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Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats

  • Mellina S. Simões , Ana Beatriz P. Souza , Francielli M.S. Silva-Comar , Ciomar A. Bersani-Amado , Roberto K.N. Cuman , Rosane M. Peralta , Anacharis B. Sá-Nakanishi , Lívia Bracht , Adelar Bracht and Jurandir F. Comar EMAIL logo
Published/Copyright: August 28, 2024
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 21 Issue 4

Abstract

Objectives

Resveratrol has been studied as a potential agent for treating rheumatic conditions; however, this compound suppresses glucose synthesis and glycogen catabolism when infused in perfused livers of both arthritic and healthy rats. This study investigated the effects of oral administration of resveratrol on inflammation and liver metabolism in rats with arthritis induced by Freund’s adjuvant, which serves as rheumatoid arthritis model.

Methods

Holtzman rats, both healthy and exhibiting arthritic symptoms, were orally treated with resveratrol at doses varying from 25 to 500 mg/kg for a 5-day period preceding arthritis induction, followed by an additional 20-day period thereafter. Paw edema, arthritic score and hepatic myeloperoxidase activity were assessed to evaluate inflammation. Glycogen catabolism and gluconeogenesis from lactate were respectively evaluated in perfused livers from fed and fasted rats.

Results

Resveratrol decreased the liver myeloperoxidase activity at doses above 100 mg/kg, and decreased the paw edema and delayed the arthritic score at doses above 250 mg/kg. The hepatic gluconeogenesis was decreased in arthritic rats and resveratrol did not improve it. However, resveratrol did not negatively modify the gluconeogenesis in livers of healthy and arthritic rats. Glycogen catabolism was in part and slightly modified by resveratrol in the liver of arthritic and healthy rats.

Conclusions

It is improbable that resveratrol negatively affects the liver metabolism, especially considering that gluconeogenesis is highly fragile to changes in cellular architecture. The findings suggest that resveratrol could serve as alternative for treating rheumatoid arthritis. Nevertheless, prudence is advised regarding its transient effects on liver metabolism.

Keywords: rheumatic diseases; resveratrol; hepatic metabolism; gluconeogenesis; rheumatoid arthritis
Corresponding author: Jurandir F. Comar, Department of Biochemistry, State University of Maringá, 87020900 Maringá, PR, Brazil, E-mail:

Funding source: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Award Identifier / Grant number: 312464/2020-7

  1. Research ethics: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Experiments were performed under a project license (NO.: 2495130916) granted by the Ethics Committee for Animal Experimentation (CEUA) of the State University of Maringá (UEM), in compliance with the guidelines of the Brazilian Council for the Control of Animal Experimentation (CONCEA).

  2. Informed consent: Not applicable.

  3. Author contributions: All the authors have accepted responsibility for the entire content of this manuscript and approved submission. Individual contributions: (I) conception and design: Jurandir F Comar; (II) administrative support: all authors; (III) provision of study materials or patients: none; (IV) collection and assembly of data: Mellina S Simões, Ana Beatriz P. Souza, Francielli M S Silva-Comar, Lívia Bracht and Anacharis B Sá-Nakanishi; (V) data analysis and interpretation: Jurandir F Comar, Roberto K N Cuman, Rosane M Peralta, Ciomar A Bersani-Amado and Adelar Bracht; (VI) manuscript writing: all authors; (VII) final approval of manuscript: all authors.

  4. Competing interests: The authors declare that no competing interest exists.

  5. Research funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Grant number: 312464/2020-7.

  6. Data availability: The raw data can be obtained on request from the corresponding author.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jcim-2024-0200).

Received: 2024-06-10
Accepted: 2024-08-06
Published Online: 2024-08-28

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2024-0200
Keywords for this article
rheumatic diseases; resveratrol; hepatic metabolism; gluconeogenesis; rheumatoid arthritis

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. A new chapter in traditional, complementary, and integrative medicine: Advancing the Journal of Complementary and Integrative Medicine through open science, meta-research, artificial intelligence, and early career researcher involvement
  4. Reviews
  5. A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent
  6. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease
  7. The use of biofield energy therapy as complementary and alternative medicine in human health care system: a narrative review and potential mechanisms
  8. Research Articles
  9. Exploration of neuroprotective and cognition boosting effects of Mazus pumilus in Alzheimer’s disease model
  10. Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice
  11. Anti-inflammatory activity of Ziziphus jujuba hydroalcoholic extract in acetic acid-induced ulcerative colitis model
  12. Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of Pandanus odoratissimus leaves
  13. Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration
  14. Phytochemical analysis and acute toxicity study of seaweed Halimeda macroloba using Wistar albino rats
  15. Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats
  16. Galactagogue activity of poly-herbal decoction from Indonesia: a randomized open label controlled trial
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