A prospective drug use evaluation of antihypertensive drugs in in-patients of a tertiary referral care hospital
-
Ajmal Mankadavath
,
Tina Thomas
Abstract
Background: Hypertension is a chronic illness associated with high morbidity and mortality. Once hypertension is diagnosed, starting antihypertensive therapy on a long-term basis along with regular follow up is important. Standardizing treatment guidelines and conducting drug utilization studies at regular intervals help physicians to prescribe drugs rationally. The present study was conducted to analyze the prescription patterns of antihypertensive drugs in a tertiary care referral hospital in Malabar region, Kerala, India.
Methods: The study was conducted at the General Medicine and Cardiology Department involving the in-patients. Patients suffering from essential hypertension with or without other co-morbidities were included in the study. The frequency and proportion of prescribing different groups of antihypertensive drugs as monotherapy or combination therapy, and prescription of fixed drug combinations (FDCs) were analyzed. A total of 200 hypertensive patients were included in the study. Patient data were collected from in-patient’s case sheets and direct interviews with the patients and their observers.
Results: The majority of the patients were females with 56%, whereas the males comprised 44%, with most of the patients suffering from stage-II hypertension. The study revealed that a high proportion of the hypertensive patients had co-morbid diabetes mellitus. The most commonly prescribed class of antihypertensive drugs was angiotensin receptor blockers, followed by calcium channel blockers and β-blockers. With regard to patient therapy, 32.0% received monotherapy, whereas 68.0% received combination therapy, 16% of which received FDCs.
Conclusions: The study shows that clinical pharmacists can play a key role in promoting rational prescription and improving adherence to medication.
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©2015 by De Gruyter
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Articles in the same Issue
- Frontmatter
- Genotoxicity and Cytotoxicity
- Randomized, double-blind, placebo-controlled study to investigate the pharmacodynamic interaction of 5-HT3 antagonist ondansetron and paracetamol in postoperative patients operated in an ENT department under local anesthesia
- Influence of vitamin E and quercetin on Nigerian Bonny Light crude oil-induced neuronal and testicular toxicity in Wistar rats
- Vascular Conditions
- Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats
- Oxidative Stress
- Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat
- Modulatory effects of cod liver oil on the antioxidant status and oxidative stress induced by acute exposure to carbon tetrachloride (CCL4) in experimental animal models
- Hematological Profile
- Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats
- Inflammation
- Physiological characteristics of crab Portunus sanguinolentus egg mass extract from southeast coast of India
- Phytotherapy
- Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type
- Erythrina lysistemon-derived flavonoids account only in part for the plant’s specific effects on rat uterus and vagina
- A prospective drug use evaluation of antihypertensive drugs in in-patients of a tertiary referral care hospital
- Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from Adenia cissampeloides
- Short Communication
- Anti-inflammatory effects of aqueous extract of Mangifera indica in Wistar rats
