Prevalence, risk factors and antimicrobial susceptibility pattern of extended spectrum β-lactamase-producing bacteria in a tertiary care hospital
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Dilip Chandrasekhar
,
Jaffer Chalilparambil
Abstract
Background: The widespread misuse of antibiotics over the past several decades has been regarded as the contributing factor in the development of resistance toward them. Extended spectrum β-lactamases (ESBLs) are enzymes produced by certain bacteria that can make them resistant to certain antibiotics. Early detection of ESBL strains and judicious use of antibiotics and proper implementation of infection control strategies are essential to prevent the spread of this threat in the community. The study aimed at appraising the prevalence, risk factors and antimicrobial susceptibility pattern of ESBL-producing microorganisms.
Methods: A prospective observational study was carried out in a tertiary care referral hospital located in Malappuram district of Kerala among inpatients with infection by ESBL-producing bacteria in order to estimate the prevalence, risk factors and their antibiotic susceptibility pattern.
Results: Out of the total 1156 patients studied, 118 had confirmed diagnosis on the presence of ESBL-producing microorganisms. Overall, 9.79% of all samples growing Enterobacteriaceae yielded an ESBL producer. Out of the total isolates identified, 66.1% were urinary tract infections, 15.1% were respiratory tract infections, 14.4% were surgical site infections and the remaining constituted blood stream infections. The highest antimicrobial activity against ESBL-producing isolates was observed for meropenem.
Conclusions: High prevalence of ESBL-producing organisms is evident in the study setting implicating the necessity to report the ESBL production along with the routine sensitivity reports supplemented with control measures which can assist a clinician in prescribing appropriate antibiotics.
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©2016 by De Gruyter
Articles in the same Issue
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- Infection
- Prevalence, risk factors and antimicrobial susceptibility pattern of extended spectrum β-lactamase-producing bacteria in a tertiary care hospital
- Phytotherapy
- Phytochemical, sub-acute toxicity, and antibacterial evaluation of Cordia sebestena leaf extracts
- Short Communication
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Articles in the same Issue
- Frontmatter
- Review
- Ulinastatin – a newer potential therapeutic option for multiple organ dysfunction syndrome
- Behavior and Neuroprotection
- Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain
- Anti-nociceptive activity of a few structurally related trimethoxy flavones and possible mechanisms involved
- Oxidative Stress
- A mechanism-based pharmacological evaluation of efficacy of Flacourtia indica in management of dyslipidemia and oxidative stress in hyperlipidemic rats
- Aqueous extracts of avocado pear (Persea americana Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro
- Biochemical effects of lead exposure on oxidative stress and antioxidant status of battery manufacturing workers of Western Maharashtra, India
- Hematological Profile
- Phenotypic variations in osmotic lysis of Sahel goat erythrocytes in non-ionic glucose media
- Infection
- Prevalence, risk factors and antimicrobial susceptibility pattern of extended spectrum β-lactamase-producing bacteria in a tertiary care hospital
- Phytotherapy
- Phytochemical, sub-acute toxicity, and antibacterial evaluation of Cordia sebestena leaf extracts
- Short Communication
- Leaching from the stratum corneum does not explain the previously reported elevated potassium ion concentration in sweat
