Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats
-
Ryszard Stefan Gomolka
,
Katarzyna Czarzasta
Abstract
Background: Numerous studies suggest that apelin plays a significant role in cardiovascular regulation and in the pathogenesis of hypertension. The purpose of the present study was to determine whether apelin-13 (AP-13) is involved in the regulation of cardiovascular responses to acute stress in spontaneous hypertension.
Methods: The effects of intracerebroventricular (ICV) administration of AP-13 on changes in mean arterial blood pressure (MABP) and heart rate evoked by an alarming stress (air jet stress) were compared in awake normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). The rats were divided into four groups: Groups 1 (WKY) and 3 (SHR) received ICV infusion of 0.9% sodium chloride (vehicle), whereas Groups 2 (WKY) and 4 (SHR) were ICV infused with AP-13. All animals were exposed to the alarming stress.
Results: During the ICV administration of the vehicle, the pressor response to stress was significantly greater in SHR than in WKY. The ICV infusion of AP-13 reduced the pressor response evoked by the application of the stressor in SHR but not in WKY. It also abolished the difference in stress-induced MABP increases between WKY and SHR.
Conclusions: The results show that centrally acting apelin may play an essential role in the regulation of blood pressure responses to an alarming stress in SHR rats.
Acknowledgments
The authors are indebted to Mrs. MarzannaTkaczyk and Mr. Marcin Kumosa for their skillful technical assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The study was supported by the grant 1MAW2/2011-2012. The project was carried out with the use of CePT infrastructure financed by the European Union – the European Regional Development Fund within the “Operational Programme Innovative Economy for 2007–2013”.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Articles in the same Issue
- Frontmatter
- Genotoxicity and Cytotoxicity
- Randomized, double-blind, placebo-controlled study to investigate the pharmacodynamic interaction of 5-HT3 antagonist ondansetron and paracetamol in postoperative patients operated in an ENT department under local anesthesia
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- Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats
- Oxidative Stress
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- Modulatory effects of cod liver oil on the antioxidant status and oxidative stress induced by acute exposure to carbon tetrachloride (CCL4) in experimental animal models
- Hematological Profile
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- Inflammation
- Physiological characteristics of crab Portunus sanguinolentus egg mass extract from southeast coast of India
- Phytotherapy
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- Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from Adenia cissampeloides
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