Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats
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Taofeek O. Usman
,
Lawrence A. Olatunji
Abstract
Background: Studies have shown that the hyperglycemic state induced by intravenous glucagon or glucose infusion may lead to inhibition of gastric acid secretion through the inhibition of gastric vagus activity. Histamine is a well-known mammalian acid secretagogue and it stimulates acid secretion through H2 receptors. Therefore, the aim of this study was to determine what effect an acute hyperglycemic or hypoglycemic state would have on histamine-stimulated acid secretion.
Methods: Male Wistar rats weighing between 200 and 250 g were divided into three groups that received an intravenous infusion of normal saline (control group), glucose (hyperglycemic group), or insulin (hypoglycemic group) followed by injection of histamine to stimulate acid secretion. The oesophageal and duodenal ends of the rats’ stomach were cannulated with polythene tubing and the stomach was perfused at room temperature using a Langendoff perfusion apparatus. The effluent was collected in aliquots over 10 min per sample and its pH was measured.
Results: There was a significant (p<0.05) decrease in acid secretion following histamine injection in the hyperglycemic rats, while histamine injection led to an increase (p<0.05) in acid secretion in the hypoglycemic rats.
Conclusions: These results show that hyperglycemic state would result in attenuated histamine-stimulated gastric acid secretion, while hypoglycemic state would lead to increased histamine-stimulated gastric acid secretion.
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Articles in the same Issue
- Frontmatter
- Genotoxicity and Cytotoxicity
- Randomized, double-blind, placebo-controlled study to investigate the pharmacodynamic interaction of 5-HT3 antagonist ondansetron and paracetamol in postoperative patients operated in an ENT department under local anesthesia
- Influence of vitamin E and quercetin on Nigerian Bonny Light crude oil-induced neuronal and testicular toxicity in Wistar rats
- Vascular Conditions
- Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats
- Oxidative Stress
- Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat
- Modulatory effects of cod liver oil on the antioxidant status and oxidative stress induced by acute exposure to carbon tetrachloride (CCL4) in experimental animal models
- Hematological Profile
- Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats
- Inflammation
- Physiological characteristics of crab Portunus sanguinolentus egg mass extract from southeast coast of India
- Phytotherapy
- Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type
- Erythrina lysistemon-derived flavonoids account only in part for the plant’s specific effects on rat uterus and vagina
- A prospective drug use evaluation of antihypertensive drugs in in-patients of a tertiary referral care hospital
- Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from Adenia cissampeloides
- Short Communication
- Anti-inflammatory effects of aqueous extract of Mangifera indica in Wistar rats
