funding source: This work was supported by the Rector’s Research Grant of MNUMS

Award Identifier / Grant number: [â„–2024/013]

Acknowledgments

We thank Enkhdelger Munkhtuvshin (MD, MSc), Galindev Batnasan (PhD), and Herlenchimeg Nyamsuren (PhD) for the technical support and for identifying the plant.

Research ethics: The research was approved by the Research Ethics Committee of the Mongolian National University of Medical Sciences (the ethical approval no. 2016-/3-2016-22).
Informed consent: Not applicable.
Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Use of Large Language Models, AI and Machine Learning Tools: None declared.
Conflict of interest: The authors state no conflict of interest.
Research funding: This work was supported by the Rector’s Research Grant of MNUMS [№2024/013].
Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2024-09-11

Accepted: 2024-10-17

Published Online: 2024-11-11

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Artikel in diesem Heft

https://doi.org/10.1515/jcim-2024-0316

Schlagwörter für diesen Artikel

antihyperglycemic; Inonotus obliquus; water extract; alloxan; diabetes