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Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats

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Published/Copyright: July 17, 2019
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 30 Issue 4

Abstract

Background

We investigated the effects of a polyherbal formulation prepared from the extracts of Mondia whitei (Periplocaceae), Dracaena arborea (Dracaenaceae), and Bridelia ferruginea (Euphorbiaceae) (MDB) on the sexual behavior of normal rats (NR) and prediabetic rats (PR).

Methods

Male Wistar rats were administered with drinking fructose solution (21%) or tap water for 16 weeks. After induction of prediabetic status, NR (n = 30) and PR (n = 30) were randomly distributed into 10 groups of six animals each and orally treated with distilled water (10 mL/kg), sildenafil citrate (5 mg/kg), or MDB (50, 100, or 500 mg/kg) for 21 days. Sexual behavior parameters per series (S) of ejaculation were evaluated on days 1, 7, 14, and 21.

Results

Drinking fructose solution (21%) induced prediabetic status in rats, characterized by a significant (p < 0.01) increase in glycemia by 43.41% compared with the control group. MDB improved sexual performances of NR and PR by increasing the mount frequency (MF) and the intromission frequency (IF) as well as the number of rats capable of ejaculating. For instance, the MF and the IF were significantly increased in animals administered with MDB for 7 (50 mg/kg, S1 and S2), 14 (100 mg/kg, S3), or 21 days (100 or 500 mg/kg, S2). This increase was more pronounced on days 7 and 14 in NR and PR treated with sildenafil citrate or MDB extracts, respectively.

Conclusions

The mixture of MDB improved sexual activity in NR and PR. This result may further justify the traditional use of these plants as sexual performance enhancers.

Keywords: Bridelia ferruginea; Dracaena arborea; Mondia whitei; prediabetic rats; sexual behavior

Acknowledgments

The authors are grateful to the University of Dschang Cameroon for the research facilities. Special thanks to Jesse Forchap from Keck Graduate Institute, Rochester, New York, for polishing the English.

  1. Author contributions: PW and MATG designed and conducted the research. MATG, PBDD, EN, MWN, and GRFB participated in the data analysis and statistical analysis for the variables. PBDD, EN, MWN, and GRFB drafted the paper. AK and PK were responsible for the overall supervision. All the authors have accepted responsibility for the entire content of this manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: Authors state no potential conflict of interest.

  6. Ethical approval: The experiments were done in accordance to the internationally accepted standards of ethical guidelines for laboratory animal use and care as described in the European Economic Community Guidelines (Council Directive 86/609/EEC of 24 November 1986).

References

[1] Gundidza GM, Mmbengwa VM, Magwa ML, Ramalivhana NJ, Mukwevho NT, Daradzi WN, et al. Aphrodisiac properties of some Zimbabwean medicinal plants formulations. Afr J Biotechnol 2009;8:6402–7.10.5897/AJB09.430Search in Google Scholar

[2] Sandroni P. Aphrodisiacs past and present: a historical review. Clin Auton Res 2001;11:303–7.10.1007/BF02332975Search in Google Scholar PubMed

[3] Salmon PH. Psychosexual dysfunction in chronic renal failure: an overview. Proc EDTNA 1983;12:209–12.Search in Google Scholar

[4] Diosdado-Figueiredo M, Balboa-Barreiro V, Pértega-Diaz S, Seoane-Pillado T, Pita-Fernández S, Chantada-Abal V. Erectile dysfunction in patients with arterial hypertension. Cardiovascular risk and impact on their quality of life. Med Clin (Barc) 2018; pii: S0025-7753(18)30360-9. doi: 10.1016/j.medcli.2018.05.022.Search in Google Scholar PubMed

[5] Tsujimura A, Hiramatsu I, Aoki Y, Shimoyama H, Mizuno T, Nozaki T, et al. Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men. Prostate Int 2017;5:65–9.10.1016/j.prnil.2017.01.006Search in Google Scholar PubMed PubMed Central

[6] Deeh DP, Wankeu-Nya M, Ngadjui E, Bonsou FG, Kemka FX, Kamanyi A, et al. Palm oil diet-induced obesity impairs male rat reproductive performance. Ann Reprod Med Treat 2017a;2:1012.Search in Google Scholar

[7] Deeh DP, Wankeu-Nya M, Ngadjui E, Bonsou FG, Kemka FX, Kamanyi A, et al. The methanolic extract of Guibourtia tessmannii (Caesalpiniaceae) improves sexual parameters in high fat diet-induced obese sexually sluggish rats. APJR 2017b;5:202–11.10.4103/2305-0500.215930Search in Google Scholar

