Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats
-
Temiday O. Omóbòwálé
,
Ayorinde M. Folasire
Abstract
Background:
The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats.
Methods:
Sixty male rats (Wistar strain) were used in this study. They were divided into six groups (A–F) each containing 10 animals. Group A was the control. Rats in Groups B, C, and D were treated with DOX at the dosage of 15 mg/kg body weight i.p. Prior to this treatment, rats in Groups C and D had been treated orally with GA for 7 days at the dosage of 60 and 120 mg/kg, respectively. Animals from Groups E and F received only 60 and 120 mg/kg GA, respectively, which were administered orally for 7 days.
Results:
The exposure of rats to DOX led to a significant (p<0.05) decrease in the cardiac antioxidant defence system and elevation of creatine kinase myocardial band and lactate dehydrogenase. The electrocardiography results showed a significant decrease in heart rate, QRS, and QT-segment prolongation. GA alone improved the antioxidant defence system.
Conclusions:
The GA pretreatment significantly alleviated GA-associated ECG abnormalities, restored the antioxidant status and prevented cardiac damage.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organisation(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Behavior and Neuroprotection
- Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model
- Cardiovascular Function
- Indexes of the erythropoietin level in the blood plasma of chronic heart failure patients with anemia
- Oxidative Stress
- Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats
- Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat
- Metabolism
- Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats
- Effect of L-carnitine on diabetes-induced changes of skeletal muscles in rats
- Inflammation
- Swimming, but not vitamin E, ameliorates prothrombotic state and hypofibrinolysis in a rat model of nonalcoholic fatty liver disease
- Infection
- In vitro ovicidal activity of poly lactic acid curcumin-nisin co-entrapped nanoparticle against Fasciola spp. eggs and its reproductive toxicity
- Phytotherapy
- Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl
- Anti-invasive and antiproliferative effects of Pleurotus ostreatus extract on acute leukemia cell lines
- Letter to the Editor
- Is antiarrhythmic drug effectiveness stable? Extrapolating ICD in different space weather conditions
- Acknowledgment
Articles in the same Issue
- Frontmatter
- Behavior and Neuroprotection
- Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model
- Cardiovascular Function
- Indexes of the erythropoietin level in the blood plasma of chronic heart failure patients with anemia
- Oxidative Stress
- Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats
- Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat
- Metabolism
- Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats
- Effect of L-carnitine on diabetes-induced changes of skeletal muscles in rats
- Inflammation
- Swimming, but not vitamin E, ameliorates prothrombotic state and hypofibrinolysis in a rat model of nonalcoholic fatty liver disease
- Infection
- In vitro ovicidal activity of poly lactic acid curcumin-nisin co-entrapped nanoparticle against Fasciola spp. eggs and its reproductive toxicity
- Phytotherapy
- Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl
- Anti-invasive and antiproliferative effects of Pleurotus ostreatus extract on acute leukemia cell lines
- Letter to the Editor
- Is antiarrhythmic drug effectiveness stable? Extrapolating ICD in different space weather conditions
- Acknowledgment
