Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
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Stephanie Abiola Tijani
Abstract
Background
Oxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract of Chasmanthera dependens to protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats.
Methods
The C. dependens stems were chopped into pieces, air-dried, and pulverized into powder. One kilogram of the powder was macerated in 1 L of methanol for 72 h. The mixture was filtered and evaporated using rotatory evaporator to obtain the extract of C. dependens. Adult male rats were divided into eight groups of six animals per group and were pretreated orally with the methanol extract of C. dependens (200, 400, and 800 mg/kg) or cimetidine (CIM), a standard drug (50 mg/kg), for 7 days. Gastric ulcer was induced orally with indomethacin. Ulcerogenic parameters, oxidative stress indices, and histopathological examination of the stomach were assessed to monitor the gastroprotective potential of C. dependens stem.
Results
Indomethacin caused severe gastric mucosa damage and significant reduction in the gastric mucosa antioxidant system with concomitant increase in the level of lipid peroxidation. Pretreatment with the methanol extract of C. dependens or CIM significantly reduced the formation of ulcer at the different doses administered. Similarly, pretreatments with the extract or CIM improved the antioxidant system, decreased acid output, lipid peroxidation, and improved the architecture of the gastric mucosa in ulcerated rats.
Conclusions
The results show the gastroprotective effect of the methanolic extract of C. dependens, which may be attributed to its antioxidant properties.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium
- Metabolism
- Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria
- Infection
- The effects of oral pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
- Cardiovascular Function
- Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent
- Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis
- Phytotherapy
- Role of reactive oxygen species–total antioxidant capacity status in Telfairia occidentalis leaves–associated spermatoprotective effect: a pointer to fatty acids benefit
- Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
- Oxidative Stress
- Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
- Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
- Hematological Profile
- Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
- Hematology and erythrocyte osmotic fragility of the Franquet’s fruit bat (Epomops franqueti)
- Behavior and Neuroprotection
- Haloperidol-induced parkinsonism is attenuated by varenicline in mice
- Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice
- Effects of acetone extract of Cola nitida on brain sodium-potassium adenosine triphosphatase activity and spatial memory in healthy and streptozotocin-induced diabetic female Wistar rats
- Case Report
- Conservative treatment of postoperative chylothorax: a case report
- Short Communication
- Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice
Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium
- Metabolism
- Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria
- Infection
- The effects of oral pregabalin on post-Lichtenstein herniorrhaphic pain: a randomized clinical trial
- Cardiovascular Function
- Influence of age and gender on blood pressure variability and baroreflex sensitivity in a healthy population in the Indian sub-continent
- Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis
- Phytotherapy
- Role of reactive oxygen species–total antioxidant capacity status in Telfairia occidentalis leaves–associated spermatoprotective effect: a pointer to fatty acids benefit
- Antidiabetic and renoprotective effect of Anogeissus acuminata leaf extract on experimentally induced diabetic nephropathy
- Oxidative Stress
- Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
- Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats
- Hematological Profile
- Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study
- Hematology and erythrocyte osmotic fragility of the Franquet’s fruit bat (Epomops franqueti)
- Behavior and Neuroprotection
- Haloperidol-induced parkinsonism is attenuated by varenicline in mice
- Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice
- Effects of acetone extract of Cola nitida on brain sodium-potassium adenosine triphosphatase activity and spatial memory in healthy and streptozotocin-induced diabetic female Wistar rats
- Case Report
- Conservative treatment of postoperative chylothorax: a case report
- Short Communication
- Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice
