Indexes of the erythropoietin level in the blood plasma of chronic heart failure patients with anemia
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Kamala Kh. Zahidova
Abstract
Background:
Anemia aggravates the disease course and the survival rate of chronic heart failure (CHF) patients. The purpose of the study was to investigate the level of erythropoietin (EPO) in CHF patients with anemic syndrome, with the aim to more accurately assess the severity of the disease and its treatment, depending on the anemia degree.
Methods:
Patients with ischemic CHF of I–IV functional class (FC) with and without anemia were examined (total number of patients=208, patients with anemia=174). The EPO was determined using the enzyme-linked immunosorbent assay. Before treatment, the patients underwent the following medical therapy: angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, long-acting nitrates, diuretics, digoxin, and beta-blockers at individual doses. Depending on the plasma EPO level, the CHF patients with anemia were divided into four randomized groups in terms of treatment.
Results:
Normal erythropoietinemia was found in 36.2% of the CHF patients with anemic syndrome (I–III FC), hypoerythropoietinemia in 44.8% (III–IV FC), and hypererythropoietinemia in 18.96% (III–V FC). The EPO level in the blood plasma of the patients with I–II FC CHF with hypoerythropoietinemia, who were treated with methoxy polyethylene glycol-epoetin β (MEB), increased by 2.2 times. Combination therapy with disease-modifying drugs and MEB led to a significant increase in the plasma EPO level in the CHF patients with hypoerythropoietinemia.
Conclusions:
It was shown that the EPO level in patients with CHF and anemia did not always drop. Hypererythropoietinemia in patients with CHF and anemia leads to an unfavorable treatment prediction. This necessitates the investigation of the EPO level in all patients with CHF before and after treatment, with the aim of correcting the anemic syndrome. The research showed that the combined therapy of patients with CHF and anemia using MEB medication and iron with regard to the EPO level in the blood plasma improved their overall physical condition, reduced heart failure symptoms and hospitalization frequency, and demonstrated a clear tendency to reduce the general mortality rate.
Acknowledgments
The author thanks Afet Mamedli for help in conducting the study.
Author contributions: The author has accepted responsibility for the entire content of this submitted manuscript and approved the submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of the data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Behavior and Neuroprotection
- Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model
- Cardiovascular Function
- Indexes of the erythropoietin level in the blood plasma of chronic heart failure patients with anemia
- Oxidative Stress
- Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats
- Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat
- Metabolism
- Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats
- Effect of L-carnitine on diabetes-induced changes of skeletal muscles in rats
- Inflammation
- Swimming, but not vitamin E, ameliorates prothrombotic state and hypofibrinolysis in a rat model of nonalcoholic fatty liver disease
- Infection
- In vitro ovicidal activity of poly lactic acid curcumin-nisin co-entrapped nanoparticle against Fasciola spp. eggs and its reproductive toxicity
- Phytotherapy
- Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl
- Anti-invasive and antiproliferative effects of Pleurotus ostreatus extract on acute leukemia cell lines
- Letter to the Editor
- Is antiarrhythmic drug effectiveness stable? Extrapolating ICD in different space weather conditions
- Acknowledgment
Artikel in diesem Heft
- Frontmatter
- Behavior and Neuroprotection
- Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model
- Cardiovascular Function
- Indexes of the erythropoietin level in the blood plasma of chronic heart failure patients with anemia
- Oxidative Stress
- Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats
- Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat
- Metabolism
- Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats
- Effect of L-carnitine on diabetes-induced changes of skeletal muscles in rats
- Inflammation
- Swimming, but not vitamin E, ameliorates prothrombotic state and hypofibrinolysis in a rat model of nonalcoholic fatty liver disease
- Infection
- In vitro ovicidal activity of poly lactic acid curcumin-nisin co-entrapped nanoparticle against Fasciola spp. eggs and its reproductive toxicity
- Phytotherapy
- Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl
- Anti-invasive and antiproliferative effects of Pleurotus ostreatus extract on acute leukemia cell lines
- Letter to the Editor
- Is antiarrhythmic drug effectiveness stable? Extrapolating ICD in different space weather conditions
- Acknowledgment
