Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution
-
Patrick Emeka Aba
and
Christian Onwuchekwa Okorie-kanu
Abstract
Background
Quail egg is said to heal all sorts of ailments including diabetes and liver diseases, and people have started taking it indiscriminately without verification and standardization. This study investigated some biochemical effects associated with administration of varying concentrations of quail egg solution to alloxanized rats.
Methods
Thirty (30) adult male albino Wistar rats were assigned to 5 groups of 6 rats each. Groups 2–5 rats were injected with alloxan monohydrate intraperitoneally at the dose of 160 mg/kg while rats in group 1 served as normal control. Upon establishment of fasting blood glucose level above 126 mg/dL, the rats in groups 2–4 were administered 30, 15, and 7.5 mg/mL of quail egg solution respectively for 7 days. Rats in groups 1 and 5 received distilled water (10 mL/kg) each. All treatments were through the oral route. At the end of 7 days duration of the study, blood samples for some biochemical (alanine aminotransferase [ALT] and blood urea nitrogen [BUN]) analyses were collected.
Results
Results indicated that the quail egg administration to alloxanized rats especially at the concentration of 30 mg/mL significantly (p<0.5) reduced the elevated levels of ALT and BUN.
Conclusions
It was concluded that administration of quail egg solution to alloxanized rats mitigated hepatic injury and ameliorated renal lesion that may have resulted from the effect of alloxan monohydrate.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Stadelman W. Egg science and technology. New York:Haworth Press, 1995.Search in Google Scholar
2. Agarwal SK, Bhanja SK, Majumdar S. Effect of cage floor space on the egg production performance of japanese quail (Coturnix coturnix japonica) during winter. Indian J Poult Sci. 2006;41:205–207.Search in Google Scholar
3. Kostova Z, Gerzilov V, Kutserv T. Morphological characteristics and chemical composition of Japanese quail eggs. Higher Inst Agric Sci Works. 1993;38:193–196.Search in Google Scholar
4. Szkudelski T. The mechanism of alloxan and streptozoticin action in beta cells of the rat pancreas. Physiol Res. 2001;56:537–546.10.33549/physiolres.930111Search in Google Scholar
5. Kaehler W, Kukliinski B, Ruehlmann C, Plotz C. Diabetes mellitus - a free radical-associated disease. Results of adjuvant antioxidant supplementation. Z Gesante Inn Med. 1993;48:223–232 .Search in Google Scholar
6. Adesokan AA, Oyewole OI, Turray BM. Kidney and liver function parameters in alloxan-induced diabetic rats treated with Aloe barbadensis juice extract. Sierra Leone J Biomed Res. 2009;1:33–37.10.4314/sljbr.v1i1.52431Search in Google Scholar
7. El-Dermardash FM, Yousy MV, EL-Waga NI. Biochemical study on the hypoglycaemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol. 2005;43:57–63.10.1016/j.fct.2004.08.012Search in Google Scholar
8. Venogopal PM, Prince PS, Pari L. Hypoglycemic activities of Syzigium cumini seeds effect on lipid peroxidation in alloxan diabetic rats. J Ethnopharm. 1998;61:1–7.10.1016/S0378-8741(98)00002-6Search in Google Scholar
9. Reitman S, Frankel S. A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transminases. Am J Clin Path. 1957;28:56–62.10.1093/ajcp/28.1.56Search in Google Scholar PubMed
10. Fawcett JK, Scott JE. A rapid and precise method for the determination of urea. J Clin Path. 1960;13:156–159.10.1136/jcp.13.2.156Search in Google Scholar PubMed PubMed Central
11. Yusuf AB, Umar IA, Nok AJ. Effects of methanol extract of Vernonia amygdalina leaf on survival and some biochemical parameters in acute Trypanosoma brucei brucei infection. Afr J Biochem Res. 2012;6:150–158.Search in Google Scholar
12. Richard D, Kefi K, Barbe U, Bausero P, Visioli F. Polyunsaturated fatty acids as antioxidants. Pharmacol Res. 2008;57:451–455.10.1016/j.phrs.2008.05.002Search in Google Scholar PubMed
13. Braide LM, Anika SM. Environmental toxicology, 1st ed. Enugu:SNAAP Press Ltd, 2009:89–99.Search in Google Scholar
14. Aba PE, Asuzu IU. Effects of administration of methanol root bark extract of Cussonia arborea on serum biochemical markers of kidney damage and renal histomorphology of alloxan-induced diabetic rats. J Adv Med Pharm Sci. 2015;5:1–9.10.9734/JAMPS/2016/22121Search in Google Scholar
© 2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Review
- Cornus mas: a review on traditional uses and pharmacological properties
- Preclinical Studies
- Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)
- Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function
- Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation
- Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution
- Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
- Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
- Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles
- Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction
- Clinical Studies
- Development and validation of a yoga module for Parkinson disease
- Case Report
- Return to work program efficacy with Self-Regulation Therapy (SRT®): Case study with complex trauma and concurrent disorders
Articles in the same Issue
- Review
- Cornus mas: a review on traditional uses and pharmacological properties
- Preclinical Studies
- Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)
- Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function
- Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation
- Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution
- Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
- Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
- Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles
- Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction
- Clinical Studies
- Development and validation of a yoga module for Parkinson disease
- Case Report
- Return to work program efficacy with Self-Regulation Therapy (SRT®): Case study with complex trauma and concurrent disorders
