Phytochemical screening and toxicity studies on the methanol extract of the seeds of moringa oleifera
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Temitayo Olabisi Ajibade
,
Ruben Arowolo
Abstract: The seeds of Moringa oleifera were collected, air-dried, pulverized, and subjected to cold extraction with methanol. The methanol extract was screened phytochemically for its chemical components and used for acute and sub-acute toxicity studies in rats. The phytochemical screening revealed the presence of saponins, tannins, terpenes, alkaloids, flavonoids, carbohydrates, and cardiac glycosides but the absence of anthraquinones. Although signs of acute toxicity were observed at a dose of 4,000 mg kg−1 in the acute toxicity test, and mortality was recorded at 5,000 mg kg−1, no adverse effect was observed at concentrations lower than 3,000 mg kg−1. The median lethal dose of the extract in rat was 3,873 mg kg−1. Sub-acute administration of the seed extract caused significant (p<0.05) increase in the levels of alanine and aspartate transferases (ALT and AST), and significant (p<0.05) decrease in weight of experimental rats, at 1,600 mg kg−1. The study concludes that the extract of seeds of M. oleifera is safe both for medicinal and nutritional uses.
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Artikel in diesem Heft
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Artikel in diesem Heft
- Masthead
- Masthead
- Phytochemistry & Product Quality
- Chemical and pharmacological standardization of Ashwagandhadi lehyam: an ayurvedic formulation
- Phytochemical screening and toxicity studies on the methanol extract of the seeds of moringa oleifera
- First report of fingerprinting dried herbal products using a subtractive diversity array
- Preclinical Studies
- Antidiabetic and antihypertensive effect of Virgin Argan Oil in model of neonatal streptozotocin-induced diabetic and l-nitroarginine methylester (l-NAME) hypertensive rats
- Hypoglycemic activity of the Anisopus mannii N. E. Br. methanolic leaf extract in normal and alloxan-induced diabetic mice
- Aloe vera gel protects liver from oxidative stress-induced damage in experimental rat model
- Hepatoprotective activity of Calotropis gigantea flowers against carbon-tetrachloride-induced liver damage in mice
- In vivo and in vitro estrogenic activity of extracts from Erythrina poeppigiana (Fabaceae)
- Liposomal-formulated curcumin [Lipocurc™] targeting HDAC (Histone Deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: implications for epigenetics-based nanotechnology-driven drug platform
- Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal rodent malaria parasite: Plasmodium berghei
- Structure elucidation and inhibitory effects on human platelet aggregation of chlorogenic acid from Wrightia tinctoria
- Cytotoxic effects of crocin on MOLT-4 human leukemia cells
- Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines
- Tea toxicity and cholinesterase inhibition of Huilliche herbal medicine
- Iatrogenic venous thrombosis secondary to supplemental medicine toxicity
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- The use of an anti-inflammatory supplement in patients with chronic kidney disease
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- Positive impact of Tai Chi Chuan participation on biopsychosocial quality of life compared to exercise and sedentary controls: a cross-sectional survey
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