A rare case of clomiphene-induced leukocytoclastic vasculitis
-
Yashika Garg
,
Sourabh Jain
Abstract
Clomiphene citrate is a first-line drug for the induction of ovulation in infertility cases. Leukocytoclastic vasculitis (LCV) is an extremely rare serious adverse drug reaction to clomiphene. We report here the case of a 30-year-old Indian female patient who presented with generalized petechiae and palpable purpura without fever and sparing the mucosa, temporally related to clomiphene intake and consistent with LCV histologically. Clomiphene was stopped and the patient was treated symptomatically with prednisolone 40 mg/day, oral levocetirizine 5 mg twice daily, and emollients and calamine lotion topically. The patient improved over 3–4 weeks. The prednisolone dose was tapered weekly and withdrawn gradually. To date, drug-induced LCV has not been previously reported with clomiphene. Although rare, clomiphene could be considered a potential cause of drug-induced cutaneous LCV in the differential diagnosis of erythematosus rash with non-blanching petechiae and purpura.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: Authors state no potential conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The research related to human use has complied with all the relevant national regulations and institutional policies, was performed in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board (Vardhman Mahavir Medical College and Safdarjung Hospital, Department of Dermatology, & Department of Pharmacology, New Delhi, India) or equivalent committee (ECR/593/Inst/DL/2014).
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Articles in the same Issue
- Minireview
- Glial pathology in neuropsychiatric disorders: a brief review
- Original Articles
- Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats
- The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
- Evaluation of the antianxiety and antidepressant activities of mosapride in Wistar albino rats
- Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats
- Evaluating exercise challenge to validate cardiac autonomic dysfunction in lean PCOS phenotype
- Involvement of proinflammatory cytokines and metallothionein in the repairing of arsenic-mediated uterine tissue damage by curcumin
- Antioxidant potentials and effects on the hematology and osmotic fragility scores of a polyherbal formulation used in Southeast Nigeria
- Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model
- Phytochemicals and antidiabetic activity of the aqueous extract of the Punica granatum fruit in streptozotocin-induced diabetic mice
- Ficus cunia Buch.-Ham. ex Roxb. (leaves): An experimental evaluation of the cytotoxicity, thrombolytic, analgesic and neuropharmacological activities of its methanol extract
- Ameliorative effects of Annona muricata Linn. (Annonaceae) against potassium dichromate-induced hypertension in vivo: involvement of Kim-1/p38 MAPK/Nrf2 signaling
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- A rare case of clomiphene-induced leukocytoclastic vasculitis
