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Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling

  • Olufunke Eunice Ola-Davies , Ademola Adetokunbo Oyagbemi EMAIL logo , Temidayo Olutayo Omobowale , Israel Akande and Anofi Ashafa
Published/Copyright: May 3, 2019
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 30 Issue 4

Abstract

Background

Recently, the incidences of hypertension and environmental pollution have increased significantly. This study investigates the antihypertensive effect of Annona muricata extract against K2Cr2O7-induced hypertension.

Methods

Fifty rats were used for this study, which were divided into five groups of 10 rats each. Rats in Group A received normal saline, and those in Groups B, C, D, and E were treated with A. muricata extract alone at 250 mg/kg, K2Cr2O7 at 30 mg/kg, pretreated with the extract at 250 mg/kg, and pretreated with gallic acid at 60 mg/kg for 14 days, respectively, and thereafter administered with a single intraperitoneal injection of K2Cr2O7 at 30 mg/kg.

Results

Administration of K2Cr2O7 significantly increased systolic, diastolic, and mean arterial pressure and caused prolonged QT and QTc intervals. Further, pretreatment with the extract at 250 mg/kg and gallic acid at 60 mg/kg significantly reduced high blood pressure to near-normal values. K2Cr2O7 intoxication led to significant increases in serum advanced oxidative protein products, myeloperoxidase, and xanthine oxidase, while serum nitric oxide (NO) also reduced significantly. Immunohistochemistry of the renal kidney injury molecule (Kim-1) and p38 MAPK showed increased expressions following the administration of K2Cr2O7 together with the downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Pretreatment with the extract at 250 mg/kg and gallic acid at 60 mg/kg also increased the expressions of Nrf2 and downregulated Kim-1 and p38.

Conclusion

Together, we found that pretreatment with the extract at 250 mg/kg and gallic acid at 60 mg/kg normalized the blood pressure, reduced the markers of oxidative stress, and improved the antioxidant defense system and serum NO bioavailability.

Keywords: Annona muricata; antihypertensive; antioxidant; hypertension; potassium dichromate

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-06-23
Accepted: 2019-02-06
Published Online: 2019-05-03

© 2019 Walter de Gruyter GmbH, Berlin/Boston

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  8. Evaluating exercise challenge to validate cardiac autonomic dysfunction in lean PCOS phenotype
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  13. Ficus cunia Buch.-Ham. ex Roxb. (leaves): An experimental evaluation of the cytotoxicity, thrombolytic, analgesic and neuropharmacological activities of its methanol extract
  14. Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling
  15. Case Report
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https://doi.org/10.1515/jbcpp-2018-0172
Keywords for this article
Annona muricata; antihypertensive; antioxidant; hypertension; potassium dichromate

Articles in the same Issue

  1. Minireview
  2. Glial pathology in neuropsychiatric disorders: a brief review
  3. Original Articles
  4. Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats
  5. The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
  6. Evaluation of the antianxiety and antidepressant activities of mosapride in Wistar albino rats
  7. Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats
  8. Evaluating exercise challenge to validate cardiac autonomic dysfunction in lean PCOS phenotype
  9. Involvement of proinflammatory cytokines and metallothionein in the repairing of arsenic-mediated uterine tissue damage by curcumin
  10. Antioxidant potentials and effects on the hematology and osmotic fragility scores of a polyherbal formulation used in Southeast Nigeria
  11. Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model
  12. Phytochemicals and antidiabetic activity of the aqueous extract of the Punica granatum fruit in streptozotocin-induced diabetic mice
  13. Ficus cunia Buch.-Ham. ex Roxb. (leaves): An experimental evaluation of the cytotoxicity, thrombolytic, analgesic and neuropharmacological activities of its methanol extract
  14. Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling
  15. Case Report
  16. A rare case of clomiphene-induced leukocytoclastic vasculitis
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