[8] Malavige LS, Jayaratne SD, Kathriarachchi ST, Sivayogan S, Ranasinghe P, Levy JC. Erectile dysfunction is a strong predictor of poor quality of life in men with type 2 diabetes mellitus. Diabet Med 2014;31:699–706.10.1111/dme.12412Search in Google Scholar PubMed

[9] Wankeu-Nya M, Florea A, Bâlici S, Watcho P, Matei H, Kamanyi A. Dracaena arborea alleviates ultra-structural spermatogenic alterations in streptozotocin-induced diabetic rats. Complement Altern Med 2013;13:71.10.1186/1472-6882-13-71Search in Google Scholar PubMed PubMed Central

[10] Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R. Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol 2001;166:569–74.10.1097/00005392-200108000-00036Search in Google Scholar

[11] Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989;320:1025–30.10.1056/NEJM198904203201601Search in Google Scholar PubMed

[12] El-Taher TS, Matalka Z, Taha HA, Badwan AA. Ferula harmonis ‘zallouh’ and enhancing erectile function in rats: efficacy and toxicity study. Int J Impot Res 2001;13:247–51.10.1038/sj.ijir.3900706Search in Google Scholar PubMed

[13] Adjanohoun JC, Aboubaker N, Dramane K, Ebot ME, Ekpere JA, Enow-Orock EG, et al. Traditional medicine and pharmacopoeia: contribution to ethnobotanical and floristic studies in Cameroon. Lagos: OUA/STRC, 1996.Search in Google Scholar

[14] Watcho P, Deeh DP, Wankeu-Nya M, Carro-Juarez M, Nguelefack TB, Kamanyi A. Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats. BMC Complement Altern Med 2013;13:4.10.1186/1472-6882-13-4Search in Google Scholar

[15] Watcho P, Zelefack F, Nguelefack TB, Ngouela S, Telefo PB, Kamtchouing P, et al. Effects of the aqueous and hexane extracts of Mondia whitei on the sexual behaviour and some fertility parameters of sexually inexperienced male rats. Afr J Tradit Complement Altern Med 2007;4:37–46.10.4314/ajtcam.v4i1.31190Search in Google Scholar

[16] Okunji CO, Iwu MM, Jackson JE, Tally JD. Biological activity of saponins from two Dracaena species. Adv Exp Med Biol 1996;404:415–8.10.1007/978-1-4899-1367-8_33Search in Google Scholar

[17] Wankeu-Nya M, Watcho P, Nguelefack TB, Carro-Juarez M, Tapondjou L, Kamanyi A. Effects of Dracaena arborea (Dracaenaceae) on sexual dysfunction in 4 weeks hyperglycemic male rats. Asian Pac J Trop Med 2014;7:609–19.10.1016/S1995-7645(14)60103-6Search in Google Scholar

[18] Irobi ON, Moo-Young M, Anderson WA, Daramola SO. Antimicrobial activity of bark extracts of Bridelia ferruginea (Euphorbiaceae). J Ethnopharmacol 1994;43:185–90.10.1016/0378-8741(94)90041-8Search in Google Scholar

[19] Burkil HM. The useful plants of west tropical Africa. Vol. 2. The Royal Botanic Garden, Kew. 1994, p. 636.Search in Google Scholar

[20] Gill LS. Ethnobotanical uses of plants in Nigeria. Benin City: University of Benin Press, 1992.Search in Google Scholar

[21] Akinsete TO, Adebayo-Tayo BC, Adekanmbi AO. The phytochemical and antimicrobial potentials of the crude extracts of Bridelia ferruginea and the extracellular biosynthesized silver nanoparticles. JAMPS 2017;14:1–13.10.9734/JAMPS/2017/34172Search in Google Scholar

[22] Watcho P, Nchegang B, Nguelefack TB. Kamanyi A. Evaluation of pro-sexual effects of Bridelia ferruginea extracts in sexually naive male rat. Androl 2010;20:209–15.10.1007/s12610-010-0094-zSearch in Google Scholar

[23] Oloro J, Tanayen J, Lius K, Barbra K, Lawrence I, Paul W, et al. Toxicity of four herbs used in erectile dysfunction; Mondia whiteii, Cola acuminata, Urtica massaica, and Tarenna graveolens in male rats. Afr J Pharm Pharmacol 2015;9:756–63.10.5897/AJPP2015.4299Search in Google Scholar

[24] Ido IO. Laboratory evaluation of toxic and repellent properties of Dracaena arborea against Sitophilus zeamais and Callosobruchus maculatus. Pak J Sci Ind Res 2011;54:152–6.10.52763/PJSIR.BIOL.SCI.54.3.2011.152.156Search in Google Scholar

