Hepatoprotective activity of Calotropis gigantea flowers against carbon-tetrachloride-induced liver damage in mice
-
Deepa Krushna Ingawale
,
Satish Karbhari Mandlik
Abstract
Ethanol extract of Calotropis gigantea flowers (CGFE) was evaluated for its antioxidant and hepatoprotective activity to validate its use in traditional therapeutic indications. This CGFE exhibited significant antioxidant activity (at 20, 40, 60, 80 and 100 µg/ml in vitro) as evidenced by its hydroxyl, nitric oxide and hydrogen peroxide anion radical scavenging activities. This in vitro antioxidant activity was reinforced by a significant hepatoprotection (at 250 and 500 mg/kg dose) by decreasing the activity of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. The hepatoprotective activity of the CGFE was comparable with standard drug silymarin (100 mg/kg, p.o.).The results obtained from present study indicate the presence of natural antioxidants and hepatoprotective constituents. Hence, the above finding confirms in vitro antioxidant and hepatoprotective potential of CGFE in mice.
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©2013 by Walter de Gruyter Berlin / Boston
Articles in the same Issue
- Masthead
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Articles in the same Issue
- Masthead
- Masthead
- Phytochemistry & Product Quality
- Chemical and pharmacological standardization of Ashwagandhadi lehyam: an ayurvedic formulation
- Phytochemical screening and toxicity studies on the methanol extract of the seeds of moringa oleifera
- First report of fingerprinting dried herbal products using a subtractive diversity array
- Preclinical Studies
- Antidiabetic and antihypertensive effect of Virgin Argan Oil in model of neonatal streptozotocin-induced diabetic and l-nitroarginine methylester (l-NAME) hypertensive rats
- Hypoglycemic activity of the Anisopus mannii N. E. Br. methanolic leaf extract in normal and alloxan-induced diabetic mice
- Aloe vera gel protects liver from oxidative stress-induced damage in experimental rat model
- Hepatoprotective activity of Calotropis gigantea flowers against carbon-tetrachloride-induced liver damage in mice
- In vivo and in vitro estrogenic activity of extracts from Erythrina poeppigiana (Fabaceae)
- Liposomal-formulated curcumin [Lipocurc™] targeting HDAC (Histone Deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: implications for epigenetics-based nanotechnology-driven drug platform
- Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal rodent malaria parasite: Plasmodium berghei
- Structure elucidation and inhibitory effects on human platelet aggregation of chlorogenic acid from Wrightia tinctoria
- Cytotoxic effects of crocin on MOLT-4 human leukemia cells
- Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines
- Tea toxicity and cholinesterase inhibition of Huilliche herbal medicine
- Iatrogenic venous thrombosis secondary to supplemental medicine toxicity
- Clinical Studies
- Decreasing cardiovascular risk factors in obese individuals using a combination of PGX® meal replacements and PGX® granules in a 12-week clinical weight modification program
- The use of an anti-inflammatory supplement in patients with chronic kidney disease
- Impact of relaxation training according to the Yoga In Daily Life® system on anxiety after breast cancer surgery
- Positive impact of Tai Chi Chuan participation on biopsychosocial quality of life compared to exercise and sedentary controls: a cross-sectional survey
- Using a standardized Viniyoga protocol for lung cancer survivors: a pilot study examining effects on breathing ease
- Research utilization and evidence-based practice among Saskatchewan massage therapists
- Laser acupuncture in treatment of childhood bronchial asthma
- Case Reports
- Developing an in-patient acupuncture treatment in a pediatric hospital
- Reviews & Perspectives
- Is yoga an effective treatment in the management of patients with chronic low back pain compared with other care modalities – a systematic review
- Omega-3 fatty acid for the treatment and remission of Crohn’s disease
- Any role for probiotics in the therapy or prevention of autoimmune diseases? Up-to-date review
- Hericium erinaceus: an edible mushroom with medicinal values
- Are conduits superconductor-like and supported by tetrahedra structure of hyaluronic matrix in living systems? New perspectives
