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Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease

  • Seyyed Majid Bagheri , Mohammad Allahtavakoli and Alireza Moradi EMAIL logo
Published/Copyright: March 3, 2023
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 21 Issue 4

Abstract

One of the current strategies in the treatment of Alzheimer’s disease is using drugs with acetylcholinesterase (AChE) inhibitory property. The existence of various compounds in plants as a potential source for finding new compounds to treat Alzheimer’s disease is a scientific fact. Many secondary metabolites and plant extracts have been reported with the ability to inhibit the AChE activity and improve memory and learning. These compounds can increase the concentration of acetylcholine in the brain and improve cholinergic function in individuals with Alzheimer’s disease and reduce the symptoms of this neurological disorder. Plants of Ferula genus are a good source of biologically active compounds such as sesquiterpene derivatives, coumarin derivatives and sulfur-containing compounds. Numerous studies on various extracts or purified compounds of Ferula genus have shown that members of this genus have the inhibitory properties on acetylcholinesterase and can also be effective in improving Alzheimer’s and amnesia. This review article summarizes studies on plants of Ferula extracts and their derived compounds to find AChE inhibitors.

Keywords: acetylcholinesterase inhibitors; Alzheimer’s disease; Ferula
Corresponding author: Alireza Moradi, Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yard, Iran, Phone: +98 3538203419, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Received: 2022-08-18
Accepted: 2023-02-10
Published Online: 2023-03-03
Published in Print: 2024-12-17

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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  5. A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent
  6. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease
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https://doi.org/10.1515/jcim-2022-0284
Keywords for this article
acetylcholinesterase inhibitors; Alzheimer’s disease; Ferula

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. A new chapter in traditional, complementary, and integrative medicine: Advancing the Journal of Complementary and Integrative Medicine through open science, meta-research, artificial intelligence, and early career researcher involvement
  4. Reviews
  5. A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent
  6. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease
  7. The use of biofield energy therapy as complementary and alternative medicine in human health care system: a narrative review and potential mechanisms
  8. Research Articles
  9. Exploration of neuroprotective and cognition boosting effects of Mazus pumilus in Alzheimer’s disease model
  10. Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice
  11. Anti-inflammatory activity of Ziziphus jujuba hydroalcoholic extract in acetic acid-induced ulcerative colitis model
  12. Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of Pandanus odoratissimus leaves
  13. Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration
  14. Phytochemical analysis and acute toxicity study of seaweed Halimeda macroloba using Wistar albino rats
  15. Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats
  16. Galactagogue activity of poly-herbal decoction from Indonesia: a randomized open label controlled trial
  17. The role of nutraceuticals in the management of temporomandibular disorders
  18. The use of complementary and alternative medicine (CAM) during pregnancy
  19. Congress Abstracts
  20. Abstracts for INCAM Research Symposium 2024: Traditions, Transitions & Tipping Points: Exploring the Relevance & Impact of Integrative Health Research on Individuals, Communities, and the Planet
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