[25] Bakoma B, Berké B, Eklu-Gadegbeku K, Agbonon A, Aklikokou K, Gbeassor M, et al. Acute and sub-chronic (28days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals. Food Chem Toxicol 2013;52:176–9.10.1016/j.fct.2012.11.021Search in Google Scholar PubMed

[26] EEC. Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. OJEC 1986;358:1–29.Search in Google Scholar

[27] Cariton AE. Experimental surgery of the genital system. In: Gay WI, Heavener JE, eds. Methods of animal experimentation: research surgery and care of the research animal. Part B: chirurgical approaches to organ systems. Orlando, FL: Academic Press Inc., 1988;7:191.Search in Google Scholar

[28] Watcho P, Wankeu-Nya M, Kamanyi A, Carro-Juarez M. Dracaena arborea extracts delay the pro-ejaculatory effect of dopamine and oxytocin in spinal male rats. Int J Impot Res 2014;26:213–7.10.1038/ijir.2014.13Search in Google Scholar PubMed

[29] Yakubu MT, Akanji MA. Effect of aqueous extract of Massularia acuminate stem on sexual behaviour of male Wistar rats. Evid Based Complement Alternat Med 2010; doi:10.1155/2011/738103. Article ID 738103, 10 pages.Search in Google Scholar PubMed PubMed Central

[30] Tajuddin SA, Abdul L, Iqbal AQ. Aphrodisiac activities of 50% ethanolic extracts of Mystica fragrans Houtt. (nutmeg) and Sysygium aromaticum (L) Merr. V α Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med 2003;3:1–5.10.1186/1472-6882-3-6Search in Google Scholar PubMed PubMed Central

[31] Mahajan GK, Mahajan AY, Mahajan RT. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males. J Complement Integr Med 2012;9:1.10.1515/1553-3840.1520Search in Google Scholar PubMed

[32] Hnatyszyn O, Moxatelli V, Rondina R, Costa M, Arranz C, Belaszczuk A, et al. Flavonoids from Achyzocline satureiodes with relaxant effects on the smooth muscle in Guinea pig corpus cavernosum. Phytomedicine 2004;11:366–9.10.1078/0944711041495182Search in Google Scholar PubMed

[33] Carro-Juàrez M, Cervantes E, Cervantes-Mendez M, Rodriguez-Menzo G. Aphrodisiac properties of the Montanoa tomentosa aqueous crude extract in male rats. Pharmacol Biochem Behav 2004;78:129–34.10.1016/j.pbb.2004.03.001Search in Google Scholar PubMed

[34] Basu A, Ryder RE. New treatment options for erectile dysfunction in patients with diabetes mellitus. Drugs 2004;64:2667–88.10.2165/00003495-200464230-00004Search in Google Scholar PubMed

[35] Mzimela NC, Ngubane PS, Khathi A. The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model. Autoimmunity 2019;52:27–36.10.1080/08916934.2019.1575820Search in Google Scholar PubMed

[36] Gamede M, Mabuza L, Ngubane P, Khathi A. Plant-derived oleanolic acid (OA) ameliorates risk factors of cardiovascular diseases in a diet-induced pre-diabetic rat model: effects on selected cardiovascular risk factors. Molecules 2019;24. pii: E340. doi: 10.3390/molecules24020340.Search in Google Scholar PubMed PubMed Central

[37] Heiker JT, Kunath A, Kosacka J, Flehmig G, Knigge A, Kern M, et al. Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains. Physiol Genomics 2014;46:377–84.10.1152/physiolgenomics.00014.2014Search in Google Scholar PubMed

[38] Noumi E, Amvam ZP, Lontsi D. Aphrodisiac plants used in Cameroon. Fitoterapia 1998;69:125–34.10.1016/S0367-326X(98)00025-2Search in Google Scholar

[39] Zanoli P, Benelli A, Zavatti M, Rivasi M, Baraldi C, Baraldi M. Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications. Asian J Androl 2008;10:937–45.10.1111/j.1745-7262.2008.00437.xSearch in Google Scholar PubMed

[40] Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A. Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behaviour of male rats. Psychopharmacology 1999;143:15–9.10.1007/s002130050913Search in Google Scholar PubMed

[41] Watcho P, Kamtchouing P, Sokeng SD, Moundipa PF, Tantchou J, Essame JL, et al. Androgenic effect of Mondia whitei roots in male rats. Asian J Androl 2004;6:269–72.Search in Google Scholar

[42] Ogunmodede OS, Oseni SO, Adenmosun OO, Oyekan JO. Dracaena arborea leaf extract: a phytotherapeutic option for ameliorating oxidative stress-mediated endocrine and testicular disorders in alloxan-induced diabetic rats. J Coast Life Med 2015;3:809–14.10.12980/jclm.3.2015j5-146Search in Google Scholar

