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A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent

  • Aliya Naz , Abhiroop Chowdhury , Shubhra Pareek , Pushpendra Kumar and Nitesh Kumar Poddar ORCID logo EMAIL logo
Published/Copyright: October 10, 2024
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 21 Issue 4

Abstract

Plants are crucial medicinal resources, with 80 % of people relying on them for primary healthcare. The search for natural antiviral compounds is increasing, especially in semi-arid ecosystems where abiotic stress promotes the production of beneficial secondary metabolites. This review highlights semi-arid plants with the potential as functional foods to combat viral diseases and other illnesses. Literature was searched in databases like ScienceDirect to gather information on novel compounds from stress-tolerant semi-arid plant species. These compounds have potential uses in treating viral infections and other health issues such as diabetes and high blood pressure. The review screened 61 semi-arid plants known for their antiviral metabolites. Eight plants were identified with novel antiviral compounds. Key metabolites include agathisflavone, pectic arabinogalactan, azadirachtin, aloin, aloe-emodin, aloesaponarin I, allicin, terpenoids, chlorogenic acids, curcumin, chromones, β-sitosterol, lupeol, oleuropein, carissol, β-amyrin, and ∆-9-tetrahydrocannabinol. Stress-tolerant semi-arid plants are significant sources of metabolites for treating infectious diseases and boosting immune systems. Further research on these metabolites in animal models is needed to verify their efficacy for treating human diseases during endemic and pandemic outbreaks, such as COVID-19.

Keywords: active principle; anti-viral; ethnomedicine; pharmacognosy; semiarid; secondary metabolites
Corresponding author: Dr. Nitesh Kumar Poddar, Department of Biosciences, Manipal University Jaipur, Dehmi Kalan, Jaipur-Ajmer Expressway, Jaipur, 303007, Rajasthan, India, E-mail:
Aliya Naz and Abhiroop Chowdhury contributed equally as the first authors.

Acknowledgments

Financial support to Department of Biosciences, Manipal University Jaipur, in the form of DST-FIST project (DST/2022/1012) from Govt. of India, is gratefully acknowledged.

  1. Research ethics: The local Institutional Review Board deemed the study exempt from review.

  2. Informed consent: Informed consent was obtained from all individuals included in this study.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: Authors state no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Not applicable.

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Received: 2024-05-27
Accepted: 2024-09-13
Published Online: 2024-10-10

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. A new chapter in traditional, complementary, and integrative medicine: Advancing the Journal of Complementary and Integrative Medicine through open science, meta-research, artificial intelligence, and early career researcher involvement
  4. Reviews
  5. A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent
  6. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease
  7. The use of biofield energy therapy as complementary and alternative medicine in human health care system: a narrative review and potential mechanisms
  8. Research Articles
  9. Exploration of neuroprotective and cognition boosting effects of Mazus pumilus in Alzheimer’s disease model
  10. Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice
  11. Anti-inflammatory activity of Ziziphus jujuba hydroalcoholic extract in acetic acid-induced ulcerative colitis model
  12. Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of Pandanus odoratissimus leaves
  13. Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration
  14. Phytochemical analysis and acute toxicity study of seaweed Halimeda macroloba using Wistar albino rats
  15. Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats
  16. Galactagogue activity of poly-herbal decoction from Indonesia: a randomized open label controlled trial
  17. The role of nutraceuticals in the management of temporomandibular disorders
  18. The use of complementary and alternative medicine (CAM) during pregnancy
  19. Congress Abstracts
  20. Abstracts for INCAM Research Symposium 2024: Traditions, Transitions & Tipping Points: Exploring the Relevance & Impact of Integrative Health Research on Individuals, Communities, and the Planet
https://doi.org/10.1515/jcim-2024-0186
Keywords for this article
active principle; anti-viral; ethnomedicine; pharmacognosy; semiarid; secondary metabolites

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. A new chapter in traditional, complementary, and integrative medicine: Advancing the Journal of Complementary and Integrative Medicine through open science, meta-research, artificial intelligence, and early career researcher involvement
  4. Reviews
  5. A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent
  6. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease
  7. The use of biofield energy therapy as complementary and alternative medicine in human health care system: a narrative review and potential mechanisms
  8. Research Articles
  9. Exploration of neuroprotective and cognition boosting effects of Mazus pumilus in Alzheimer’s disease model
  10. Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice
  11. Anti-inflammatory activity of Ziziphus jujuba hydroalcoholic extract in acetic acid-induced ulcerative colitis model
  12. Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of Pandanus odoratissimus leaves
  13. Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration
  14. Phytochemical analysis and acute toxicity study of seaweed Halimeda macroloba using Wistar albino rats
  15. Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats
  16. Galactagogue activity of poly-herbal decoction from Indonesia: a randomized open label controlled trial
  17. The role of nutraceuticals in the management of temporomandibular disorders
  18. The use of complementary and alternative medicine (CAM) during pregnancy
  19. Congress Abstracts
  20. Abstracts for INCAM Research Symposium 2024: Traditions, Transitions & Tipping Points: Exploring the Relevance & Impact of Integrative Health Research on Individuals, Communities, and the Planet
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