Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark
-
Godwin C. Akuodor
,
Ndubuisi N. Nwobodo
Abstract
Background:
The Icacina senegalensis root bark is traditionally used for the treatment of gastrointestinal disorders in Nigeria. To date, no scientific study has substantiated or refuted this claim.
Methods:
The antidiarrheal and antimicrobial activities of the ethanol root bark extract were investigated in rats and against some selected diarrhea-causing microorganisms.
Results:
The extract significantly decreased the frequency of castor oil-induced diarrhea, and inhibited the masses and volumes of intestinal fluid accumulation in the castor oil-induced enteropooling method. The distance travelled by the charcoal meal was also decreased by the extract gastrointestinal transit method. The extract also strongly inhibited the growth of some selected microorganisms.
Conclusions:
The ethanol extract of the I. senegalensis root bark showed antidiarrheal activity, thus justifying its long folkloric use in diarrhea treatment. The extract also demonstrated antimicrobial activity against selected diarrheal causing organisms.
Acknowledgments
The authors acknowledge the support of TETFUND in funding the study. The authors also wish to thank Mr. Simon Eze Nwibo and Mr. Chibueze Nwonu for their technical assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved its submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Minireview
- Acorus calamus: a bio-reserve of medicinal values
- Behavior and Neuroprotection
- Electrodermal response to auditory stimuli in relation to menopausal transition period
- Reproduction
- First-line antituberculosis drugs disrupt endocrine balance and induce ovarian and uterine oxidative stress in rats
- Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water
- Cardiovascular Function
- Ameliorative effect of Azadirachta indica on sodium fluoride-induced hypertension through improvement of antioxidant defence system and upregulation of extracellular signal regulated kinase 1/2 signaling
- Regulation of hypoxia inducible factor/prolyl hydroxylase binding domain proteins 1 by PPARα and high salt diet
- Oxidative Stress
- Amla (Emblica officinalis) improves hepatic and renal oxidative stress and the inflammatory response in hypothyroid female wistar rats fed with a high-fat diet
- Metabolism
- Cocos nucifera water improves metabolic functions in offspring of high fat diet fed Wistar rats
- Prevalence of dry eye disease and its association with dyslipidemia
- Phytotherapy
- An isobolographic analysis of the anti-nociceptive effect of geraniin in combination with morphine or diclofenac
- Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark
- Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O’Rorke) Baill bark
- Corrigendum
- Corrigendum to: Possible modulation of PPAR-γ cascade against depression caused by neuropathic pain in rats
Artikel in diesem Heft
- Frontmatter
- Minireview
- Acorus calamus: a bio-reserve of medicinal values
- Behavior and Neuroprotection
- Electrodermal response to auditory stimuli in relation to menopausal transition period
- Reproduction
- First-line antituberculosis drugs disrupt endocrine balance and induce ovarian and uterine oxidative stress in rats
- Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water
- Cardiovascular Function
- Ameliorative effect of Azadirachta indica on sodium fluoride-induced hypertension through improvement of antioxidant defence system and upregulation of extracellular signal regulated kinase 1/2 signaling
- Regulation of hypoxia inducible factor/prolyl hydroxylase binding domain proteins 1 by PPARα and high salt diet
- Oxidative Stress
- Amla (Emblica officinalis) improves hepatic and renal oxidative stress and the inflammatory response in hypothyroid female wistar rats fed with a high-fat diet
- Metabolism
- Cocos nucifera water improves metabolic functions in offspring of high fat diet fed Wistar rats
- Prevalence of dry eye disease and its association with dyslipidemia
- Phytotherapy
- An isobolographic analysis of the anti-nociceptive effect of geraniin in combination with morphine or diclofenac
- Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark
- Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O’Rorke) Baill bark
- Corrigendum
- Corrigendum to: Possible modulation of PPAR-γ cascade against depression caused by neuropathic pain in rats