[43] Rastrelli G, Corona G, Maggi M. Testosterone and sexual function in men. Maturitas 2018;112:46–52.10.1016/j.maturitas.2018.04.004Search in Google Scholar

[44] Hemmes RB, Schoch R. High dosage testosterone propionate induces copulatory behavior in the obese male Zucker rat. Physiol Behav 1988;43:321–4.10.1016/0031-9384(88)90195-3Search in Google Scholar

[45] Goswami SK, Inamdar MN, Jamwal R, Dethe S. Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats. J Sex Med 2014;11:1475–83.10.1111/jsm.12535Search in Google Scholar PubMed

[46] Goswami SK, Pandre MK, Jamwal R, Dethe S, Agarwal A, Inamdar MN. Screening for rho-kinase 2 inhibitory potential of Indian medicinal plants used in management of erectile dysfunction. J Ethnopharmacol 2012;144:483–9.10.1016/j.jep.2012.07.045Search in Google Scholar PubMed

[47] Goswami SK, Inamdar MN, Dethe SM, Gururaj GM, Jamwal R, Bhaskar A, et al. Erectogenic and aphrodisiac property of Moringa oleifera: involvement of soluble epoxide hydrolase enzyme. Phytother Res 2016;30:1119–27.10.1002/ptr.5614Search in Google Scholar PubMed

[48] Zheng H, Li L, Sun B, Gao Y, Song W, Zhao X, et al. Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors. Eur J Med Chem 2018;150:30–8.10.1016/j.ejmech.2018.02.039Search in Google Scholar PubMed

[49] Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, et al. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovasc Ther 2017;35. DOI: 10.1111/1755-5922.12259Search in Google Scholar PubMed PubMed Central

[50] Pattanaik S, Kaundal P, Mavuduru RS, Singh SK, Mandal AK. Endothelial dysfunction in patients with erectile dysfunction: a double-blind, randomized-control trial using tadalafil. Sex Med 2019;7:41–7.10.1016/j.esxm.2018.11.008Search in Google Scholar PubMed PubMed Central

[51] Goswami SK, Vishwanath M, Gangadarappa SK, Razdan R, Inamdar MN. Efficacy of ellagic acid and sildenafil in diabetes-induced sexual dysfunction. Pharmacogn Mag 2014;10:S581–7.10.4103/0973-1296.139790Search in Google Scholar PubMed PubMed Central

[52] Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira FC, et al. Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker. Cardiovasc Diabetol 2013;12:44.10.1186/1475-2840-12-44Search in Google Scholar PubMed PubMed Central

Received: 2018-09-12
Accepted: 2019-04-18
Published Online: 2019-07-17

© 2019 Walter de Gruyter GmbH, Berlin/Boston

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  2. Glial pathology in neuropsychiatric disorders: a brief review
  3. Original Articles
  4. Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats
  5. The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
  6. Evaluation of the antianxiety and antidepressant activities of mosapride in Wistar albino rats
  7. Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats
  8. Evaluating exercise challenge to validate cardiac autonomic dysfunction in lean PCOS phenotype
  9. Involvement of proinflammatory cytokines and metallothionein in the repairing of arsenic-mediated uterine tissue damage by curcumin
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https://doi.org/10.1515/jbcpp-2018-0222
Keywords for this article
Bridelia ferruginea; Dracaena arborea; Mondia whitei; prediabetic rats; sexual behavior

Articles in the same Issue

  1. Minireview
  2. Glial pathology in neuropsychiatric disorders: a brief review
  3. Original Articles
  4. Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats
  5. The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
  6. Evaluation of the antianxiety and antidepressant activities of mosapride in Wistar albino rats
  7. Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats
  8. Evaluating exercise challenge to validate cardiac autonomic dysfunction in lean PCOS phenotype
  9. Involvement of proinflammatory cytokines and metallothionein in the repairing of arsenic-mediated uterine tissue damage by curcumin
  10. Antioxidant potentials and effects on the hematology and osmotic fragility scores of a polyherbal formulation used in Southeast Nigeria
  11. Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model
  12. Phytochemicals and antidiabetic activity of the aqueous extract of the Punica granatum fruit in streptozotocin-induced diabetic mice
  13. Ficus cunia Buch.-Ham. ex Roxb. (leaves): An experimental evaluation of the cytotoxicity, thrombolytic, analgesic and neuropharmacological activities of its methanol extract
  14. Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling
  15. Case Report
  16. A rare case of clomiphene-induced leukocytoclastic vasculitis
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